Nicholas Sheets
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View article: Disparities in Trauma Care for Latino Patients: An Analysis by Trauma Center Verification Level
Disparities in Trauma Care for Latino Patients: An Analysis by Trauma Center Verification Level Open
Introduction Trauma is the leading cause of death for individuals under 45 in the United States (US), with significant disparities in outcomes among minority groups. Latinos, the largest ethnic minority in the US, often face barriers to op…
View article: Severe Cutaneous Reaction Induced by Clindamycin: A Case Report of Toxic Epidermal Necrolysis
Severe Cutaneous Reaction Induced by Clindamycin: A Case Report of Toxic Epidermal Necrolysis Open
Toxic epidermal necrolysis (TEN) is a rare, acute inflammatory skin reaction that results in skin blistering and extensive epidermal detachment. Stevens-Johnson syndrome (SJS) and TEN are unified aspects on a spectrum varying in the severi…
View article: Orbital Trauma Epidemiologic Characteristics by Life Stage
Orbital Trauma Epidemiologic Characteristics by Life Stage Open
Study Design Retrospective database review. Objective This study aims to characterize and compare the epidemiological factors of orbital trauma between life stages by utilizing the National Electronic Injury Surveillance System (NEISS), a …
View article: Impact of Trauma Verification Level on Management and Outcomes of Combined Traumatic Brain and Solid Organ Injuries: An NTDB Retrospective Review
Impact of Trauma Verification Level on Management and Outcomes of Combined Traumatic Brain and Solid Organ Injuries: An NTDB Retrospective Review Open
Background Level-I and level-II trauma centers are required to offer equivalent resources since “The Orange Book.” This study evaluates differences between level-I and level-II management of solid organ injury (SOI) with traumatic brain in…
View article: The epidemiology of firework-related injuries in the US, 2012–2022
The epidemiology of firework-related injuries in the US, 2012–2022 Open
Background This study aimed to examine the epidemiology of firework-related injuries within a national population between 2012 and 2022, including the severity of injury by year, patient demographics, body region injured, firework type, an…
View article: Unintentional Drownings in Pediatric Populations: Injury Prevention in the Post-COVID-19 Era
Unintentional Drownings in Pediatric Populations: Injury Prevention in the Post-COVID-19 Era Open
Unintentional injuries are one of the leading causes of death in Americans. A large proportion of these deaths are attributable to accidental drownings and falls, both of which oftentimes take place in or around swimming pools and swimming…
View article: Children ages one to four are disproportionally affected by chemical burns in a cross-sectional analysis of NEISS 2012–2021
Children ages one to four are disproportionally affected by chemical burns in a cross-sectional analysis of NEISS 2012–2021 Open
Children ages four and under are disproportionately affected by chemical burns due to non-intentional exposure of HC&PCPs, with laundry detergents and bleaches being the most common causative agents. Adequate storage of all HC&PCPs and imp…
View article: Low Prevalence but High Impact of COVID-19 Positive Status in Adult Trauma Patients: A Multi-institutional Analysis of 28 904 Patients
Low Prevalence but High Impact of COVID-19 Positive Status in Adult Trauma Patients: A Multi-institutional Analysis of 28 904 Patients Open
Background Few large investigations have addressed the prevalence of COVID-19 infection among trauma patients and impact on providers. The purpose of this study was to quantify the prevalence of COVID-19 infection among trauma patients by …
View article: Bradyarrhythmia After Remdesivir Administration in SARS-CoV-2: A Review of Literature and Meta-Analysis of Observational Studies in Epidemiology
Bradyarrhythmia After Remdesivir Administration in SARS-CoV-2: A Review of Literature and Meta-Analysis of Observational Studies in Epidemiology Open
Data from real-world observational studies suggest that treating COVID-19 patients with RDV may predispose the development of bradyarrhythmia. The importance of this observation is of uncertain clinical significance as some observational s…
View article: Corrected QT Interval Prolongation, Elevated Troponin, and Mortality in Hospitalized COVID-19 Patients
Corrected QT Interval Prolongation, Elevated Troponin, and Mortality in Hospitalized COVID-19 Patients Open
Growing concern for cardiovascular sequelae of coronavirus disease 2019 (COVID-19) has prompted many researchers to investigate the role of cardiovascular complications in mortality due to SARS-CoV-2. Obtaining a simple electrocardiogram f…
View article: Impact of the COVID-19 Pandemic on Trauma Encounters
Impact of the COVID-19 Pandemic on Trauma Encounters Open
Objectives The Coronavirus Disease 2019 pandemic has affected the health care system significantly. We compare 2019 to 2020 to evaluate how trauma encounters has changed during the pandemic. Methods Retrospective analysis using a large US …
View article: A Re-Evaluation of the Effect of Trauma Center Verification Level on the Early Risk of Death in Hemodynamically Unstable Patients
A Re-Evaluation of the Effect of Trauma Center Verification Level on the Early Risk of Death in Hemodynamically Unstable Patients Open
Background Studies show increased early and overall mortality at level II compared to level I trauma centers in hemodynamically unstable patients. We hypothesize there is no mortality difference between level I and level II centers applyin…
View article: The Effect of Trauma Center Verification Level on Outcomes in Traumatic Brain Injury Patients Undergoing Interfacility Transfer
The Effect of Trauma Center Verification Level on Outcomes in Traumatic Brain Injury Patients Undergoing Interfacility Transfer Open
Background Previous literature demonstrates increased mortality for traumatic brain injury (TBI) with transfer to a Level II versus Level I trauma center. Our objective was to determine the effect of the most recent American College of Sur…
View article: Facing Double Jeopardy: The Transition Experiences of Latina Family Caregivers of Young Adults With Disabilities Living in a Rural Community
Facing Double Jeopardy: The Transition Experiences of Latina Family Caregivers of Young Adults With Disabilities Living in a Rural Community Open
The transition for young adults with disabilities from high school to gainful employment is often difficult. This transition is even harder for students from minority or marginalized backgrounds, including young adults who identify as Lati…
View article: Author Correction: Blocking Zika virus vertical transmission
Author Correction: Blocking Zika virus vertical transmission Open
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
View article: Blocking Zika virus vertical transmission
Blocking Zika virus vertical transmission Open
The outbreak of the Zika virus (ZIKV) has been associated with increased incidence of congenital malformations. Although recent efforts have focused on vaccine development, treatments for infected individuals are needed urgently. Sofosbuvi…
View article: Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis
Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis Open
One of the major challenges of the current Zika virus (ZIKV) epidemic is to prevent congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant women. Given the urgent need for ZIKV prophylaxis and treatme…
View article: An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses
An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses Open
Interferon-regulatory factors (IRFs) are a family of transcription factors (TFs) that translate viral recognition into antiviral responses, including type I interferon (IFN) production. Dengue virus (DENV) and other clinically important fl…