Nicholas Stone
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View article: Revealing Prostate Calcification Heterogeneity through Their Elemental Distribution
Revealing Prostate Calcification Heterogeneity through Their Elemental Distribution Open
View article: Fluorescence Guided Raman Spectroscopy enables the training of robust support vector machines for the detection of tumour marker proteins
Fluorescence Guided Raman Spectroscopy enables the training of robust support vector machines for the detection of tumour marker proteins Open
Raman spectroscopy provides comprehensive biochemical information on a sample’s composition, yet it is often used to analyze aggregated spectra rather than specific shifts. We introduce Fluorescence Guided Raman Spectroscopy (FGRS) as a me…
View article: Clustered, SERS-Active, Ultrasmall AuNPs for Photothermal Therapy
Clustered, SERS-Active, Ultrasmall AuNPs for Photothermal Therapy Open
The results provide proof-of-concept for the potential of these AuNCs in photothermal cancer therapy. Future work should focus on improving tumour targeting, optimizing treatment parameters, and assessing long-term safety to advance this p…
View article: Prostate microcalcification crystallography as a marker of pathology
Prostate microcalcification crystallography as a marker of pathology Open
View article: An All-in-One Nanoheater and Optical Thermometer Fabricated from Fractal Nanoparticle Assemblies
An All-in-One Nanoheater and Optical Thermometer Fabricated from Fractal Nanoparticle Assemblies Open
We designed and optimized a dual-functional photothermal agent that performs as a nanoheater and real-time optical thermometer by leveraging gold nanoparticle (AuNP) self-assembly and anti-Stokes thermometry. We engineered colloidally stab…
View article: Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges
Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges Open
The year 2024 marks the 50th anniversary of the discovery of surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity …
View article: Anisotropy visualisation from X-ray diffraction of biological apatite in mixed phase calcified tissue samples
Anisotropy visualisation from X-ray diffraction of biological apatite in mixed phase calcified tissue samples Open
X-ray diffraction is widely used to characterise the mineral component of calcified tissue. Broadening of the diffraction peaks yields valuable information on the size of coherently diffracting domains, sometimes loosely described as cryst…
View article: Gold Nanoraspberries for Surface-Enhanced Raman Scattering: Synthesis, Optimization, and Characterization
Gold Nanoraspberries for Surface-Enhanced Raman Scattering: Synthesis, Optimization, and Characterization Open
In this work, we demonstrate the synthesis of gold nanoraspberries (AuNRB) using a HEPES buffer at room temperature. The study aimed to identify and compare the physicochemical conditions of the AuNRB and gold nanospheres (AuNS) of similar…
View article: Prediction of post-treatment recurrence in early-stage breast cancer using deep-learning with mid-infrared chemical histopathological imaging
Prediction of post-treatment recurrence in early-stage breast cancer using deep-learning with mid-infrared chemical histopathological imaging Open
View article: Plasmonic Nanoparticles for Photothermal Therapy: Benchmarking of Photothermal Properties and Modeling of Heating at Depth in Human Tissues
Plasmonic Nanoparticles for Photothermal Therapy: Benchmarking of Photothermal Properties and Modeling of Heating at Depth in Human Tissues Open
Many different types of nanoparticles have been developed for photothermal therapy (PTT), but directly comparing their efficacy as heaters and determining how they will perform when localized at depth in tissue remains complex. To choose t…
View article: Raman spectroscopy of ovarian and peritoneal tissue in the assessment of ovarian cancer
Raman spectroscopy of ovarian and peritoneal tissue in the assessment of ovarian cancer Open
We demonstrate that Raman spectroscopy is a viable tool for ovarian cancer assessment.
View article: The international society for clinical spectroscopy; reflections on the first 10 years
The international society for clinical spectroscopy; reflections on the first 10 years Open
The article provides a perspective overview of the development and current status of the field of biomedical spectroscopy, on the occasion of the tenth anniversary of the foundation of the International Society for Clinical Spectroscopy (C…
View article: The unreasonable effectiveness of the $n Σv$ approximation
The unreasonable effectiveness of the $n Σv$ approximation Open
In kinetic theory, the classic $n Σv$ approach calculates the rate of particle interactions from local quantities: the number density of particles $n$, the cross-section $Σ$, and the average relative speed $v$. In stellar dynamics, this fo…
View article: Optimising Shifted Excitation Raman Difference Spectroscopy (SERDS) for application in highly fluorescent biological samples, using fibre optic probes
Optimising Shifted Excitation Raman Difference Spectroscopy (SERDS) for application in highly fluorescent biological samples, using fibre optic probes Open
Raman spectra of tissues with shifted excitation to remove unwanted background signals.
View article: Identification of tauopathy-associated lipid signatures in Alzheimer’s disease mouse brain using label-free chemical imaging
Identification of tauopathy-associated lipid signatures in Alzheimer’s disease mouse brain using label-free chemical imaging Open
View article: A systematic scoping review exploring variation in practice in specimen mammography for Intraoperative Margin Analysis in Breast Conserving Surgery and the role of artificial intelligence in optimising diagnostic accuracy
A systematic scoping review exploring variation in practice in specimen mammography for Intraoperative Margin Analysis in Breast Conserving Surgery and the role of artificial intelligence in optimising diagnostic accuracy Open
There is marked variation in current techniques used for SM for intraoperative margin analysis with correspondingly disparate DA. Only 1 study applied AI to SMI, and we identify how AI could optimise SMI and a template for future work to a…
View article: Limitations of effective medium models for tissue phantoms in the THz frequency range
Limitations of effective medium models for tissue phantoms in the THz frequency range Open
The absorption of terahertz (THz) radiation by water molecules facilitates its application to several biomedical applications such as cancer detection. Therefore, it is critical for the THz technologies to be characterised with water conte…
View article: Ouroboros: cross-linking protein expression perturbations and cancer histology imaging with generative-predictive modeling
Ouroboros: cross-linking protein expression perturbations and cancer histology imaging with generative-predictive modeling Open
Summary Imagine if we could simultaneously predict spatial protein expression in tissues from their routine Hematoxylin and Eosin (H&E) stained images, and create tissue images given protein expression profiles thus enabling virtual simula…
View article: Active Surface-Enhanced Raman Spectroscopy (SERS): A Novel Concept for Enhancing Signal Contrast in Complex Matrices Using External Perturbation
Active Surface-Enhanced Raman Spectroscopy (SERS): A Novel Concept for Enhancing Signal Contrast in Complex Matrices Using External Perturbation Open
Noninvasive detection of surface-enhanced Raman spectroscopy (SERS) signals from deep within tissue represents a common challenge in many biological and clinical applications including disease diagnosis and therapy monitoring. Such signals…
View article: System transferability of Raman-based oesophageal tissue classification using modern machine learning to support multi-centre clinical diagnostics
System transferability of Raman-based oesophageal tissue classification using modern machine learning to support multi-centre clinical diagnostics Open
View article: Taking a Tailored Approach to Material Design: A Mechanistic Study of the Selective Localization of Phase-Separated Graphene Microdomains
Taking a Tailored Approach to Material Design: A Mechanistic Study of the Selective Localization of Phase-Separated Graphene Microdomains Open
To achieve multifunctional properties using nanocomposites, selectively locating nanofillers in specific areas by tailoring a mixture of two immiscible polymers has been widely investigated. Forming a phase-separated structure from entirel…
View article: Nuclear moments: recent developments
Nuclear moments: recent developments Open
The author has for many years kept a watching brief on the experimental study of nuclear electro-magnetic moments. Accurate values of nuclear magnetic dipole and electric quadrupole moments are a major product and the life blood of hyperfi…
View article: Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification
Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification Open
View article: Guided principal component analysis (GPCA): a simple method for improving detection of a known analyte
Guided principal component analysis (GPCA): a simple method for improving detection of a known analyte Open
Here we propose Guided PCA, a simple approach to ensure the spectrum of a key target moiety is consistly provided in a high ranking principal component.
View article: Microcalcification crystallography as a potential marker of DCIS recurrence
Microcalcification crystallography as a potential marker of DCIS recurrence Open
View article: Issue Information
Issue Information Open
View article: 10 kHz Shifted-Excitation Raman Difference Spectroscopy with Charge-Shifting Charge-Coupled Device Read-Out for Effective Mitigation of Dynamic Interfering Backgrounds
10 kHz Shifted-Excitation Raman Difference Spectroscopy with Charge-Shifting Charge-Coupled Device Read-Out for Effective Mitigation of Dynamic Interfering Backgrounds Open
In this work we demonstrate an advanced concept of a charge-shifting charge-coupled device (CCD) read-out combined with shifted excitation Raman difference spectroscopy (SERDS) capable of operating at up to 10 kHz acquisition rates for the…
View article: Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer
Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer Open
We aim to develop a protocol for efficiently analysing breast microcalcifications and their microenvironment in detail by combining O-PTIR and Raman spectroscopy at the same time, the same location and the same high resolution (0.5 μm).
View article: Contents list
Contents list Open
Permissions Request permissions Contents list Analyst, 2023, 148, 4563 DOI: 10.1039/D3AN90069J This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications…
View article: High wavenumber Raman spectroscopy for intraoperative assessment of breast tumour margins
High wavenumber Raman spectroscopy for intraoperative assessment of breast tumour margins Open
Spectra taken using a HWN Raman probe from bisected mastectomy specimens are capable of identifying tumour versus normal tissue through the difference in water, protein and lipid content.