Nicholas T. Ventham
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View article: Survival outcomes in patients with sigmoid volvulus
Survival outcomes in patients with sigmoid volvulus Open
Aim This study aimed to assess management pathways and outcomes in sigmoid volvulus (SV). Methods A retrospective review was performed on patients first admitted with SV between 2019 and 2023 within a tertiary-level colorectal service. Dem…
View article: Twenty‐Year Trends in Colectomy Rates and Advanced Therapy Prescribing in Lothian, Scotland
Twenty‐Year Trends in Colectomy Rates and Advanced Therapy Prescribing in Lothian, Scotland Open
Background The impact of advanced therapy prescribing on colectomy rates in ulcerative colitis (UC) is unknown with conflicting published evidence. Aim To describe advanced therapy prescribing trends and colectomy rates for patients with U…
View article: The significance of microscopically positive lymph node margins (<scp>R1</scp>) following surgical resection for Stage <scp>III</scp> colon cancer—A retrospective, observational study
The significance of microscopically positive lymph node margins (<span>R1</span>) following surgical resection for Stage <span>III</span> colon cancer—A retrospective, observational study Open
Aim Microscopically positive resection margins (R1) are associated with poorer outcomes in colon cancer. While the sequalae of a positive margin related to the primary tumour (R1Tumour) are relatively well known, comparatively less is know…
View article: The Circulating Methylome in Childhood-Onset Inflammatory Bowel Disease
The Circulating Methylome in Childhood-Onset Inflammatory Bowel Disease Open
Background The genetic contribution to inflammatory bowel disease (IBD), encompassing both Crohn’s disease (CD) and ulcerative colitis (UC), accounts for around 20% of disease variance, highlighting the need to characterize environmental a…
View article: Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease
Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease Open
This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking …
View article: DOP55 High diagnostic accuracy of 4-probe methylation biomarkers in paediatric Inflammatory Bowel Disease by epigenome-wide analysis
DOP55 High diagnostic accuracy of 4-probe methylation biomarkers in paediatric Inflammatory Bowel Disease by epigenome-wide analysis Open
Background The application of -omics technology offers important opportunities for biomarker discovery to personalise management of patients with inflammatory bowel disease (IBD). In previous work, we reported a characteristic profile of g…
View article: Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer
Double faecal immunochemical testing in patients with symptoms suspicious of colorectal cancer Open
Background Faecal immunochemical test (FIT)-directed pathways based on a single test have been implemented for symptomatic patients. However, with a single test, the sensitivity is 87 per cent at 10 µg haemoglobin (Hb) per g faeces. This a…
View article: Source data for the project entitled "Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediate the effect of smoking on inflammatory bowel disease"
Source data for the project entitled "Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediate the effect of smoking on inflammatory bowel disease" Open
In this study, we aim first to assess the association between cigarette smoking and the risk of IBD through a prospective cohort study in the UK Biobank. Then, we evaluate the potential causal association between smoking behaviors and smok…
View article: Analysis of Systemic Epigenetic Alterations in Inflammatory Bowel Disease: Defining Geographical, Genetic and Immune-Inflammatory influences on the Circulating Methylome
Analysis of Systemic Epigenetic Alterations in Inflammatory Bowel Disease: Defining Geographical, Genetic and Immune-Inflammatory influences on the Circulating Methylome Open
Background Epigenetic alterations may provide valuable insights into gene–environment interactions in the pathogenesis of inflammatory bowel disease [IBD]. Methods Genome-wide methylation was measured from peripheral blood using the Illumi…
View article: Systematic Review and Meta-analysis of Peripheral Blood DNA Methylation Studies in Inflammatory Bowel Disease
Systematic Review and Meta-analysis of Peripheral Blood DNA Methylation Studies in Inflammatory Bowel Disease Open
Background and Aims Over the past decade, the DNA methylome has been increasingly studied in peripheral blood of inflammatory bowel disease [IBD] patients. However, a comprehensive summary and meta-analysis of peripheral blood leukocyte [P…
View article: SP3.1.10 The use of predictive severity scoring for lower gastrointestinal bleeding in a tertiary colorectal unit
SP3.1.10 The use of predictive severity scoring for lower gastrointestinal bleeding in a tertiary colorectal unit Open
Introduction Lower GI bleeding (LGIB) has an estimated 1-year prevalence of 10% in the UK, accounting for 3% of emergency surgical referrals. The British Society of Gastroenterology (BSG) recommend risk scoring for LGIB to categorise sever…
View article: Characterisation of the Circulating Transcriptomic Landscape in Inflammatory Bowel Disease Provides Evidence for Dysregulation of Multiple Transcription Factors Including NFE2, SPI1, CEBPB, and IRF2
Characterisation of the Circulating Transcriptomic Landscape in Inflammatory Bowel Disease Provides Evidence for Dysregulation of Multiple Transcription Factors Including NFE2, SPI1, CEBPB, and IRF2 Open
Aim To assess the pathobiological and translational importance of whole-blood transcriptomic analysis in inflammatory bowel disease [IBD]. Methods We analysed whole-blood expression profiles from paired-end sequencing in a discovery cohort…
View article: Open extent IV thoracoabdominal aneurysm repair: 22-year experience of the Scottish National Service
Open extent IV thoracoabdominal aneurysm repair: 22-year experience of the Scottish National Service Open
Background Since 1999, the Scottish National Service for Thoracoabdominal Aneurysms has offered repair of thoracoabdominal aneurysms (TAAAs) to a population of 5.5 million people. The open operation most commonly performed by the service i…
View article: OMO-1 Epigenetic alterations in IBD: defining geographical, genetic, and immune-inflammatory influences on the circulating methylome
OMO-1 Epigenetic alterations in IBD: defining geographical, genetic, and immune-inflammatory influences on the circulating methylome Open
Introduction DNA methylation may provide critical insights into gene-environment interactions in inflammatory bowel disease (IBD). Methods Using the multi-centre IBD Character inception cohort (295 controls, 154 CD, 161 UC, 28 IBD-U), epig…
View article: TP6.2.2 Multi-disciplinary interventions to increase utilisation of NELA scores and critical care involvement following emergency colorectal surgery
TP6.2.2 Multi-disciplinary interventions to increase utilisation of NELA scores and critical care involvement following emergency colorectal surgery Open
Aims This audit aimed to assess pre-operative NELA risk score documentation and subsequent specialist peri-operative critical care involvement. Methods This complete audit cycle retrospectively reviewed notes (electronic patient records, a…
View article: EP.FRI.704 Emergency colorectal surgery outcomes within a non-specialist split site service – a retrospective cohort study
EP.FRI.704 Emergency colorectal surgery outcomes within a non-specialist split site service – a retrospective cohort study Open
Aims Within this region, Upper GI and Colorectal subspecialties are located at separate hospitals. This study aims to determine outcomes of critically unwell patients undergoing emergency colorectal surgery off-site at the non-colorectal s…
View article: Serum N-Glycomic Biomarkers Predict Treatment Escalation in Inflammatory Bowel Disease
Serum N-Glycomic Biomarkers Predict Treatment Escalation in Inflammatory Bowel Disease Open
A blood-based prognostic biomarker to guide clinical decision-making at diagnosis of inflammatory bowel disease (IBD) would be immensely helpful. We investigated a composite serum N-glycomic biomarker to predict future disease course in 24…
View article: Analysis of systemic epigenetic alterations in inflammatory bowel disease: defining geographical, genetic, and immune-inflammatory influences on the circulating methylome
Analysis of systemic epigenetic alterations in inflammatory bowel disease: defining geographical, genetic, and immune-inflammatory influences on the circulating methylome Open
Gene-environment interactions play a pivotal role in the pathogenesis of Inflammatory Bowel Disease (IBD). Using the IBD Character inception cohort (295 controls, 154 CD, 161 UC, 28 IBD-U) we confirm the presence of a highly characteristic…
View article: O14 Whole blood profiling of T-cell derived miRNA allows the development of prognostic models in IBD
O14 Whole blood profiling of T-cell derived miRNA allows the development of prognostic models in IBD Open
Introduction There is an unmet need for blood-based biomarkers that help predict disease and its course at inception to allow tailoring of treatments, achieve early mucosal healing and improve clinical outcomes. In our study, we explore th…
View article: Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease
Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease Open
Background Success in personalized medicine in complex disease is critically dependent on biomarker discovery. We profiled serum proteins using a novel proximity extension assay [PEA] to identify diagnostic and prognostic biomarkers in inf…
View article: Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease
Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease Open
Summary Background Success in personalised medicine in complex disease is critically dependent on biomarker discovery. We profiled serum proteins using a novel proximity extension assay (PEA) to identify diagnostic and prognostic biomarker…
View article: Acute colonic obstruction within a congenital Bochdalek diaphragmatic hernia following colonoscopy
Acute colonic obstruction within a congenital Bochdalek diaphragmatic hernia following colonoscopy Open
A 57-year-old female presented 6 days following colonoscopy with bowel obstruction. She had not passed wind or bowel motion since the endoscopy. She visited a general practitioner with right shoulder pain three days following the procedure…
View article: Whole Blood Profiling of T-cell-Derived microRNA Allows the Development of Prognostic models in Inflammatory Bowel Disease
Whole Blood Profiling of T-cell-Derived microRNA Allows the Development of Prognostic models in Inflammatory Bowel Disease Open
Background MicroRNAs [miRNAs] are cell-specific small non-coding RNAs that can regulate gene expression and have been implicated in inflammatory bowel disease [IBD] pathogenesis. Here we define the cell-specific miRNA profiles and investig…
View article: DOP10 Serum N-glycomic biomarkers predict treatment escalation in inflammatory bowel disease
DOP10 Serum N-glycomic biomarkers predict treatment escalation in inflammatory bowel disease Open
Biomarkers to predict treatment response would be highly beneficial in the clinical management of inflammatory bowel disease (IBD). To that end we have investigated the validity of a composite N-glycomic biomarker from 10 µl of serum taken…