Nicholas T. Vozoris
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View article: Impact of Cannabis Smoking on Multiple Sleep Latency Test Outcomes
Impact of Cannabis Smoking on Multiple Sleep Latency Test Outcomes Open
Our purpose was to evaluate how cannabis smoking influenced multiple sleep latency test (MSLT) outcomes. This was a retrospective study of all adults that had undergone a MSLT at St. Michael's Hospital (Toronto, Ontario, Canada) from 1 Jan…
View article: Health outcomes following COVID-19 infection and vaccination in hereditary hemorrhagic telangiectasia
Health outcomes following COVID-19 infection and vaccination in hereditary hemorrhagic telangiectasia Open
Background There has been concern that individuals living with Hereditary Hemorrhagic Telangiectasia (HHT) could be at higher risk for poor outcomes if infected with SARS-CoV2, the virus that causes COVID-19 disease. As literature is lacki…
View article: Mode of delivery and birth outcomes before and during COVID-19 –A population-based study in Ontario, Canada
Mode of delivery and birth outcomes before and during COVID-19 –A population-based study in Ontario, Canada Open
There is lack of clarity on whether pregnancies during COVID-19 resulted in poorer mode of delivery and birth outcomes in Ontario, Canada. We aimed to compare mode of delivery (C-section), birth (low birthweight, preterm birth, NICU admiss…
View article: Health Outcomes Following Covid-19 Infection and Vaccination in Hereditary Hemorrhagic Telangiectasia
Health Outcomes Following Covid-19 Infection and Vaccination in Hereditary Hemorrhagic Telangiectasia Open
Background: There has been concern that individuals living with Hereditary Hemorrhagic Telangiectasia (HHT) could be at higher risk for poor outcomes if infected with SARS-CoV2, the virus that causes COVID-19 disease. As literature is lack…
View article: 605 Description of sleep breathing disorder prevalence, risk factors, and treatment in adults with cystic fibrosis
605 Description of sleep breathing disorder prevalence, risk factors, and treatment in adults with cystic fibrosis Open
View article: An analysis of sex differences in pulmonary arteriovenous malformation presentation, complications and management in a large, multinational registry of patients with hereditary haemorrhagic telangiectasia
An analysis of sex differences in pulmonary arteriovenous malformation presentation, complications and management in a large, multinational registry of patients with hereditary haemorrhagic telangiectasia Open
This large, multinational, sex-based analysis among individuals with HHT showed that pulmonary AVM frequency, physical characteristics, presentation, complications and management do not generally significantly differ between males and f…
View article: Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasia
Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasia Open
View article: Sleep health and race: little-chartered territory
Sleep health and race: little-chartered territory Open
View article: Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study
Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study Open
Introduction Although cannabis is frequently used worldwide, its impact on respiratory health is characterised by controversy. Objective To evaluate the association between cannabis use and respiratory-related emergency room (ER) visits an…
View article: Neurovascular Complications and Pulmonary Arteriovenous Malformation Feeding Artery Size
Neurovascular Complications and Pulmonary Arteriovenous Malformation Feeding Artery Size Open
"Neurovascular Complications and Pulmonary Arteriovenous Malformation Feeding Artery Size." Annals of the American Thoracic Society, 19(8), pp. 1432–1435
View article: Morbidity and mortality reduction associated with polysomnography testing in idiopathic pulmonary fibrosis: a population-based cohort study
Morbidity and mortality reduction associated with polysomnography testing in idiopathic pulmonary fibrosis: a population-based cohort study Open
View article: Does Vaping Increase the Odds of Asthma?: A Canadian Community Health Survey Study
Does Vaping Increase the Odds of Asthma?: A Canadian Community Health Survey Study Open
Rationale: While vaping is thought to be a safer alternative to smoking, emerging research suggests that e-cigarette (EC) use may have long-term health effects and may worsen pre-existing health conditions such as asthma.The objective of t…
View article: Weekly epistaxis duration as an indicator of epistaxis severity in hereditary hemorrhagic telangiectasia—Preliminary results from a randomized controlled trial
Weekly epistaxis duration as an indicator of epistaxis severity in hereditary hemorrhagic telangiectasia—Preliminary results from a randomized controlled trial Open
Objectives There is great interest in developing and studying novel therapies for epistaxis in hereditary hemorrhagic telangiectasia (HHT) given its associated morbidity and impact on patients' quality of life. Several recent randomized co…
View article: Morbidity and Mortality Reduction Associated with Polysomnography Testing in Idiopathic Pulmonary Fibrosis: A Population-Based Cohort Study
Morbidity and Mortality Reduction Associated with Polysomnography Testing in Idiopathic Pulmonary Fibrosis: A Population-Based Cohort Study Open
Background: It is not well-known if diagnosing and treating sleep breathing disorders among individuals with idiopathic pulmonary fibrosis (IPF) improves health outcomes. We evaluated the association between receipt of laboratory-based pol…
View article: Opioids for Dyspnea in Chronic Obstructive Pulmonary Disease: Short on the Details
Opioids for Dyspnea in Chronic Obstructive Pulmonary Disease: Short on the Details Open
View article: Morbidity and mortality associated with prescription cannabinoid drug use in COPD
Morbidity and mortality associated with prescription cannabinoid drug use in COPD Open
Introduction Respiratory-related morbidity and mortality were evaluated in relation to incident prescription oral synthetic cannabinoid (nabilone, dronabinol) use among older adults with chronic obstructive pulmonary disease (COPD). Method…
View article: Position statement from the Canadian Thoracic Society (CTS) on clinical triage thresholds in respiratory disease patients in the event of a major surge during the COVID-19 pandemic
Position statement from the Canadian Thoracic Society (CTS) on clinical triage thresholds in respiratory disease patients in the event of a major surge during the COVID-19 pandemic Open
With the rapid rise in cases of COVID-19 across the world, health systems face unprecedented challenges in the delivery of patient care. This includes constrained capacity for intensive care unit (...
View article: Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge
Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge Open
View article: Opioid utility for dyspnea in chronic obstructive pulmonary disease: a complicated and controversial story
Opioid utility for dyspnea in chronic obstructive pulmonary disease: a complicated and controversial story Open
Chronic obstructive pulmonary disease (COPD) is common chronic respiratory disorder, predominantly caused by exposure to cigarette smoke or biomass fuels, and it usually affects older adults. Dyspnea in COPD that is unresponsive to traditi…
View article: Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Bi-allelic Loss of ENG or ACVRL1
Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Bi-allelic Loss of ENG or ACVRL1 Open
View article: Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Biallelic Loss of <i>ENG</i> or <i>ACVRL1</i>
Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Biallelic Loss of <i>ENG</i> or <i>ACVRL1</i> Open
Hereditary Hemorrhagic Telangiectasia (HHT) is a Mendelian disease characterized by vascular malformations including visceral arteriovenous malformations and mucosal telangiectasia. HHT is caused by loss-of-function mutations in one of 3 g…
View article: Socioeconomic status (SES) and 30-day hospital readmissions for chronic obstructive pulmonary (COPD) disease: A population-based cohort study
Socioeconomic status (SES) and 30-day hospital readmissions for chronic obstructive pulmonary (COPD) disease: A population-based cohort study Open
Socioeconomic status, measured in various ways, and many comorbidities predict 30-day readmission or death in patients hospitalized for COPD. Strategies that address these factors may help reduce readmissions and death.
View article: Benzodiazepine and opioid co-usage in the US population, 1999–2014: an exploratory analysis
Benzodiazepine and opioid co-usage in the US population, 1999–2014: an exploratory analysis Open
In this exploratory analysis, concurrent use of benzodiazepine receptor modulators and opioids, and nonselective and selective benzodiazepine receptor modulators, was found to have progressively risen in the United States. The progressive …
View article: Statistical compared to clinical significance and the risk of misattribution
Statistical compared to clinical significance and the risk of misattribution Open
We thank M. Ekström and colleagues for their interest in our study [1] and for their comments. The central concepts that M. Ekström and colleagues express in their correspondence are that our findings of increased respiratory-related morbi…
View article: Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia
Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia Open
Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, op…
View article: Serotonergic antidepressant use and morbidity and mortality among older adults with COPD
Serotonergic antidepressant use and morbidity and mortality among older adults with COPD Open
We evaluated the relationship between new selective serotonin reuptake inhibitor (SSRI) or serotonin–noradrenaline reuptake inhibitor (SNRI) drug use and respiratory-related morbidity and mortality among older adults with chronic obstructi…
View article: Incident diuretic drug use and adverse respiratory events among older adults with chronic obstructive pulmonary disease
Incident diuretic drug use and adverse respiratory events among older adults with chronic obstructive pulmonary disease Open
Aims Diuretic drugs may theoretically improve respiratory health outcomes in chronic obstructive pulmonary disease (COPD) through several possible mechanisms, but they might also lead to respiratory harm. We evaluated the association of in…
View article: Prescription opioid use in advanced COPD: benefits, perils and controversies
Prescription opioid use in advanced COPD: benefits, perils and controversies Open
In the ancient Roman literary masterpiece Metamorphoses , the poet Ovid writes that the god of sleep, Somnus (who had a twin brother named Thanatos, or Death), lived in a dark cave and "in front of the cave mouth a wealth of poppies flouri…
View article: The harms of benzodiazepines for patients with dementia
The harms of benzodiazepines for patients with dementia Open
[See related article at [www.cmaj.ca/lookup/doi/10.1503/cmaj.160126][2]][2] A wide spectrum of neuropsychiatric symptoms may develop in people with dementia. These symptoms can cause distress to families and caregivers and are challenging …
View article: Incident opioid use is associated with risk of respiratory harm in non-palliative COPD
Incident opioid use is associated with risk of respiratory harm in non-palliative COPD Open
We thank M. Ekström and co-workers for their interest in our manuscript [1] and for their contributions to the important topic of opioid drug use in chronic obstructive pulmonary disease (COPD). M. Ekström and co-workers stress the efficac…