Nicholas Tolman
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View article: Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment
Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment Open
Since the trabecular meshwork (TM) is central to intraocular pressure (IOP) regulation and glaucoma, a deeper understanding of its genomic landscape is needed. We present a multimodal, single-cell resolution analysis of mouse limbal cells …
View article: Absence of Glaucoma in Tg-<i>MYOC<sup>Y437H</sup></i> Mice of Diverse Genetic Backgrounds
Absence of Glaucoma in Tg-<i>MYOC<sup>Y437H</sup></i> Mice of Diverse Genetic Backgrounds Open
Our data indicate undefined complexity and that the previously reported glaucoma phenotypes are not robust across all institutions and environments.
View article: Single-Cell Characterization of Anterior Segment Development: Cell Types, Pathways, and Signals Driving Formation of the Trabecular Meshwork and Schlemm’s Canal
Single-Cell Characterization of Anterior Segment Development: Cell Types, Pathways, and Signals Driving Formation of the Trabecular Meshwork and Schlemm’s Canal Open
Morphogenesis of the anterior segment (AS) is crucial for healthy ocular physiology and vision but is only partially understood. The Schlemm’s canal (SC) and trabecular meshwork (TM) are essential drainage tissues within the AS, and their …
View article: Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment
Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment Open
Since the trabecular meshwork (TM) is central to intraocular pressure (IOP) regulation and glaucoma, a deeper understanding of its genomic landscape is needed. We present a multimodal, single-cell resolution analysis of mouse limbal cells …
View article: Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment
Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment Open
Since the trabecular meshwork (TM) is central to intraocular pressure (IOP) regulation and glaucoma, a deeper understanding of its genomic landscape is needed. We present a multimodal, single-cell resolution analysis of mouse limbal cells …
View article: Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma
Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma Open
A glaucoma polygenic risk score (PRS) can effectively identify disease risk, but some individuals with high PRS do not develop glaucoma. Factors contributing to this resilience remain unclear. Using 4,658 glaucoma cases and 113,040 control…
View article: Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma
Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma Open
A glaucoma polygenic risk score (PRS) can effectively identify disease risk, but some individuals with high PRS do not develop glaucoma. Factors contributing to this resilience remain unclear. Using 4,658 glaucoma cases and 113,040 control…
View article: Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma
Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma Open
Glaucoma polygenic risk scores (PRS) effectively identify disease risk, but some individuals with high PRS do not develop glaucoma. Factors contributing to this resilience remain unclear. Using 4,658 glaucoma cases and 113,040 controls in …
View article: Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma
Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma Open
A glaucoma polygenic risk score (PRS) can effectively identify disease risk, but some individuals with high PRS do not develop glaucoma. Factors contributing to this resilience remain unclear. Using 4,658 glaucoma cases and 113,040 control…
View article: Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma
Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma Open
A glaucoma polygenic risk score (PRS) can effectively identify disease risk, but some individuals with high PRS do not develop glaucoma. Factors contributing to this resilience remain unclear. Using 4,658 glaucoma cases and 113,040 control…
View article: Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment
Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment Open
Since the trabecular meshwork (TM) is central to intraocular pressure (IOP) regulation and glaucoma, a deeper understanding of its genomic landscape is needed. We present a multimodal, single-cell resolution analysis of mouse limbal cells …
View article: IOP-induced blood-retinal barrier compromise contributes to RGC death in glaucoma
IOP-induced blood-retinal barrier compromise contributes to RGC death in glaucoma Open
The integrity of the blood-retinal barrier (BRB) has been largely unexplored in glaucoma. We reveal that elevated intraocular pressure (IOP) partially compromises the BRB in two human-relevant inherited mouse models of glaucoma (DBA/2J and…
View article: Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states Open
Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functio…
View article: Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states Open
Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functio…
View article: Reviewer #1 (Public Review): Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
Reviewer #1 (Public Review): Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states Open
Schlemm's canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm's canal endothelial cells (SECs) with different morphologies and functio…
View article: Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states Open
Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functio…
View article: Author response: Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
Author response: Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states Open
Schlemm's canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm's canal endothelial cells (SECs) with different morphologies and functio…
View article: Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states Open
Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functio…
View article: Reviewer #2 (Public Review): Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
Reviewer #2 (Public Review): Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states Open
Schlemm's canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm's canal endothelial cells (SECs) with different morphologies and functio…
View article: Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states Open
Schlemm’s canal (SC) is central in intraocular pressure regulation but requires much characterization. It has distinct inner and outer walls, each composed of Schlemm’s canal endothelial cells (SECs) with different morphologies and functio…
View article: Genetic background modifies vulnerability to glaucoma-related phenotypes in <i>Lmx1b</i> mutant mice
Genetic background modifies vulnerability to glaucoma-related phenotypes in <i>Lmx1b</i> mutant mice Open
Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals. …
View article: Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure
Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure Open
Glaucoma is a leading cause of blindness affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. Inefficient aqueous humor (AqH) outflow resulting from structural or functional alte…