Nicholas Wettersten
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View article: Do I really need to be admitted? A case for more outpatient therapies for acute decompensated heart failure
Do I really need to be admitted? A case for more outpatient therapies for acute decompensated heart failure Open
View article: Albuminuria is associated with worse outcomes in non‐diabetics hospitalized with acute heart failure
Albuminuria is associated with worse outcomes in non‐diabetics hospitalized with acute heart failure Open
Aims Chronic kidney disease (CKD) increases the risk of morbidity and mortality in patients with heart failure (HF). Guidelines recommend assessing CKD using the urinary albumin‐to‐creatinine ratio (UACR), as albuminuria is strongly associ…
View article: Plasma Biomarkers of Kidney Tubule Health during Ambulatory AKI and Kidney Function Recovery in SPRINT
Plasma Biomarkers of Kidney Tubule Health during Ambulatory AKI and Kidney Function Recovery in SPRINT Open
Key Points AKI frequently occurs in the ambulatory setting, but there are no available tools to distinguish whether kidney function will recover. Plasma biomarkers reflecting kidney tubular injury and dysfunction measured at the time of AK…
View article: Kidney Tubular Biomarkers Predict Risk of Death and Heart Failure Readmission in Acute Heart Failure
Kidney Tubular Biomarkers Predict Risk of Death and Heart Failure Readmission in Acute Heart Failure Open
Background Kidney dysfunction, defined by measures of glomerular health, in patients hospitalized with acute heart failure (HF) is associated with death and HF readmission. We aimed to determine if kidney tubule damage and dysfunction are …
View article: Galectin-3 Is Associated With Risk of Cardiovascular and Kidney Outcomes in Ambulatory Veterans
Galectin-3 Is Associated With Risk of Cardiovascular and Kidney Outcomes in Ambulatory Veterans Open
Gal-3 is associated with risk of cardiovascular and kidney outcomes among ambulatory Veterans.
View article: Days alive and out of the hospital at 1 year following heart transplant: Comparing donation after brain death versus after circulatory death
Days alive and out of the hospital at 1 year following heart transplant: Comparing donation after brain death versus after circulatory death Open
View article: Association of Plasma KIM-1, TNFR-1, and TNFR-2 With Cardiovascular Outcomes and All-Cause Mortality in Individuals With Chronic Kidney Disease: An Ancillary Analysis of SPRINT
Association of Plasma KIM-1, TNFR-1, and TNFR-2 With Cardiovascular Outcomes and All-Cause Mortality in Individuals With Chronic Kidney Disease: An Ancillary Analysis of SPRINT Open
In individuals with hypertension and nondiabetic CKD, associations of higher plasma KIM-1, TNFR-1, and TNFR-2 concentrations with CVD events were not independent of eGFR and albuminuria, whereas higher levels of plasma KIM-1 and TNFR-1 wer…
View article: Associations of Urine Biomarkers During Ambulatory Acute Kidney Injury With Subsequent Recovery in Kidney Function: Findings From the SPRINT Study
Associations of Urine Biomarkers During Ambulatory Acute Kidney Injury With Subsequent Recovery in Kidney Function: Findings From the SPRINT Study Open
Increases in serum creatinine concentration can occur when treating hypertension and complicate clinical management, but there are few tools available to distinguish whether an individual's kidney function will subsequently recover. In thi…
View article: Surveillance donor-specific antibody and pathologic antibody-mediated rejection testing in heart transplant patients in the contemporary era
Surveillance donor-specific antibody and pathologic antibody-mediated rejection testing in heart transplant patients in the contemporary era Open
View article: Racial differences in diuretic therapy, B-type natriuretic peptide values, and prognosis in acute heart failure
Racial differences in diuretic therapy, B-type natriuretic peptide values, and prognosis in acute heart failure Open
View article: Association between Proenkephalin A and cardiovascular outcomes in ambulatory Veterans
Association between Proenkephalin A and cardiovascular outcomes in ambulatory Veterans Open
View article: Absence of Kidney Tubular Injury in Patients With Acute Heart Failure With Acute Kidney Injury
Absence of Kidney Tubular Injury in Patients With Acute Heart Failure With Acute Kidney Injury Open
BACKGROUND: Worsening renal function (WRF) is common in hospitalized patients being treated for acute heart failure. However, discriminating clinically significant WRF remains challenging. In patients hospitalized with acute heart failure,…
View article: Significance of an Early Repeat Troponin Measurement Upon Presentation to the Hospital for Acute Heart Failure
Significance of an Early Repeat Troponin Measurement Upon Presentation to the Hospital for Acute Heart Failure Open
Background Higher cardiac troponin is associated with worse outcomes in patients with acute heart failure. The significance of repeat measurements over hours remains unclear. We assessed whether a repeat measurement and the Δ between measu…
View article: Variation of NT-proBNP and High-Sensitivity Cardiac Troponin T Across Levels of Estimated Glomerular Filtration Rate: The SPRINT Trial
Variation of NT-proBNP and High-Sensitivity Cardiac Troponin T Across Levels of Estimated Glomerular Filtration Rate: The SPRINT Trial Open
View article: Cardiac allograft vasculopathy outcomes among donation after circulatory death heart transplant recipients
Cardiac allograft vasculopathy outcomes among donation after circulatory death heart transplant recipients Open
In DCD heart transplant recipients, circulatory death donors did not have a significantly higher risk for coronary allograft vasculopathy by IVUS or related complications at 1 year following transplantation.
View article: Incidence of Acute Rejection Compared With Endomyocardial Biopsy Complications for Heart Transplant Patients in the Contemporary Era
Incidence of Acute Rejection Compared With Endomyocardial Biopsy Complications for Heart Transplant Patients in the Contemporary Era Open
Background. The reference standard of detecting acute rejection (AR) in adult heart transplant (HTx) patients is an endomyocardial biopsy (EMB). The majority of EMBs are performed in asymptomatic patients. However, the incidence of treated…
View article: Donor-Specific Antibody Testing is an Effective Surveillance Strategy for High-Risk Antibody Mediated Rejection in Heart Transplant Patients in the Contemporary Era
Donor-Specific Antibody Testing is an Effective Surveillance Strategy for High-Risk Antibody Mediated Rejection in Heart Transplant Patients in the Contemporary Era Open
Background: Pathologic antibody mediated rejection (pAMR) evaluation and donor specific antibody (DSA) testing are recommended in the first year after heart transplantation (HTx) in adult patients. Whether DSA testing adds prognostic infor…
View article: Changes in Natriuretic Peptide Levels and Subsequent Kidney Function Decline in SPRINT
Changes in Natriuretic Peptide Levels and Subsequent Kidney Function Decline in SPRINT Open
N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker in the blood that reflects mechanical stress on the heart. Measuring NT-proBNP may be helpful in assessing the risk of long-term losses of kidney function. In this study,…
View article: The Mounting Evidence for Permissive Hypercreatinemia in Acute Heart Failure: Adding Sodium Glucose Cotransporter Inhibitors to the List
The Mounting Evidence for Permissive Hypercreatinemia in Acute Heart Failure: Adding Sodium Glucose Cotransporter Inhibitors to the List Open
Sodium/glucose cotransporter 2 inhibitors (SGLT2is) have been a pharmacologic breakthrough in the management of CKD and heart failure (HF). However, with their relative newness in clinical use, these agents are frequently held because of c…
View article: ‘Don’t Throw the Baby out With the Bathwater’ Urine Galectin-3 in Heart Failure With Chronic Kidney Disease: Another Tool to Distinguish Intrinsic Kidney Disease From Chronic, Functional Cardiorenal Syndrome?
‘Don’t Throw the Baby out With the Bathwater’ Urine Galectin-3 in Heart Failure With Chronic Kidney Disease: Another Tool to Distinguish Intrinsic Kidney Disease From Chronic, Functional Cardiorenal Syndrome? Open
View article: Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD
Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD Open
Key Points Higher plasma and urine kidney injury molecule-1, urine monocyte chemoattractant protein-1, and lower urine alpha-1-microglobulin were associated with left ventricular hypertrophy, even after adjustment for confounders. Biomarke…
View article: Benefit versus Risk of Endomyocardial Biopsy for Heart Transplant Patients in the Contemporary Era
Benefit versus Risk of Endomyocardial Biopsy for Heart Transplant Patients in the Contemporary Era Open
Background The reference standard of detecting acute rejection (AR) in adult heart transplant (HTx) patients is an endomyocardial biopsy (EMB). The majority of EMBs are performed in asymptomatic patients. However, the benefit of diagnosing…
View article: Contents
Contents Open
View article: The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure
The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure Open
View article: Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis
Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis Open
View article: Implications of worsening renal function before hospitalization for acute heart failure
Implications of worsening renal function before hospitalization for acute heart failure Open
Aims Kidney function changes dynamically during AHF treatment, but risk factors for and consequences of worsening renal function (WRF) at hospital admission are uncertain. We aimed to determine the significance of WRF at admission for acut…
View article: Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure
Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure Open
View article: Growth hormone concentration and risk of all-cause and cardiovascular mortality: The REasons for Geographic And Racial Disparities in Stroke (REGARDS) study
Growth hormone concentration and risk of all-cause and cardiovascular mortality: The REasons for Geographic And Racial Disparities in Stroke (REGARDS) study Open
View article: Kidney Function Specific Reference Limits for N-terminal Pro Brain Natriuretic Peptide and High Sensitivity Troponin T: The Systolic Blood Pressure Intervention Trial
Kidney Function Specific Reference Limits for N-terminal Pro Brain Natriuretic Peptide and High Sensitivity Troponin T: The Systolic Blood Pressure Intervention Trial Open
Cardiac-specific biomarkers N-terminal pro brain natriuretic peptide (NT-proBNP) and high sensitivity cardiac troponin T (hsTnT) are widely used for the diagnosis of acute heart failure and myocardial infarction.1Katus H.A. Remppis A. Neum…
View article: Decongestion, kidney injury and prognosis in patients with acute heart failure
Decongestion, kidney injury and prognosis in patients with acute heart failure Open