Nicholas A. Wright
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View article: Central cytometabolic functional vascular coupling in health and disease
Central cytometabolic functional vascular coupling in health and disease Open
The neurovascular unit includes multiple cell types that communicate with each other on a second-by-second basis using traditional neurotransmitters and other signaling molecules, however the function of each cell or the mechanisms by whic…
View article: Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease
Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease Open
Hyperhomocysteinemia (HHcy)-inducing diets recapitulate cerebral small vessel disease phenotypes in mice including cerebrovascular pathology/dysfunction, neuroinflammation, synaptic deficits, and cognitive decline. We recently showed that …
View article: Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium
Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium Open
INTRODUCTION Evidence points to dysregulated Ca 2+ in neurons and astrocytes in models of amyloidosis. While most of these data were obtained in vitro or in vivo under anesthesia, less work has investigated these variables in awake ambulat…
View article: Developing a physiological sciences network: advancing allied professions in cardiac sciences
Developing a physiological sciences network: advancing allied professions in cardiac sciences Open
Background Development of Physiological Science (PS) Networks in the United Kingdom is guided by a 2023 strategic framework aimed at enhancing diagnostic services and patient care through collaboration and a systems approach. Objectives ar…
View article: Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett’s esophagus through progression to cancer
Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett’s esophagus through progression to cancer Open
Barrett’s esophagus (BE), a metaplastic condition that is the only known precursor for esophageal adenocarcinoma (EAC), is relatively common, but progression to cancer is infrequent. BE is inflamed but the contribution of the immune system…
View article: Targeted gene transfer into developmentally defined cell populations of the primate brain
Targeted gene transfer into developmentally defined cell populations of the primate brain Open
The primate brain possesses unique physiological and developmental features whose systematic investigation is hampered by a paucity of transgenic germline models and tools. Here, we present a minimally invasive method to introduce transgen…
View article: Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis
Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis Open
Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and difficult to predict. This is a major chal…
View article: Astrocyte selective insulin receptor knockout in the 5xFAD model of amyloidosis
Astrocyte selective insulin receptor knockout in the 5xFAD model of amyloidosis Open
Background We have recently published that overexpressing a constitutively active form of the insulin receptor beta subunit (IR‐β) in hippocampal neurons ameliorates spatial memory performance in the F344 rat model of aging (Frazier et al.…
View article: Low coverage whole genome sequencing of low-grade dysplasia strongly predicts colorectal cancer risk in ulcerative colitis
Low coverage whole genome sequencing of low-grade dysplasia strongly predicts colorectal cancer risk in ulcerative colitis Open
Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal cancer (CRC), and this risk increases dramatically in those who develop low-grade dysplasia (LGD). However, there is currently no accurate way to risk-strat…
View article: Developing a User-Friendly Oropharyngeal HPV-16 Point-of-Care Diagnostic: HPV-16 Virus Detection in Oral Rinse Sample Matrix With Colorimetric Loop-Mediated Isothermal Amplification
Developing a User-Friendly Oropharyngeal HPV-16 Point-of-Care Diagnostic: HPV-16 Virus Detection in Oral Rinse Sample Matrix With Colorimetric Loop-Mediated Isothermal Amplification Open
Human papillomavirus type 16 (HPV-16) is a highly carcinogenic variant that is responsible for the majority of human oropharyngeal cancers. HPV-16 is critically under-tested, and there are currently no commercially available HPV-16 diagnos…
View article: O-TALC: Steps Towards Combating Oversegmentation within Online Action Segmentation
O-TALC: Steps Towards Combating Oversegmentation within Online Action Segmentation Open
Online temporal action segmentation shows a strong potential to facilitate many HRI tasks where extended human action sequences must be tracked and understood in real time. Traditional action segmentation approaches, however, operate in an…
View article: Editorial: Clinical utilization of plant-based nutrition and fasting protocols as novel therapies
Editorial: Clinical utilization of plant-based nutrition and fasting protocols as novel therapies Open
EDITORIAL article Front. Nutr., 13 March 2024Sec. Clinical Nutrition Volume 11 - 2024 | https://doi.org/10.3389/fnut.2024.1390857
View article: Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study
Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study Open
Purpose Digistain Index (DI), measured using an inexpensive mid-infrared spectrometer, reflects the level of aneuploidy in unstained tissue sections and correlates with tumor grade. We investigated whether incorporating DI with other clini…
View article: The Effects of Signal-to-Noise Ratio on Generative Adversarial Networks Applied to Marine Bioacoustic Data
The Effects of Signal-to-Noise Ratio on Generative Adversarial Networks Applied to Marine Bioacoustic Data Open
In recent years generative adversarial networks (GANs) have been used to supplement datasets within the field of marine bioacoustics. This is driven by factors such as the cost to collect data, data sparsity and aid preprocessing. One nota…
View article: Conserving nature's chorus: Local and landscape features promoting frog species richness in farm dams
Conserving nature's chorus: Local and landscape features promoting frog species richness in farm dams Open
Habitat loss is a key factor in the ongoing freshwater biodiversity crisis. A promising way to help tackle the rapid decline in freshwater biodiversity is to improve the potential for artificial wetlands to provide habitat for aquatic wild…
View article: Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity in Drosophila
Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity in Drosophila Open
Circadian clocks may mediate lifespan extension by caloric or dietary restriction (DR). We find that the core clock transcription factor Clock is crucial for a robust longevity and fecundity response to DR in Drosophila. To identify clock-…
View article: Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity in Drosophila
Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity in Drosophila Open
Circadian clocks may mediate lifespan extension by caloric or dietary restriction (DR). We find that the core clock transcription factor Clock is crucial for a robust longevity and fecundity response to DR in Drosophila. To identify clock-…
View article: Data from Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species
Data from Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species Open
Evidence has emerged that bone marrow cells have a greater degree of plasticity than previously thought. However, there has been a call to establish proof that these bone marrow–derived cells function appropriately in their new environment…
View article: Supplementary Figure 1 from Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species
Supplementary Figure 1 from Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species Open
Supplementary Figure 1 from Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species
View article: Supplementary Materials from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission <i>In vivo</i>
Supplementary Materials from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission <i>In vivo</i> Open
Supplementary Materials from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo
View article: Data from Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species
Data from Bone Marrow–Derived Stromal Cells Express Lineage-Related Messenger RNA Species Open
Evidence has emerged that bone marrow cells have a greater degree of plasticity than previously thought. However, there has been a call to establish proof that these bone marrow–derived cells function appropriately in their new environment…
View article: Supplementary Figure 1 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission <i>In vivo</i>
Supplementary Figure 1 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission <i>In vivo</i> Open
Supplementary Figure 1 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo
View article: Supplementary Methods, Figures 1-4 from Breast Cancer Dormancy Can Be Maintained by Small Numbers of Micrometastases
Supplementary Methods, Figures 1-4 from Breast Cancer Dormancy Can Be Maintained by Small Numbers of Micrometastases Open
Supplementary Methods, Figures 1-4 from Breast Cancer Dormancy Can Be Maintained by Small Numbers of Micrometastases
View article: Data from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission <i>In vivo</i>
Data from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission <i>In vivo</i> Open
P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be expressed in all inflamed, hyperplastic, and dysplastic intestinal and colonic muc…
View article: Supplementary Figure 1 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission <i>In vivo</i>
Supplementary Figure 1 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission <i>In vivo</i> Open
Supplementary Figure 1 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo
View article: Enhancing frog species richness at continental scales through farm dam management
Enhancing frog species richness at continental scales through farm dam management Open
Artificial waterbodies can help tackle the ongoing freshwater biodiversity crisis by providing new habitat for aquatic wildlife. Farm dams are among the most abundant artificial waterbodies in agricultural landscapes, yet general guideline…