Nichole E. LaPointe
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View article: Tau isoform–specific stabilization of intermediate states during microtubule assembly and disassembly
Tau isoform–specific stabilization of intermediate states during microtubule assembly and disassembly Open
The microtubule (MT)-associated protein tau regulates the critical growing and shortening behaviors of MTs, and its normal activity is essential for neuronal development and maintenance. Accordingly, aberrant tau action is tightly associat…
View article: 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose binds to the N-terminal metal binding region to inhibit amyloid β-protein oligomer and fibril formation
1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose binds to the N-terminal metal binding region to inhibit amyloid β-protein oligomer and fibril formation Open
View article: Oligomerization of the microtubule‐associated protein tau is mediated by its N‐terminal sequences: implications for normal and pathological tau action
Oligomerization of the microtubule‐associated protein tau is mediated by its N‐terminal sequences: implications for normal and pathological tau action Open
Despite extensive structure‐function analyses, the molecular mechanisms of normal and pathological tau action remain poorly understood. How does the C‐terminal microtubule‐binding region regulate microtubule dynamics and bundling? In what …
View article: Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels
Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels Open
In order to evaluate potential therapeutic targets for treatment of amyloidoses such as Alzheimer's disease (AD), it is essential to determine the structures of toxic amyloid oligomers. However, for the amyloid β-protein peptide (Aβ), thou…
View article: Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-Penta-<i>O</i>-galloyl-β-<scp>d</scp>-glucopyranose on Amyloid β<sub>25–35</sub> Assembly
Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-Penta-<i>O</i>-galloyl-β-<span>d</span>-glucopyranose on Amyloid β<sub>25–35</sub> Assembly Open
Alzheimer's disease (AD) is a neurodegenerative disease characterized by extracellular deposits of amyloid β protein (Aβ) in the brain. The conversion of soluble monomers to amyloid Aβ fibrils is a complicated process and involves several …
View article: Tau Aggregation Propensity Engrained in Its Solution State
Tau Aggregation Propensity Engrained in Its Solution State Open
A peptide fragment of the human tau protein which stacks to form neat cross β-sheet fibrils, resembling that found in pathological aggregation, (273)GKVQIINKKLDL(284) (here "R2/WT"), was modified with a spin-label at the N-terminus. With t…
View article: Regulation and aggregation of intrinsically disordered peptides
Regulation and aggregation of intrinsically disordered peptides Open
Significance The microtubule-regulating protein tau is a prototypical intrinsically disordered protein (IDP) that plays an important physiological role in the human body; however, aggregates of tau are a pathological hallmark of Alzheimer’…