Nick Curzen
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View article: Cost-Utility Analysis of TAVI Versus Surgery in Low-Risk Patients with Severe Aortic Stenosis in the UK
Cost-Utility Analysis of TAVI Versus Surgery in Low-Risk Patients with Severe Aortic Stenosis in the UK Open
Transcatheter aortic valve implantation with SAPIEN 3 has a 63-90% probability of being cost effective compared with SAVR for low-surgical-risk patients with sSAS. These findings may inform policy decision making in the management of this …
View article: Anatomical, physiological and inflammatory characterization of nonculprit vessels in patients undergoing primary PCI for ST-elevation myocardial infarction in the presence of multivessel disease: Rationale and design of the PICNIC study
Anatomical, physiological and inflammatory characterization of nonculprit vessels in patients undergoing primary PCI for ST-elevation myocardial infarction in the presence of multivessel disease: Rationale and design of the PICNIC study Open
PICNIC will characterize the anatomical, physiological, and inflammatory features of NIRA lesions in STEMI patients treated with culprit-only PCI in order to develop an AI-based risk prediction model. If such a model is successful it could…
View article: Expedited transfer to emergency department vs. cardiac catheter laboratory in a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest: ARREST trial as-treated analysis
Expedited transfer to emergency department vs. cardiac catheter laboratory in a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest: ARREST trial as-treated analysis Open
Aims The ARREST trial demonstrated that in adult patients, transfer to a cardiac catheter laboratory in a cardiac arrest centre (CAC) following resuscitated out-of-hospital cardiac arrest (OHCA) without ST-elevation did not reduce deaths a…
View article: Comparison of computed tomography coronary angiography (CTCA) alone vs. CTCA with selective FFRCT in patients presenting with stable chest pain: a FORECAST trial substudy
Comparison of computed tomography coronary angiography (CTCA) alone vs. CTCA with selective FFRCT in patients presenting with stable chest pain: a FORECAST trial substudy Open
Aims The original FORECAST trial was designed to compare a strategy of computed tomography coronary angiography (CTCA) and selective FFRCT to standard care in patients attending Rapid Access Chest Pain clinics in UK centres. This is a pres…
View article: 6-007 Quantifying the impact of heart valve surgery on time trends in echocardiographic sizes of the cardiac chambers using artificial intelligence
6-007 Quantifying the impact of heart valve surgery on time trends in echocardiographic sizes of the cardiac chambers using artificial intelligence Open
View article: 6-008 Sex-stratified analysis of the Functional FFRCT Score distribution and prognostic value in the FORECAST cohort
6-008 Sex-stratified analysis of the Functional FFRCT Score distribution and prognostic value in the FORECAST cohort Open
View article: Randomized Comparison of Fractional Flow Reserve and Instantaneous Wave Free Ratio in Serial Disease
Randomized Comparison of Fractional Flow Reserve and Instantaneous Wave Free Ratio in Serial Disease Open
FFR and iFR pullback gradients overestimate the benefit of target lesion PCI and can miss residual ischemia in one-third of patients. FFR or iFR should be routinely repeated post-PCI in serial disease.
View article: Design and rationale of “a pragmatic approach to the investigation of stable chest pain: A UK, multicenter, randomized trial to assess patient outcomes, quality of life and cost effectiveness (CE-MARC 3)”
Design and rationale of “a pragmatic approach to the investigation of stable chest pain: A UK, multicenter, randomized trial to assess patient outcomes, quality of life and cost effectiveness (CE-MARC 3)” Open
View article: SMART-ALERT study: continuous cardiac monitoring and real-time automated smartphone alerts for atrial fibrillation episodes
SMART-ALERT study: continuous cardiac monitoring and real-time automated smartphone alerts for atrial fibrillation episodes Open
Introduction 'Pill-in-the-pocket' oral anticoagulation (OAC) strategy is based on the concept that thromboembolic risk fluctuates—rising during and shortly after an atrial fibrillation (AF) episode and normalizing in sinus rhythm. Limiting…
View article: Diagnostic performance of single-lead electrocardiograms from a smartwatch and a smartring for cardiac arrhythmia detection
Diagnostic performance of single-lead electrocardiograms from a smartwatch and a smartring for cardiac arrhythmia detection Open
Apple Watch missed approximately 1 in 3 episodes of AF and a high number of unclassified SL-ECG. CART Ring demonstrated superior performance. Physician interpretation significantly improved AF diagnosis but remained unreliable for other ar…
View article: The International Trifecta<sup>TM</sup> and Epic<sup>TM</sup> Valve‐in‐Valve Registry: Insights Into Clinical & Hemodynamic Outcomes
The International Trifecta<sup>TM</sup> and Epic<sup>TM</sup> Valve‐in‐Valve Registry: Insights Into Clinical & Hemodynamic Outcomes Open
Background Little is known about the clinical and hemodynamic outcome of valve‐in‐valve transcatheter aortic valve replacement (ViV‐TAVR) for failed Trifecta surgical aortic bioprotheses. Aims We aimed to compare outcomes of valve‐in‐valve…
View article: Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy
Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy Open
Background The impact of sex‐related differences in coronary atheroma and flow impairment severity on clinical events and costs remains unclear. Methods and Results This is a secondary analysis of patients with stable coronary artery disea…
View article: Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial
Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial Open
BACKGROUND: The PRECISE (Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization) demonstrated that a precision diagnostic strategy reduced the primary composite of death, nonfatal myocardial infarc…
View article: Percutaneous Coronary Intervention in the UK: Recommendations of the British Cardiovascular Intervention Society
Percutaneous Coronary Intervention in the UK: Recommendations of the British Cardiovascular Intervention Society Open
Percutaneous techniques to treat obstructive coronary artery disease continue to evolve and the evidence base informing our practice is shared and summarised in international guidelines. In the UK, the British Cardiovascular Intervention S…
View article: Development of a methodology for in vitro and in silico simulation of transcatheter aortic valve replacement using 3D-printed valve frames
Development of a methodology for in vitro and in silico simulation of transcatheter aortic valve replacement using 3D-printed valve frames Open
Manufacture of a SAPIEN S3 type heart valve frame using LPBF has been shown to provide a viable procedure for producing frames for testing and assessment when crimped and deployed into a model of an aortic root. Further, the validated in s…
View article: A pragmatic approach to the investigation of stable chest pain: A UK, multi-centre, randomised trial to improve patient outcomes, quality of life and cost effectiveness (CE-MARC 3)
A pragmatic approach to the investigation of stable chest pain: A UK, multi-centre, randomised trial to improve patient outcomes, quality of life and cost effectiveness (CE-MARC 3) Open
View article: BRITISH, an ongoing randomised trial of implantable defibrillators for non-ischemic cardiomyopathy with severe LV impairment and myocardial scar: trial design and update.
BRITISH, an ongoing randomised trial of implantable defibrillators for non-ischemic cardiomyopathy with severe LV impairment and myocardial scar: trial design and update. Open
View article: British Cardiovascular Intervention Society Training Culture Focus Group Position Statement: Bringing Trainees and Trainers Together
British Cardiovascular Intervention Society Training Culture Focus Group Position Statement: Bringing Trainees and Trainers Together Open
Unprofessional behaviour within cardiology has been well documented and commonly occurs within the cardiac catheterisation laboratory, with higher rates in interventional subspecialities. While most trainees have positive experiences and e…
View article: Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Coronary Artery Disease
Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Coronary Artery Disease Open
BACKGROUND: ORBITA-2 (the Placebo-Controlled Trial of Percutaneous Coronary Intervention for the Relief of Stable Angina) provided evidence for the role of percutaneous coronary intervention (PCI) for angina relief in stable coronary arter…
View article: Temporal trend and regional disparity in the investigations for stable chest pain in Europe: An insight from the PIONEER IV trial
Temporal trend and regional disparity in the investigations for stable chest pain in Europe: An insight from the PIONEER IV trial Open
View article: DROPLET MICROFLUIDICS FOR DETECTING HYPER-REACTIVE PLATELETS
DROPLET MICROFLUIDICS FOR DETECTING HYPER-REACTIVE PLATELETS Open
Introduction: Cardiovascular Diseases (CVDs) are the main cause of morbidity and mortality globally. Of these, elevated platelet reactivity is a common cause of heart attacks and strokes. Platelet function assay typically measures platelet…
View article: Safety and performance of the ultrathin sirolimus-eluting coronary stent in an all-comer patient population: the S-FLEX UK-II registry
Safety and performance of the ultrathin sirolimus-eluting coronary stent in an all-comer patient population: the S-FLEX UK-II registry Open
Objective We evaluated the clinical safety and performance of the ultrathin strut biodegradable polymer-coated Supraflex Cruz (Sahajanand Medical TechnologiesLtd., Surat, India) sirolimus-eluting stent (SES) in an all-comer patient populat…
View article: Association between kidney function, frailty and receipt of invasive management after acute coronary syndrome
Association between kidney function, frailty and receipt of invasive management after acute coronary syndrome Open
Background Reduced estimated glomerular filtration rate (eGFR) is associated with lower use of invasive management and increased mortality after acute coronary syndrome (ACS). The reasons for this are unclear. Methods A retrospective clini…
View article: In‐hospital outcomes of ad hoc versus planned PCI for unprotected left‐main disease: An analysis of 8574 cases from British Cardiovascular Intervention Society database 2006–2018
In‐hospital outcomes of ad hoc versus planned PCI for unprotected left‐main disease: An analysis of 8574 cases from British Cardiovascular Intervention Society database 2006–2018 Open
Background Although data suggests ad hoc percutaneous coronary intervention (PCI) results in similar patient outcomes compared to planned PCI in nonselected patients, data for ad hoc unprotected left main stem PCI (uLMS‐PCI) are lacking. A…
View article: “Real‐world” performance of the Confirm Rx™ <scp>SharpSense AF</scp> detection algorithm: <scp>UK</scp> Confirm Rx study
“Real‐world” performance of the Confirm Rx™ <span>SharpSense AF</span> detection algorithm: <span>UK</span> Confirm Rx study Open
Introduction The novel Confirm Rx™ implantable cardiac monitor (ICM) with SharpSense™ technology incorporates a new P‐wave discriminator designed to improve AF detection. This study aimed to evaluate the diagnostic performance of the Confi…
View article: Geographical Inequality in Access to Aortic Valve Intervention in England: A Report from the UK Transcatheter Aortic Valve Implantation Registry and National Adult Cardiac Surgery Audit
Geographical Inequality in Access to Aortic Valve Intervention in England: A Report from the UK Transcatheter Aortic Valve Implantation Registry and National Adult Cardiac Surgery Audit Open
Background: For patients with severe aortic stenosis, transcatheter aortic valve implantation (TAVI) is a less invasive but equally effective treatment option compared with surgical aortic valve replacement (SAVR). In 2019, we reported low…
View article: Does one size really fit all? The case for personalized antiplatelet therapy in interventional cardiology
Does one size really fit all? The case for personalized antiplatelet therapy in interventional cardiology Open
Cardiovascular disease is the leading cause of death worldwide. Dual antiplatelet therapy (DAPT), with aspirin plus a P2Y12 inhibitor, is currently recommended as a default for patients after acute coronary syndrome (ACS) and following per…
View article: D Leveraging machine learning for rapid rule-out of acute coronary syndromes
D Leveraging machine learning for rapid rule-out of acute coronary syndromes Open
Background Current Acute Coronary Syndromes (ACS) rule-out algorithms rely on a combination of clinical assessment and measuring troponin levels. It can take several hours for troponin levels to rise after a myocardial infarction, so initi…
View article: Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data
Changes in the investigation and management of suspected myocardial infarction and injury during COVID-19: a multi-centre study using routinely collected healthcare data Open
Objective The COVID-19 pandemic was associated with a reduction in the incidence of myocardial infarction (MI) diagnosis, in part because patients were less likely to present to hospital. Whether changes in clinical decision making with re…
View article: Impact of Society Guidelines on Trends in Use of Newer P2Y <sub>12</sub> Inhibitors for Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention
Impact of Society Guidelines on Trends in Use of Newer P2Y <sub>12</sub> Inhibitors for Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Open
Background Over the past decade, major society guidelines have recommended the use of newer P2Y 12 inhibitors over clopidogrel for those undergoing percutaneous coronary intervention for acute coronary syndrome. It is unclear what impact t…