Nick H.T. ten Hacken
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View article: Airway smooth muscle and long-term clinical efficacy following bronchial thermoplasty in severe asthma
Airway smooth muscle and long-term clinical efficacy following bronchial thermoplasty in severe asthma Open
The mechanism of action of bronchial thermoplasty (BT) treatment for patients with severe asthma is incompletely understood. This study investigated the 2.5-year impact of BT on airway smooth muscle (ASM) mass and clinical parameters by pa…
View article: Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls
Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls Open
Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results in…
View article: Airway Inflammation Before and After Bronchial Thermoplasty in Severe Asthma
Airway Inflammation Before and After Bronchial Thermoplasty in Severe Asthma Open
Local differences in gene sets pertaining to epithelial inflammatory status were identified between treated and untreated airways after treatment, not resulting in changes in differential cell counts and cytokine analyses in BALF. Secondly…
View article: Smoking induces shifts in cellular composition and transcriptome within the bronchial mucus barrier
Smoking induces shifts in cellular composition and transcriptome within the bronchial mucus barrier Open
Background and Objective Smoking disturbs the bronchial‐mucus‐barrier. This study assesses the cellular composition and gene expression shifts of the bronchial‐mucus‐barrier with smoking to understand the mechanism of mucosal damage by cig…
View article: Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls
Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls Open
Background : Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results …
View article: Long-term follow-up after bronchoscopic lung volume reduction valve treatment for emphysema
Long-term follow-up after bronchoscopic lung volume reduction valve treatment for emphysema Open
Background Multiple studies have shown that patients with severe emphysema can significantly benefit from bronchoscopic lung volume reduction endobronchial valve (EBV) treatment up to 1 year after treatment. However, hardly any data exist …
View article: Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans
Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans Open
Background There is a strong need for biomarkers to better characterize individuals with COPD and to take into account the heterogeneity of COPD. The blood protein sRAGE has been put forward as promising biomarker for COPD in general and e…
View article: Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways
Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways Open
Funder: Dutch Research Council (NWO)
View article: Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells
Paracrine Regulation of Alveolar Epithelial Damage and Repair Responses by Human Lung-Resident Mesenchymal Stromal Cells Open
COPD is characterized by irreversible lung tissue damage. We hypothesized that lung-derived mesenchymal stromal cells (LMSCs) reduce alveolar epithelial damage via paracrine processes, and may thus be suitable for cell-based strategies in …
View article: Adsorptive Microtiter Plates As Solid Supports in Affinity Purification Workflows
Adsorptive Microtiter Plates As Solid Supports in Affinity Purification Workflows Open
Affinity ligands such as antibodies are widely used in (bio)medical research for purifying proteins from complex biological samples. These ligands are generally immobilized onto solid supports which facilitate the separation of a captured …
View article: Bronchoscopic Targeted Lung Denervation in Patients with Severe Asthma: Preliminary Findings
Bronchoscopic Targeted Lung Denervation in Patients with Severe Asthma: Preliminary Findings Open
Treatment options for severe asthma are limited, particularly in those patients who do not meet criteria for biologicals. Targeted lung denervation (TLD) is the bronchoscopic ablation of the peribronchial vagal nerve trunks to reduce choli…
View article: Neutrophilic Asthma Is Associated With Smoking, High Numbers of IRF5+, and Low Numbers of IL10+ Macrophages
Neutrophilic Asthma Is Associated With Smoking, High Numbers of IRF5+, and Low Numbers of IL10+ Macrophages Open
Asthma is a heterogenous disease with different inflammatory subgroups that differ in disease severity. This disease variation is hampering treatment and development of new treatment strategies. Macrophages may contribute to asthma phenoty…
View article: Single-nucleotide polymorphism rs2070600 regulates<i>AGER</i>splicing and the sputum levels of the COPD biomarker soluble receptor for advanced glycation end-products
Single-nucleotide polymorphism rs2070600 regulates<i>AGER</i>splicing and the sputum levels of the COPD biomarker soluble receptor for advanced glycation end-products Open
The COPD susceptibility SNP rs2070600 affects the levels of the COPD biomarker sRAGE in sputum as well as splicing of AGER. Moreover, @PouwelsScience et al. demonstrate large differences in sRAGE levels between serum and sputum. https://bi…
View article: Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema
Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema Open
Mesenchymal stromal cells (MSCs) may provide crucial support in the regeneration of destructed alveolar tissue (emphysema) in chronic obstructive pulmonary disease (COPD). We hypothesized that lung-derived MSCs (LMSCs) from patients with e…
View article: Comparison of multiple diagnostic tests to measure dynamic hyperinflation in patients with severe emphysema treated with endobronchial coils
Comparison of multiple diagnostic tests to measure dynamic hyperinflation in patients with severe emphysema treated with endobronchial coils Open
Purpose For this study we aimed to compare dynamic hyperinflation measured by cardiopulmonary exercise testing (CPET), a six-minute walking test (6MWT) and a manually paced tachypnea test (MPT) in patients with severe emphysema who were tr…
View article: Metabolic differences between bronchial epithelium from healthy individuals and patients with asthma and the effect of bronchial thermoplasty
Metabolic differences between bronchial epithelium from healthy individuals and patients with asthma and the effect of bronchial thermoplasty Open
BECs in patients with asthma are metabolically different from those in healthy individuals. These differences are linked with inflammation and asthma severity, and they can be reversed by bronchial thermoplasty.
View article: Identifying Responders and Exploring Mechanisms of Action of the Endobronchial Coil Treatment for Emphysema
Identifying Responders and Exploring Mechanisms of Action of the Endobronchial Coil Treatment for Emphysema Open
Background: So far, 3 randomized controlled trials have shown that the endobronchial treatment using coils is safe and effective. However, the more exact underlying mechanism of the treatment and best predictors of response are unknown. Ob…
View article: Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Biomarker of COPD&nbsp;
Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Biomarker of COPD Open
Background:Soluble receptor for advanced glycation end products (sRAGE) is a proposed emphysema and airflow obstruction biomarker; however, previous publication have shown inconsistent associations and only one study has investigate the as…
View article: The effects of lung volume reduction treatment on diffusing capacity and gas exchange
The effects of lung volume reduction treatment on diffusing capacity and gas exchange Open
Lung volume reduction (LVR) treatment in patients with severe emphysema has been shown to have a positive effect on hyperinflation, expiratory flow, exercise capacity and quality of life. However, the effects on diffusing capacity of the l…
View article: Acute cigarette smoke‐induced <scp>eQTL</scp> affects formyl peptide receptor expression and lung function
Acute cigarette smoke‐induced <span>eQTL</span> affects formyl peptide receptor expression and lung function Open
Background and objective Cigarette smoking is one of the most prevalent causes of preventable deaths worldwide, leading to chronic diseases, including chronic obstructive pulmonary disease (COPD). Cigarette smoke is known to induce signifi…
View article: Predicted values for the forced expiratory flow adjusted for forced vital capacity, a descriptive study
Predicted values for the forced expiratory flow adjusted for forced vital capacity, a descriptive study Open
Background The forced expiratory flows (FEFs) towards the end of the expiration may be more sensitive in detecting peripheral airways obstruction compared to the forced expiratory volume in 1 s and forced vital capacity (FVC). However, the…
View article: Gene signatures from scRNA‐seq accurately quantify mast cells in biopsies in asthma
Gene signatures from scRNA‐seq accurately quantify mast cells in biopsies in asthma Open
Respiratory disease, characterized by changes in the cells of the lung, can affect molecular phenotype of cells and the intercellular interactions, resulting in a disbalance in the relative proportions of individual cell types. Understandi…
View article: Patient Satisfaction and Attainment of Patient-Specific Goals after Endobronchial Valve Treatment
Patient Satisfaction and Attainment of Patient-Specific Goals after Endobronchial Valve Treatment Open
Rationale: Bronchoscopic lung volume reduction with endobronchial valves (EBVs) significantly improves clinical outcomes in patients with severe emphysema. However, patient-reported outcomes like patient satisfaction and patient-specific t…
View article: Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways
Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways Open
Background The recent outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has led to a worldwide pandemic. A subset of COVID-19 patients progresses to severe disea…
View article: Endobronchial valve therapy for severe emphysema: an overview of valve-related complications and its management
Endobronchial valve therapy for severe emphysema: an overview of valve-related complications and its management Open
Treating severe emphysema patients with one-way valves requires continuous dedication and expertise, especially to achieve an optimal outcome and elegantly deal with the various complications after treatment.
View article: Bronchial Thermoplasty Induced Airway Smooth Muscle Reduction and Clinical Response in Severe Asthma. The TASMA Randomized Trial
Bronchial Thermoplasty Induced Airway Smooth Muscle Reduction and Clinical Response in Severe Asthma. The TASMA Randomized Trial Open
Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction after BT, but appropriate control groups are lacking. Furthermo…