Nick Meader
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View article: Motivational effectiveness of prosocial public health messaging to reduce respiratory infection risk: a systematic review and meta-analysis
Motivational effectiveness of prosocial public health messaging to reduce respiratory infection risk: a systematic review and meta-analysis Open
Background Clear communication is essential for the effective uptake of public health interventions promoting protective behaviours for respiratory infection control. The emergence of novel infectious diseases, particularly the COVID-19 pa…
View article: A systematic review and meta-analysis to identify behavioural content and active ingredients of antimicrobial stewardship education and training interventions in hospital-based care settings
A systematic review and meta-analysis to identify behavioural content and active ingredients of antimicrobial stewardship education and training interventions in hospital-based care settings Open
Background The growing threat of antimicrobial resistance has led to efforts to improve the responsible use of antimicrobials (antimicrobial stewardship - AMS). AMS education and training is essential for providing healthcare professionals…
View article: International comparison of medicines approvals in the UK: a retrospective analysis
International comparison of medicines approvals in the UK: a retrospective analysis Open
Objectives To understand the regulatory landscape in the UK and globally before the introduction of the Medicines and Healthcare Products Regulatory Agency’s (MHRA) International Recognition Procedure (IRP). This paper aims to inform on th…
View article: Algorithm-based remote monitoring of heart failure risk data in people with cardiac implantable electronic devices: a systematic review and cost-effectiveness analysis
Algorithm-based remote monitoring of heart failure risk data in people with cardiac implantable electronic devices: a systematic review and cost-effectiveness analysis Open
Background Heart failure is a clinical syndrome caused by any structural or functional cardiac disorder that impairs the heart’s ability to function efficiently and pump blood around the body. Function can also be monitored using cardiac i…
View article: Systematic Review: The Relationship Between the Faecal Microbiome and Colorectal Neoplasia in Shotgun Metagenomic Studies
Systematic Review: The Relationship Between the Faecal Microbiome and Colorectal Neoplasia in Shotgun Metagenomic Studies Open
Background The human gut microbiome is of academic and clinical interest. Associations between certain organisms and colorectal neoplasia have been reported, but findings have limited reproducibility in different populations. Methods We pe…
View article: Innovative technologies for asthma and COPD management in the community: scanning the horizon using rapid systematic review methods
Innovative technologies for asthma and COPD management in the community: scanning the horizon using rapid systematic review methods Open
Introduction This rapid systematic review and horizon scan aimed to identify technologies available or in development to support the monitoring and self-management of asthma and/or chronic obstructive pulmonary disease (COPD) outside tradi…
View article: Interventions for helping people recognise early signs of recurrence in bipolar disorder
Interventions for helping people recognise early signs of recurrence in bipolar disorder Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the effectiveness of EWS plus TAU or EWS plus psychological therapy versus TAU alone or psychological treatment (without EWS) independently…
View article: Methods used in early value assessments for nice: a scoping review
Methods used in early value assessments for nice: a scoping review Open
Objectives The National Institute for Health and Care Excellence (NICE) in England introduced early value assessments (EVAs) as an evidence-based method of accelerating access to promising health technologies that could address unmet needs…
View article: Motivational effectiveness of prosocial public health messaging to reduce respiratory infection risk: A network meta-analysis
Motivational effectiveness of prosocial public health messaging to reduce respiratory infection risk: A network meta-analysis Open
Clear communication is vital for adopting public health interventions that promote protective behaviours against respiratory infections. This systematic review and network meta-analysis assessed the effectiveness of these interventions usi…
View article: Development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data from multiple studies
Development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data from multiple studies Open
Background Relapse of depression is common and contributes to the overall associated morbidity and burden. We lack evidence-based tools to estimate an individual’s risk of relapse after treatment in primary care, which may help us more eff…
View article: Genedrive kit for detecting single nucleotide polymorphism m.1555A>G in neonates and their mothers: a systematic review and cost-effectiveness analysis
Genedrive kit for detecting single nucleotide polymorphism m.1555A>G in neonates and their mothers: a systematic review and cost-effectiveness analysis Open
Background Neonates with suspected sepsis are commonly treated with gentamicin, an aminoglycoside. These antibiotics are associated with high risk of ototoxicity, including profound bilateral deafness, in people with the m.1555A>G mitochon…
View article: Devices for remote continuous monitoring of people with Parkinson’s disease: a systematic review and cost-effectiveness analysis
Devices for remote continuous monitoring of people with Parkinson’s disease: a systematic review and cost-effectiveness analysis Open
Background Parkinson’s disease is a brain condition causing a progressive loss of co ordination and movement problems. Around 145,500 people have Parkinson’s disease in the United Kingdom. Levodopa is the most prescribed treatment for mana…
View article: The development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data from multiple studies
The development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data from multiple studies Open
Background Relapse of depression is common and contributes to the overall associated morbidity and burden. We lack evidence-based tools to estimate an individual’s risk of relapse after treatment in primary care, which may help us more eff…
View article: Early pharmacological interventions for prevention of post-traumatic stress disorder (PTSD) in individuals experiencing acute traumatic stress symptoms
Early pharmacological interventions for prevention of post-traumatic stress disorder (PTSD) in individuals experiencing acute traumatic stress symptoms Open
This review provides uncertain evidence regarding the use of escitalopram, hydrocortisone, intranasal oxytocin and temazepam for people with acute stress symptoms. It is therefore unclear whether these pharmacological interventions exert a…
View article: New or repurposed: a novel classification system for the horizon scanning of innovative medicines
New or repurposed: a novel classification system for the horizon scanning of innovative medicines Open
Objectives It is vital that horizon scanning organizations can capture and disseminate intelligence on new and repurposed medicines in clinical development. To our knowledge, there are no standardized classification systems to capture this…
View article: Automated data analysis of unstructured grey literature in health research: A mapping review
Automated data analysis of unstructured grey literature in health research: A mapping review Open
The amount of grey literature and ‘softer’ intelligence from social media or websites is vast. Given the long lead‐times of producing high‐quality peer‐reviewed health information, this is causing a demand for new ways to provide prompt in…
View article: Pharmacological treatments in panic disorder in adults: a network meta-analysis
Pharmacological treatments in panic disorder in adults: a network meta-analysis Open
In terms of efficacy, SSRIs, SNRIs (venlafaxine), TCAs, MAOIs and BDZs may be effective, with little difference between classes. However, it is important to note that the reliability of these findings may be limited due to the overall low …
View article: Predicting and preventing relapse of depression in primary care: a mixed methods study
Predicting and preventing relapse of depression in primary care: a mixed methods study Open
CONTEXT: Relapse (re-emergence of depression symptoms) is common after depression. We lack evidence-based approaches for identifying people at higher risk of relapse. It is uncertain how widely, and in what form, relapse prevention strateg…
View article: Mental Health First Aid as a tool for improving mental health and well-being
Mental Health First Aid as a tool for improving mental health and well-being Open
We cannot draw conclusions about the effects of MHFA training on our primary outcomes due to the lack of good quality evidence. This is the case whether it is compared to no intervention, to an alternative mental health literacy interventi…
View article: Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants
Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants Open
Given the low to moderate certainty of evidence for the effects of probiotic supplements on the risk of NEC and associated morbidity and mortality for very preterm or VLBW infants, and particularly for extremely preterm or ELBW infants, th…
View article: Automated data extraction of unstructured grey literature in health research: a mapping review of the current research literature
Automated data extraction of unstructured grey literature in health research: a mapping review of the current research literature Open
The amount of grey literature and ‘softer’ intelligence from social media or websites is vast. Given the long lead-times of producing high-quality peer-reviewed health information this is causing a demand for new ways to provide prompt inp…
View article: The association between maternal and paternal substance use and child substance use, internalizing and externalizing problems: a systematic review and meta‐analysis
The association between maternal and paternal substance use and child substance use, internalizing and externalizing problems: a systematic review and meta‐analysis Open
Aims There is substantial evidence showing an association between parental substance use and child substance use and/or mental health problems. Most research focuses upon maternal substance use, with the influence of paternal substance use…
View article: Can we mitigate the psychological impacts of social isolation using behavioural activation? Long-term results of the UK BASIL urgent public health COVID-19 pilot randomised controlled trial and living systematic review
Can we mitigate the psychological impacts of social isolation using behavioural activation? Long-term results of the UK BASIL urgent public health COVID-19 pilot randomised controlled trial and living systematic review Open
Background Behavioural and cognitive interventions remain credible approaches in addressing loneliness and depression. There was a need to rapidly generate and assimilate trial-based data during COVID-19. Objectives We undertook a parallel…
View article: Can we mitigate the psychological impacts of social isolation using behavioural activation? Long-term results of the UK BASIL Urgent Public Health COVID-19 pilot randomised controlled trial and living systematic review
Can we mitigate the psychological impacts of social isolation using behavioural activation? Long-term results of the UK BASIL Urgent Public Health COVID-19 pilot randomised controlled trial and living systematic review Open
Background Behavioural and cognitive interventions remain a credible approach in preventing loneliness and depression. There was a need to rapidly generate and assimilate trial-based data during COVID-19. Objectives We undertook a COVID-19…
View article: Multiple versus single risk behaviour interventions for people with severe mental illness: a network meta-analysis and qualitative synthesis
Multiple versus single risk behaviour interventions for people with severe mental illness: a network meta-analysis and qualitative synthesis Open
Background People with severe mental illness die 15–20 years earlier than the general population. Reasons why include that people with severe mental illness are more likely to smoke and be physically inactive as a result of social inequali…
View article: Interventions for preventing relapse or recurrence of major depressive disorder in adults in a primary care setting: a network meta-analysis
Interventions for preventing relapse or recurrence of major depressive disorder in adults in a primary care setting: a network meta-analysis Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: The aim is to assess, using network meta‐analysis (NMA), the effectiveness and safety of interventions for preventing relapse‐recurrence of depression …
View article: Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD)
Behavioural and cognitive behavioural therapy for obsessive compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD) Open
We included only one RCT of 46 participants in our analysis. This study compared CBT for OCD in persons with high-functioning ASD with a control group who received anxiety management only. There were no differences in rates of treatment co…