Explanipedia

Donor human milk and structural brain development in very preterm infants Open

Katherine M. Ottolini, Sudeepta K. Basu, Julius S. Ngwa, Kushal Kapse, Jonathan Murnick , et al. · 2025

Background We investigated the impact of donor milk on structural brain development, relative to maternal milk feeding, in very preterm infants at term-equivalent age (TEA). Methods Very preterm infants ( ≤32 weeks’ gestation) were enrolle…

Brain metabolite concentrations in neonates with congenital heart disease before and after cardiac surgery Open

Steve C. N. Hui, Nickie Andescavage, Julius S. Ngwa, Kushal Kapse, Jonathan Murnick , et al. · 2025

Measures of Brain Metabolism and Diffusion in Neonates of Diabetic Mothers Open

Steve C. N. Hui, Nahla M.H. Elsaid, Julius S. Ngwa, Kushal Kapse, Catherine Limperopoulos , et al. · 2025

AD = axial diffusivity; DM = Diabetes mellitus; FA = fractional anisotropy; GA = gestational age; IDMs = infants of diabetic mothers; MD = mean diffusivity; PMA = postmenstrual age; RD = radial diffusivity; SNR = signal-to-noise ratio; STR…

Epigenomic signatures of accelerated epigenetic aging are associated with congenital heart disease in newborns Open

Kristen Kocher, Julius S. Ngwa, Surajit Bhattacharya, Mary T. Donofrio, Catherine Limperopoulos , et al. · 2025

MATERNAL MOOD OUTCOMES DURING PREGNANCY AND POSTPARTUM FOLLOWING ASSISTED REPRODUCTIVE TECHNOLOGY COMPARED TO NATURAL CONCEPTION Open

Chinormso Diribe, Nickie Andescavage, Catherine Limperopoulos · 2025

Objective: Psychological distress (PD), anxiety, and depression are common in pregnancy and have significant implications for maternal and fetal well-being. The association between assisted reproductive technology (ART) and perinatal mood …

Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants Open

Sudeepta K. Basu, Katherine M. Ottolini, Kushal Kapse, Julius S. Ngwa, Steve C. N. Hui , et al. · 2025

Parenteral lipid intake is associated with higher cerebellar NAA and Glx concentrations, supporting brain development in preterm infants.

Placental and Fetal In Utero Growth Among Fetuses With Congenital Heart Disease Open

Marin Jacobwitz, Kushal Kapse, Julius S. Ngwa, Josepheen De Asis‐Cruz, Yao Wu , et al. · 2025

Importance At birth, neonates with congenital heart disease (CHD) have smaller placentas, lower birth weight, and smaller head circumferences compared with healthy neonates. The onset of feto-placental growth disturbances, however, is not …

Protocol for a randomized controlled trial of the Mommy&Me study: A multi-modal approach to address social determinants of health and mental health among low-income Black perinatal populations Open

Huynh‐Nhu Le, Nickie Andescavage, Jennifer M. Keller, Maariya Bassa, Aimee Danielson , et al. · 2025

If found to be efficacious, results will help develop scalable, culturally relevant interventions aimed at reducing racial disparities in maternal mental health care and improving health outcomes for both mothers and infants. Trial registr…

Placental quantitative susceptibility mapping and T2* characteristics for predicting birth weight in healthy and high-risk pregnancies Open

Morteza Pishghadam, Lylach Haizler‐Cohen, Julius S. Ngwa, Yao Wu, Kushal Kapse , et al. · 2025

Background The human placenta is critical in supporting fetal development, and placental dysfunction may compromise maternal-fetal health. Early detection of placental dysfunction remains challenging due to the lack of reliable biomarkers.…

The Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research Open

Steve C. N. Hui, Nickie Andescavage, Catherine Limperopoulos · 2025

The biochemical composition and structure of the brain are in a rapid change during the exuberant stage of fetal and neonatal development. 1 H‐MRS is a noninvasive tool that can evaluate brain metabolites in healthy fetuses and infants as …

Altered brain state dynamics between preterm and term-born infants Open

Srikanth R. Damera, Sudeepta K. Basu, Kushal Kapse, Jon Murnick, Nickie Andescavage , et al. · 2025

Preterm birth alters the development of infant brain networks. However, most prior studies investigate its effects on static brain networks rather than dynamic brain states. Increasing evidence shows that brain state dynamics reflect cogni…

Protocol for a Randomized Controlled Trial of the Mommy&Me Study: A Multi-Modal Approach to Address Social Determinants of Health and Mental Health Among Low-Income Black Perinatal Populations Open

Huynh‐Nhu Le, Nickie Andescavage, Jennifer M. Keller, Maariya Bassa, Aimee Danielson , et al. · 2025

Brain development using a multicomponent intravenous lipid emulsion in preterm infants Open

Katherine M. Ottolini, Julius S. Ngwa, Sudeepta K. Basu, Kushal Kapse, Melissa Liggett , et al. · 2024

Technical considerations for placental tissue processing and the subsequent impact on genome-wide DNA methylation analysis Open

Kristen Kocher, Julius S. Ngwa, Kushal Kapse, Surajit Bhattacharya, Christopher Rossi , et al. · 2024

To assess the impact of postnatal processing on placental DNA methylation, array data from flash-frozen placental tissue was compared to perfluorocarbon-immersed and formalin-fixed paraffin-embedded placental tissue. We observed that tissu…

Single vs. multi-slice assessments of in vivo placental T2∗ measurements Open

Morteza Pishghadam, Julius S. Ngwa, Yao Wu, Kushal Kapse, Lylach Haizler‐Cohen , et al. · 2024

Prenatal Maternal Psychological Distress During the COVID-19 Pandemic and Newborn Brain Development Open

Susan Weiner, Yao Wu, Kushal Kapse, Tracy Moran Vozar, J. Cheng , et al. · 2024

Importance Elevated maternal psychological distress during pregnancy is associated with altered fetal brain development. During the COVID-19 pandemic, prenatal maternal psychological distress more than doubled. Objective To examine the ass…

Regional homogeneity as a marker of sensory cortex dysmaturity in preterm infants Open

Srikanth R. Damera, Josepheen De Asis‐Cruz, Kevin M. Cook, Kushal Kapse, Emma Spoehr , et al. · 2024

Atypical perinatal sensory experience in preterm infants is thought to increase their risk of neurodevelopmental disabilities by altering the development of the sensory cortices. Here, we used resting-state fMRI data from preterm and term-…

Central Autonomic Network and Heart Rate Variability in Premature Neonates Open

Kelsey Christoffel, Josepheen De Asis‐Cruz, Rathinaswamy B. Govindan, Jung Hoon Kim, Kevin M. Cook , et al. · 2024

Introduction: The Central Autonomic Network (CAN) is a hierarchy of brain structures that collectively influence cardiac autonomic input, mediating the majority of brain-heart interactions, but has never been studied in premature neonates.…

Intrauterine exposure to SARS-CoV-2 infection and early newborn brain development Open

Nickie Andescavage, Yuan-Chiao Lu, Yao Wu, Kushal Kapse, Jennifer M. Keller , et al. · 2024

Epidemiologic studies suggest that prenatal exposures to certain viruses may influence early neurodevelopment, predisposing offspring to neuropsychiatric conditions later in life. The long-term effects of maternal COVID-19 infection in pre…

Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits Open

Kevin M. Cook, Josepheen De Asis‐Cruz, Jung‐Hoon Kim, Sudeepta K. Basu, Nickie Andescavage , et al. · 2023

Background Infants born very and extremely premature (V/EPT) are at a significantly elevated risk for neurodevelopmental disorders and delays even in the absence of structural brain injuries. These risks may be due to earlier-than-typical …

Genome-wide neonatal epigenetic changes associated with maternal exposure to the COVID-19 pandemic Open

Kristen Kocher, Surajit Bhattacharya, Nickie Andescavage, Miguel Almalvez, Diedtra Henderson , et al. · 2023

Disrupted Functional Brain Connectome in the Fetus With Congenital Heart Disease Open

Josepheen De Asis‐Cruz, Nickie Andescavage, Mary T. Donofrio, Gilbert Vézina, David Wessel , et al. · 2023

Impact of bronchopulmonary dysplasia on brain GABA concentrations in preterm infants: Prospective cohort study Open

Sudeepta K. Basu, Kushal Kapse, Jonathan Murnick, Subechhya Pradhan, Emma Spoehr , et al. · 2023

Ex-utero third trimester developmental changes in functional brain network organization in infants born very and extremely preterm Open

Kevin M. Cook, Josepheen De Asis‐Cruz, Sudeepta K. Basu, Nickie Andescavage, Jonathan Murnick , et al. · 2023

Introduction The latter half of gestation is a period of rapid brain development, including the formation of fundamental functional brain network architecture. Unlike in-utero fetuses, infants born very and extremely preterm undergo these …

Examining the relationship between fetal cortical thickness, gestational age, and maternal psychological distress Open

Josepheen De Asis‐Cruz, Jung‐Hoon Kim, Dhineshvikram Krishnamurthy, Catherine Lopez, Kushal Kapse , et al. · 2023

Influence of maternal psychological distress during COVID-19 pandemic on placental morphometry and texture Open

Haleema Saeed, Yuan-Chiao Lu, Nickie Andescavage, Kushal Kapse, Nicole Andersen , et al. · 2023

The Coronavirus Disease 2019 (COVID-19) pandemic has been accompanied by increased prenatal maternal distress (PMD). PMD is associated with adverse pregnancy outcomes which may be mediated by the placenta. However, the potential impact of …

Severity of prematurity and age impact early postnatal development of GABA and glutamate systems Open

Sudeepta K. Basu, Subechhya Pradhan, Yushuf M Sharker, Kushal Kapse, Jonathan Murnick , et al. · 2023

Gamma-aminobutyric acid (GABA) and glutamatergic system perturbations following premature birth may explain neurodevelopmental deficits in the absence of structural brain injury. Using GABA-edited spectroscopy (MEscher-GArwood Point Resolv…

Impaired in vivo feto-placental development is associated with neonatal neurobehavioral outcomes Open

Nickie Andescavage, Theresa Bullen, Melissa Liggett, Scott D. Barnett, Anushree Kapse , et al. · 2022

Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain Open

Yuan-Chiao Lu, Nickie Andescavage, Yao Wu, Kushal Kapse, Nicole Andersen , et al. · 2022

Association of Elevated Maternal Psychological Distress, Altered Fetal Brain, and Offspring Cognitive and Social-Emotional Outcomes at 18 Months Open

Yao Wu, Kristina Espinosa, Scott D. Barnett, Anushree Kapse, Jessica Quistorff , et al. · 2022

In this cohort study of 97 mother-infant dyads, fetal cortical local gyrification index and sulcal depth were associated with infant 18-month social-emotional and competence outcomes, and fetal left hippocampal volume mediated the associat…

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