Nicklas Raun Jacobsen
YOU?
Author Swipe
View article: Biokinetics of inhaled silver, gold, copper oxide, and zinc oxide nanoparticles: a review
Biokinetics of inhaled silver, gold, copper oxide, and zinc oxide nanoparticles: a review Open
The understanding of nanomaterial toxicity is aided by biokinetic information pointing to potential target organs. Silver (Ag), copper oxide (CuO), and zinc oxide (ZnO) are often referred to as soluble materials in the literature. In addit…
View article: Toxicity of carbon nanomaterials: A model to predict ROS production from easily measurable surface characteristics
Toxicity of carbon nanomaterials: A model to predict ROS production from easily measurable surface characteristics Open
Toxicity pathways of engineered carbon nanomaterials, which have many and diverse industrial applications, include oxidative stress primarily due to the generation of reactive oxygen species (ROS). This study on 13 carbon black, 6 Graphene…
View article: Intratracheal instillation for the testing of pulmonary toxicity in mice—Effects of instillation devices and feed type on inflammation
Intratracheal instillation for the testing of pulmonary toxicity in mice—Effects of instillation devices and feed type on inflammation Open
Background Inhalation exposure is the gold standard when assessing pulmonary toxicity. However, it typically requires substantial amounts of test material. Intratracheal instillation is an alternative administration technique, where the te…
View article: Pro-inflammatory and genotoxic responses by metal oxide nanomaterials in alveolar epithelial cells and macrophages in submerged condition and air-liquid interface: An in vitro-in vivo correlation study
Pro-inflammatory and genotoxic responses by metal oxide nanomaterials in alveolar epithelial cells and macrophages in submerged condition and air-liquid interface: An in vitro-in vivo correlation study Open
Studies on in vitro-in vivo correlations of inflammatory and genotoxic responses are needed to advance new approach methodologies. Here, we assessed pro-inflammatory and genotoxic responses by 13 nanosized metal oxides (nMeOx) and quartz (…
View article: Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al. Open
commenting on the suggested health-based occupational exposure limit for zinc oxide made by the National Research Centre for the Working Environment (NFA) in Denmark (Hadrup et al. 2021b).In 2018, Christian Monsé and co-workers made a cont…
View article: Lessons from nanosafety research for effective regulation and safer handling of nanomaterials at the workplace
Lessons from nanosafety research for effective regulation and safer handling of nanomaterials at the workplace Open
At the turn of the twentieth century, nanotechnology was regarded as the new innovation potential. However, increased industrial use of nanomaterials raised concerns whether nanomaterial exposure could pose occupational health risks simila…
View article: Pleural inflammatory response, mesothelin content and DNA damage in mice at one-year after intra-pleural carbon nanotube administration
Pleural inflammatory response, mesothelin content and DNA damage in mice at one-year after intra-pleural carbon nanotube administration Open
Many in vitro and in vivo studies have shown that exposure to carbon nanotubes (CNTs) is associated with inflammation, oxidative stress and genotoxicity, although there is a paucity of studies on these effects in the pleural cavity. In the…
View article: Toxicity dose descriptors from animal inhalation studies of 13 nanomaterials and their bulk and ionic counterparts and variation with primary particle characteristics
Toxicity dose descriptors from animal inhalation studies of 13 nanomaterials and their bulk and ionic counterparts and variation with primary particle characteristics Open
This study collects toxicity data from animal inhalation studies of some nanomaterials and their bulk and ionic counterparts. To allow potential grouping and interpretations, we retrieved the primary physicochemical and exposure data to th…
View article: Toxicity dose descriptors from animal inhalation studies of 13 nanomaterials and their bulk and ionic counterparts and variation with primary particle characteristics
Toxicity dose descriptors from animal inhalation studies of 13 nanomaterials and their bulk and ionic counterparts and variation with primary particle characteristics Open
This study collects toxicity data from animal inhalation studies of some nanomaterials and their bulk and ionic counterparts. To allow potential grouping and interpretations, we retrieved the primary physicochemical and exposure data to th…
View article: Indoor PM <sub>2.5</sub> from occupied residences in Sweden caused higher inflammation in mice compared to outdoor PM <sub>2.5</sub>
Indoor PM <sub>2.5</sub> from occupied residences in Sweden caused higher inflammation in mice compared to outdoor PM <sub>2.5</sub> Open
We spend most of our time indoors; however, little is known about the effects of exposure to aerosol particles indoors. We aimed to determine differences in relative toxicity and physicochemical properties of PM2.5 collected simultaneously…
View article: Predicting nanomaterials pulmonary toxicity in animals by cell culture models: Achievements and perspectives
Predicting nanomaterials pulmonary toxicity in animals by cell culture models: Achievements and perspectives Open
Animal experiments are highly relevant models for the assessment of toxicological effects of engineered nanomaterials (ENMs), due to lack of biomonitoring and epidemiological studies. However, the expanding number of ENMs with different ph…
View article: Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids Open
To reduce, replace, and refine in vivo testing, there is increasing emphasis on the development of more physiologically relevant in vitro test systems to improve the reliability of non-animal-based methods for hazard assessment. When devel…
View article: Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study
Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study Open
Background The EU-project GRACIOUS developed an Integrated Approach to Testing and Assessment (IATA) to support grouping high aspect ratio nanomaterials (HARNs) presenting a similar inhalation hazard. Application of grouping reduces the ne…
View article: Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events
Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events Open
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-che…
View article: Systematic review on primary and secondary genotoxicity of carbon black nanoparticles in mammalian cells and animals
Systematic review on primary and secondary genotoxicity of carbon black nanoparticles in mammalian cells and animals Open
Carbon black exposure causes oxidative stress, inflammation and genotoxicity. The objective of this systematic review was to assess the contributions of primary (i.e. direct formation of DNA damage) and secondary genotoxicity (i.e., DNA le…
View article: Assessment of primary and inflammation-driven genotoxicity of carbon black nanoparticles <i>in vitro</i> and <i>in vivo</i>
Assessment of primary and inflammation-driven genotoxicity of carbon black nanoparticles <i>in vitro</i> and <i>in vivo</i> Open
Carbon black nanoparticles (CBNPs) have a large surface area/volume ratio and are known to generate oxidative stress and inflammation that may result in genotoxicity and cancer. Here, we evaluated the primary and inflammatory response-driv…
View article: Development of a standard operating procedure for the DCFH<sub>2</sub>-DA acellular assessment of reactive oxygen species produced by nanomaterials
Development of a standard operating procedure for the DCFH<sub>2</sub>-DA acellular assessment of reactive oxygen species produced by nanomaterials Open
Improved strategies are required for testing nanomaterials (NMs) to make hazard and risk assessment more efficient and sustainable. Including reduced reliance on animal models, without decreasing the level of human health protection. Acell…
View article: Development of a standard operating procedure for the DCFH<sub>2</sub>-DA acellular assessment of reactive oxygen species produced by nanomaterials
Development of a standard operating procedure for the DCFH<sub>2</sub>-DA acellular assessment of reactive oxygen species produced by nanomaterials Open
Improved strategies are required for testing nanomaterials (NMs) to make hazard and risk assessment more efficient and sustainable. Including reduced reliance on animal models, without decreasing the level of human health protection. Acell…
View article: Assessment of primary and inflammation-driven genotoxicity of carbon black nanoparticles <i>in vitro</i> and <i>in vivo</i>
Assessment of primary and inflammation-driven genotoxicity of carbon black nanoparticles <i>in vitro</i> and <i>in vivo</i> Open
Carbon black nanoparticles (CBNPs) have a large surface area/volume ratio and are known to generate oxidative stress and inflammation that may result in genotoxicity and cancer. Here, we evaluated the primary and inflammatory response-driv…
View article: Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures
Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures Open
With ever-increasing production and use of nanoparticles (NPs), there is a necessity to evaluate the probability of consequential adverse effects in individuals exposed to these particles. It is now understood that a proportion of NPs can …
View article: Pro-inflammatory response and genotoxicity caused by clay and graphene nanomaterials in A549 and THP-1 cells
Pro-inflammatory response and genotoxicity caused by clay and graphene nanomaterials in A549 and THP-1 cells Open
Nanoclays and graphene oxide nanomaterials represent a class of materials sharing similar shapes constituted of high aspect ratio platelets. The increased production of these materials for various industrial applications increases the risk…
View article: In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT
In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT Open
Background Multi-walled carbon nanotubes (MWCNT) have received attention due to extraordinary properties, resulting in concerns for occupational health and safety. Costs and ethical concerns of animal testing drive a need for in vitro mode…
View article: Genotoxicity of multi-walled carbon nanotube reference materials in mammalian cells and animals
Genotoxicity of multi-walled carbon nanotube reference materials in mammalian cells and animals Open
Carbon nanotubes (CNTs) were the first nanomaterials to be evaluated by the International Agency for Research on Cancer (IARC). The categorization as possibly carcinogenic agent to humans was only applicable to multi-walled carbon nanotube…
View article: Integrative approach in a safe by design context combining risk, life cycle and socio-economic assessment for safer and sustainable nanomaterials
Integrative approach in a safe by design context combining risk, life cycle and socio-economic assessment for safer and sustainable nanomaterials Open
Moving towards safe and sustainable innovations is an international policy ambition. In the on-hand manuscript, a concept combining safe by design and sustainability was implemented through the integration of human and environmental risk a…
View article: Towards FAIR nanosafety data
Towards FAIR nanosafety data Open
Nanotechnology is a key enabling technology with billions of euros in global investment from public funding, which include large collaborative projects that have investigated environmental and health safety aspects of nanomaterials, but th…
View article: NanoReg2 - eNanoMapper database
NanoReg2 - eNanoMapper database Open
H2020 NanoReg2 project data SQL dump for AMBIT chemical substance data management software. See AMBIT Docker for import instructions. Available online in the NanoReg2 - eNanoMapper database. A user guide is available.
View article: NanoReg2 - eNanoMapper database
NanoReg2 - eNanoMapper database Open
H2020 NanoReg2 project data SQL dump for AMBIT chemical substance data management software. See AMBIT Docker for import instructions. Available online in the NanoReg2 - eNanoMapper database. A user guide is available.
View article: An integrated approach to testing and assessment of high aspect ratio nanomaterials and its application for grouping based on a common mesothelioma hazard
An integrated approach to testing and assessment of high aspect ratio nanomaterials and its application for grouping based on a common mesothelioma hazard Open
Here we describe the development of an Integrated Approach to Testing and Assessment (IATA) to support the grouping of different types (nanoforms; NFs) of High Aspect Ratio Nanomaterials (HARNs), based on their potential to cause mesotheli…