Nickolas Steinauer
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View article: Hepatolithiasis and Choledocholithiasis Secondary to Warm Autoimmune Hemolytic Anemia in the Setting of COVID-19 and Lupus
Hepatolithiasis and Choledocholithiasis Secondary to Warm Autoimmune Hemolytic Anemia in the Setting of COVID-19 and Lupus Open
Two major etiologies of hyperbilirubinemia include hemolysis and cholestasis. Although rare, the former can give rise to the latter through the formation of pigment gallstones and subsequent biliary tree obstruction. We report a case of a …
View article: Cladribine plus cytarabine plus venetoclax in acute myeloid leukemia relapsed or refractory to venetoclax plus hypomethylating agent
Cladribine plus cytarabine plus venetoclax in acute myeloid leukemia relapsed or refractory to venetoclax plus hypomethylating agent Open
Not available.
View article: Patients with telomere biology disorders show context specific somatic mosaic states with high frequency of <scp><i>U2AF1</i></scp> variants
Patients with telomere biology disorders show context specific somatic mosaic states with high frequency of <span><i>U2AF1</i></span> variants Open
Somatic mosaic states in telomere biology disorders are characterized by somatic variants in the spliceosome and DNA damage response and repair pathways. A likely maladaptive response to short telomeres that may lead to increased hematolog…
View article: International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023 Open
View article: Spatiotemporal mapping of neurogenic gene expression during mammalian retinal development
Spatiotemporal mapping of neurogenic gene expression during mammalian retinal development Open
View article: Computational Modeling of Gene-Specific Transcriptional Repression, Activation and Chromatin Interactions in Leukemogenesis by LASSO-Regularized Logistic Regression
Computational Modeling of Gene-Specific Transcriptional Repression, Activation and Chromatin Interactions in Leukemogenesis by LASSO-Regularized Logistic Regression Open
Many physiological and pathological pathways are dependent on gene-specific on/off regulation of transcription. Some genes are repressed, while others are activated. Although many previous studies have analyzed the mechanisms of gene-speci…
View article: The transcriptional corepressor CBFA2T3 inhibits all-trans-retinoic acid–induced myeloid gene expression and differentiation in acute myeloid leukemia
The transcriptional corepressor CBFA2T3 inhibits all-trans-retinoic acid–induced myeloid gene expression and differentiation in acute myeloid leukemia Open
CBFA2/RUNX1 partner transcriptional co-repressor 3 (CBFA2T3, also known as MTG16 or ETO2) is a myeloid translocation gene family protein that functions as a master transcriptional corepressor in hematopoiesis. Recently, it has been shown t…
View article: Histone deacetylase 3 preferentially binds and collaborates with the transcription factor RUNX1 to repress AML1–ETO–dependent transcription in t(8;21) AML
Histone deacetylase 3 preferentially binds and collaborates with the transcription factor RUNX1 to repress AML1–ETO–dependent transcription in t(8;21) AML Open
View article: LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer
LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer Open
Triple-negative breast cancer (TNBC) is a highly aggressive subtype that is untreatable with hormonal or HER2-targeted therapies and is also typically unresponsive to checkpoint-blockade immunotherapy. Within the tumor microenvironment dys…
View article: Myeloid translocation gene CBFA2T3 directs a relapse gene program and determines patient-specific outcomes in AML
Myeloid translocation gene CBFA2T3 directs a relapse gene program and determines patient-specific outcomes in AML Open
CBFA2T3 is a master transcriptional coregulator in hematopoiesis. In this study, we report novel functions of CBFA2T3 in acute myeloid leukemia (AML) relapse. CBFA2T3 regulates cell-fate genes to establish gene expression signatures associ…
View article: Emerging Roles of MTG16 in Cell-Fate Control of Hematopoietic Stem Cells and Cancer
Emerging Roles of MTG16 in Cell-Fate Control of Hematopoietic Stem Cells and Cancer Open
MTG16 (myeloid translocation gene on chromosome 16) and its related proteins, MTG8 and MTGR1, define a small family of transcriptional corepressors. These corepressors share highly conserved domain structures yet have distinct biological f…
View article: New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins
New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins Open