Nico Bunzeck
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View article: Dopaminergic modulation of schema-dependent learning
Dopaminergic modulation of schema-dependent learning Open
Background Long-term memory for novel information can be supported by presenting it within a known semantic context. This so-called congruency effect has long been described as an example for schema-dependent learning, but the underlying n…
View article: Dopaminergic modulation of schema-dependent learning
Dopaminergic modulation of schema-dependent learning Open
Background Long-term memory for novel information can be supported by presenting it within a known semantic context. This so-called congruency effect has long been described as an example for schema-dependent learning, but the underlying n…
View article: Curiosity and surprise differentially affect memory depending on age
Curiosity and surprise differentially affect memory depending on age Open
State and trait epistemic curiosity can promote various aspects of cognition and behavior. However, possible age-related changes, a link to surprise, and formal education remain understudied. In three behavioral experiments, with n = 54 in…
View article: Curiosity and surprise differentially affect memory depending on age
Curiosity and surprise differentially affect memory depending on age Open
State and trait epistemic curiosity can promote various aspects of cognition and behavior. However, possible age-related changes, a link to surprise,and formal education remain understudied. In three behavioralexperiments, with n=54 inexpe…
View article: Dopaminergic prefrontal connectivity promotes schema-dependent learning
Dopaminergic prefrontal connectivity promotes schema-dependent learning Open
Long-term memory for novel information can be supported by presenting it within a known semantic context. This so-called congruency effect has long been described as an example for schema-dependent learning, but the underlying neural mecha…
View article: Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learning
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learning Open
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Dise…
View article: Curiosity and surprise differentially affect memory depending on age
Curiosity and surprise differentially affect memory depending on age Open
State and trait epistemic curiosity can promote various aspects of cognition and behavior. However, possible age-related changes, a link to surprise, and the impact on formal education remain understudied. In three behavioral experiments, …
View article: Globus pallidus iron relates to cognitive impairment in Alzheimer‘s disease: Evidence from MRI-based meta-analysis
Globus pallidus iron relates to cognitive impairment in Alzheimer‘s disease: Evidence from MRI-based meta-analysis Open
BACKGROUND Iron plays an essential role in brain metabolism and, therefore, cognitive functioning. However, region specific iron level increases during healthy and, even more so, pathological aging, in particular Alzheimer’s disease, can h…
View article: The basal forebrain serves social information processing
The basal forebrain serves social information processing Open
Empirical evidence suggests a critical, but little-understood, contribution of the basal forebrain (BF) to motivational aspects of social cognition. Therefore, we review the current literature on reward and punishment processing in the BF,…
View article: Predicting MCI and Alzheimer’s disease on structural brain integrity with machine learning
Predicting MCI and Alzheimer’s disease on structural brain integrity with machine learning Open
INTRODUCTION Machine learning on structural MRI brain data offers novel ways to characterize the underlying principles and developmental trajectories of healthy and pathological aging. While previous work on Alzheimer’s disease has shown t…
View article: Trajectories and contributing factors of neural compensation in healthy and pathological aging
Trajectories and contributing factors of neural compensation in healthy and pathological aging Open
Neural degeneration is a hallmark of healthy aging and can be associated with specific cognitive impairments. However, neural degeneration per se is not matched by unremitting declines in cognitive abilities. Instead, middle-aged and older…
View article: Structural degeneration of the nucleus basalis of Meynert in mild cognitive impairment and Alzheimer’s disease – Evidence from an MRI-based meta-analysis
Structural degeneration of the nucleus basalis of Meynert in mild cognitive impairment and Alzheimer’s disease – Evidence from an MRI-based meta-analysis Open
Recent models of Alzheimer's disease (AD) suggest that neuropathological changes of the medial temporal lobe, especially entorhinal cortex, are preceded by degenerations of the cholinergic Nucleus basalis of Meynert (NbM). Evidence from im…
View article: Structural Degeneration of the Nucleus basalis of Meynert in Mild Cognitive Impairment and Alzheimer’s Disease – Evidence from an MRI-based Meta-Analysis
Structural Degeneration of the Nucleus basalis of Meynert in Mild Cognitive Impairment and Alzheimer’s Disease – Evidence from an MRI-based Meta-Analysis Open
Recent models of Alzheimer’s Disease (AD) suggest that neuropathological changes of the medial temporal lobe, especially entorhinal cortex, are preceded by degenerations of the cholinergic Nucleus basalis of Meynert (NbM). Evidence from im…
View article: The Basal Forebrain Serves Social Information Processing
The Basal Forebrain Serves Social Information Processing Open
Empirical evidence suggests a critical, but little understood, contribution of the basal forebrain (BF) to motivational aspects of social cognition. Therefore, we review the current literature on reward and punishment processing in the BF,…
View article: Effects of positive and negative social feedback on motivation, evaluative learning, and socio-emotional processing
Effects of positive and negative social feedback on motivation, evaluative learning, and socio-emotional processing Open
Social rewards and punishments are strong motivators. Since experimental work has focused on young adults using simplistic feedback, the effects of more naturalistic stimuli on motivation, evaluative learning, and socio-emotional processin…
View article: Differential effects of expectancy on memory formation in young and older adults
Differential effects of expectancy on memory formation in young and older adults Open
Novelty can promote subsequent long‐term memory via the mesolimbic system, including the medial temporal lobe and midbrain structures. Importantly, these and other brain regions typically degenerate during healthy aging, which suggests a r…
View article: Anticipating social feedback involves basal forebrain and mesolimbic functional connectivity
Anticipating social feedback involves basal forebrain and mesolimbic functional connectivity Open
The mesolimbic system and basal forebrain (BF) are implicated in processing rewards and punishment, but their interplay and functional properties of subregions with respect to future social outcomes remain unclear. Therefore, this study in…
View article: Basal forebrain activity predicts functional degeneration in the entorhinal cortex and decreases with Alzheimer’s Disease progression
Basal forebrain activity predicts functional degeneration in the entorhinal cortex and decreases with Alzheimer’s Disease progression Open
BACKGROUND AND OBJECTIVES Recent models of Alzheimer’s Disease (AD) suggest the nucleus basalis of Meynert (NbM) as the origin of structural degeneration followed by the entorhinal cortex (EC). However, the functional properties of NbM and…
View article: Basal forebrain activity predicts functional degeneration in the entorhinal cortex in Alzheimer’s disease
Basal forebrain activity predicts functional degeneration in the entorhinal cortex in Alzheimer’s disease Open
Recent models of Alzheimer’s disease suggest the nucleus basalis of Meynert (NbM) as an early origin of structural degeneration followed by the entorhinal cortex (EC). However, the functional properties of NbM and EC regarding amyloid-β an…
View article: Cognitive parameters can predict change of walking performance in advanced Parkinson’s disease – Chances and limits of early rehabilitation
Cognitive parameters can predict change of walking performance in advanced Parkinson’s disease – Chances and limits of early rehabilitation Open
Introduction Links between cognition and walking performance in patients with Parkinson’s disease (PD), which both decline with disease progression, are well known. There is lack of knowledge regarding the predictive value of cognition for…
View article: Impaired episodic memory in PTSD patients — A meta-analysis of 47 studies
Impaired episodic memory in PTSD patients — A meta-analysis of 47 studies Open
Episodic memory impairments beyond the traumatic event might be a characteristic hallmark of post-traumatic stress disorder (PTSD). Although several studies support such a claim, empirical findings are inconsistent. Therefore, we performed…
View article: Contextual incongruency triggers memory reinstatement and the disruption of neural stability
Contextual incongruency triggers memory reinstatement and the disruption of neural stability Open
Schemas, or internal representation models of the environment, are thought to be central in organising our everyday life behaviour by giving stability and predictiveness to the structure of the world. However, when an element from an unfol…
View article: Does Executive Function Influence Walking in Acutely Hospitalized Patients With Advanced Parkinson's Disease: A Quantitative Analysis
Does Executive Function Influence Walking in Acutely Hospitalized Patients With Advanced Parkinson's Disease: A Quantitative Analysis Open
Introduction It is well-known that, in Parkinson's disease (PD), executive function (EF) and motor deficits lead to reduced walking performance. As previous studies investigated mainly patients during the compensated phases of the disease,…
View article: Set Size of Information in Long-Term Memory Similarly Modulates Retrieval Dynamics in Young and Older Adults
Set Size of Information in Long-Term Memory Similarly Modulates Retrieval Dynamics in Young and Older Adults Open
Our ability to rapidly distinguish new from already stored (old) information is important for behavior and decision making, but the underlying processes remain unclear. Here, we tested the hypothesis that contextual cues lead to a preselec…
View article: Novelty processing associated with neural beta oscillations improves recognition memory in young and older adults
Novelty processing associated with neural beta oscillations improves recognition memory in young and older adults Open
Novelty anticipation activates the mesolimbic system and promotes subsequent long‐term memory in younger adults. Importantly, mesolimbic structures typically degenerate with age, which might reduce positive effects of novelty anticipation.…
View article: Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans
Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans Open
Retrieval practice improves retention of information in long-term memory more than restudy, but the underlying neural mechanisms of this “retrieval practice effect” (RPE) remain poorly understood. Therefore, we investigated the behavioral …
View article: Anticipating social incentives recruits alpha-beta oscillations in the human substantia nigra and invigorates behavior across the life span
Anticipating social incentives recruits alpha-beta oscillations in the human substantia nigra and invigorates behavior across the life span Open
Anticipating social and non-social incentives recruits shared brain structures and promotes behavior. However, little is known about possible age-related behavioral changes, and how the human substantia nigra (SN) signals positive and nega…