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View article: SURG-17. A comprehensive framework for intraoperative mapping and monitoring, and perioperative neurological, linguistic, and outcome assessment in glioma resection: Consensus recommendations from the PIONEER Consortium and RANO resect group
SURG-17. A comprehensive framework for intraoperative mapping and monitoring, and perioperative neurological, linguistic, and outcome assessment in glioma resection: Consensus recommendations from the PIONEER Consortium and RANO resect group Open
BACKGROUND In diffuse glioma patients, greater extent of resection is associated with longer survival. Intraoperative mapping and monitoring are essential to maximize safe resection by identifying and preserving functional areas. Despite w…
View article: P12.60.A PATIENT AGE IS RELATED TO FAVORABLE ASSOCIATION OF SUPRAMAXIMAL RESECTION WITH OUTCOME IN GLIOBLASTOMA - A REPORT OF THE RANO RESECT GROUP
P12.60.A PATIENT AGE IS RELATED TO FAVORABLE ASSOCIATION OF SUPRAMAXIMAL RESECTION WITH OUTCOME IN GLIOBLASTOMA - A REPORT OF THE RANO RESECT GROUP Open
BACKGROUND The oncological role of resection in elderly patients with glioblastoma remains controversial. We evaluated the value of resection in patients ≥65 years with (I) newly diagnosed and (II) recurrent glioblastoma by comparing the p…
View article: OS11.6.A A COMPREHENSIVE FRAMEWORK FOR INTRAOPERATIVE MAPPING AND MONITORING, AND PERIOPERATIVE NEUROLOGICAL, LINGUISTIC, AND OUTCOME ASSESSMENT IN GLIOMA RESECTION: CONSENSUS RECOMMENDATIONS FROM THE PIONEER CONSORTIUM AND RANO RESECT GROUP
OS11.6.A A COMPREHENSIVE FRAMEWORK FOR INTRAOPERATIVE MAPPING AND MONITORING, AND PERIOPERATIVE NEUROLOGICAL, LINGUISTIC, AND OUTCOME ASSESSMENT IN GLIOMA RESECTION: CONSENSUS RECOMMENDATIONS FROM THE PIONEER CONSORTIUM AND RANO RESECT GROUP Open
BACKGROUND In adult patients with diffuse glioma, greater extent of resection is associated with longer overall and progression-free survival. Intraoperative mapping and monitoring techniques are essential to safely achieve maximum resecti…
View article: OS08.6.A A PROGNOSTIC CLASSIFICATION SYSTEM FOR EXTENT OF RESECTION IN IDH-MUTANT GRADE 2 GLIOMA: A REPORT BY THE RANO RESECT GROUP
OS08.6.A A PROGNOSTIC CLASSIFICATION SYSTEM FOR EXTENT OF RESECTION IN IDH-MUTANT GRADE 2 GLIOMA: A REPORT BY THE RANO RESECT GROUP Open
BACKGROUND The effects of resection in IDH-mutant grade 2 gliomas remain controversial since terminology for extent of resection was inconsistent across trials. We aimed to (I) establish a standardized classification system for extent of r…
View article: P07.10.B INTER-RATER AGREEMENT FROM A MULTI-NATIONAL EXPERT PANEL ON RESECTABILITY OF RECURRENT GLIOBLASTOMA: A COMPLEMENTARY POST-HOC ANALYSIS OF THE PROSPECTIVE, RANDOMIZED DIRECTOR TRIAL
P07.10.B INTER-RATER AGREEMENT FROM A MULTI-NATIONAL EXPERT PANEL ON RESECTABILITY OF RECURRENT GLIOBLASTOMA: A COMPLEMENTARY POST-HOC ANALYSIS OF THE PROSPECTIVE, RANDOMIZED DIRECTOR TRIAL Open
BACKGROUND The role of re-resection in recurrent glioblastoma remains controversial. Associations between higher extents of re-resection and prolonged survival might be explained by the assumption that tumors in less functional (surgically…
View article: A Novel Vascular Model Yields Increased MR Perfusion Metrics Compared to Conventional Dynamic Susceptibility Contrast Algorithms In Untreated Glioblastoma
A Novel Vascular Model Yields Increased MR Perfusion Metrics Compared to Conventional Dynamic Susceptibility Contrast Algorithms In Untreated Glioblastoma Open
Background Malignant gliomas are heterogeneous brain tumors with extensive neovascularization. Conventional gradient-echo dynamic susceptibility contrast (GRE-DSC) perfusion MRI may underestimate microvascular alterations. We hypothesized …
View article: Clinical and neuropathological criteria for distinguishing between IDH-mutant astrocytomas of WHO grade 2 and 3
Clinical and neuropathological criteria for distinguishing between IDH-mutant astrocytomas of WHO grade 2 and 3 Open
Background The 2021 WHO classification of CNS tumors allows flexibility in the grading of IDH-mutant astrocytic gliomas, leading to some ambiguity. Following the approval of vorasidenib for WHO grade 2 astrocytomas and oligodendrogliomas b…
View article: Patient age is related to favorable association of supramaximal resection with outcome in glioblastoma – a report of the RANO resect group
Patient age is related to favorable association of supramaximal resection with outcome in glioblastoma – a report of the RANO resect group Open
View article: Navigating in the dark: Tailoring the extent of resection in gliomas with <i>FastGlioma</i>
Navigating in the dark: Tailoring the extent of resection in gliomas with <i>FastGlioma</i> Open
View article: Development and validation of a clinical risk model for postoperative outcome in newly diagnosed glioblastoma: A report of the RANO <i>resect</i> group
Development and validation of a clinical risk model for postoperative outcome in newly diagnosed glioblastoma: A report of the RANO <i>resect</i> group Open
Background Following surgery, patients with newly diagnosed glioblastoma frequently enter clinical trials. Nuanced risk assessment is warranted to reduce imbalances between study arms. Here, we aimed (I) to analyze the interactive effects …
View article: PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cell in lung cancer brain metastasis
PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cell in lung cancer brain metastasis Open
View article: PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cells in lung cancer brain metastasis.
PD-1 blockade does not improve efficacy of EpCAM-directed CAR T-cells in lung cancer brain metastasis. Open
Background Lung cancer brain metastasis have a devastating prognosis, necessitating innovative treatment strategies. While chimeric antigen receptor (CAR) T-cells show promise in hematologic malignancies, their efficacy in solid tumors, in…
View article: Perifocal edema is a risk factor for preoperative seizures in patients with meningioma WHO grade 2 and 3
Perifocal edema is a risk factor for preoperative seizures in patients with meningioma WHO grade 2 and 3 Open
Background Patients with intracranial meningiomas frequently suffer from tumor-related seizures prior to resection, impacting patients’ quality of life. We aimed to elaborate on incidence and predictors for seizures in a patient cohort wit…
View article: 10.02 Combined anti-angiogenic treatment to increase intratumoral persistence of CAR T-cells in lung cancer brain metastases
10.02 Combined anti-angiogenic treatment to increase intratumoral persistence of CAR T-cells in lung cancer brain metastases Open
Background Brain metastasis in lung cancer carries a devastating prognosis, emphasizing the urgent clinical demand for innovative therapeutic strategies. While immunotherapeutic approaches such as the treatment with chimeric antigen recept…
View article: P12.10 <i>In vivo</i> dynamics and anti-tumor effects of B7-H3-directed CAR T-cells in an orthotopic medulloblastoma mouse model
P12.10 <i>In vivo</i> dynamics and anti-tumor effects of B7-H3-directed CAR T-cells in an orthotopic medulloblastoma mouse model Open
Background The majority of solid tumors in pediatric patients occurs in the central nervous system, with medulloblastoma accounting for approximately 20% of pediatric brain tumors. Current treatment, involving resection, radiotherapy, and …
View article: Astrocytomas of the spinal cord
Astrocytomas of the spinal cord Open
Tumors of astrocytic origin represent one of the most frequent entities among the overall rare group of spinal cord gliomas. Initial clinical symptoms are often unspecific, and sensorimotor signs localizing to the spinal cord occur with pr…
View article: Evaluation of surgical treatment strategies and outcome for cerebral arachnoid cysts in children and adults
Evaluation of surgical treatment strategies and outcome for cerebral arachnoid cysts in children and adults Open
Objective The best treatment strategies for cerebral arachnoid cysts (CAC) are still up for debate. In this study, we present CAC management, outcome data, and risk factors for recurrence after surgical treatment, focusing on microscopic/e…
View article: Risk-benefit analysis of surgical treatment strategies for cystic craniopharyngioma in children and adolescents
Risk-benefit analysis of surgical treatment strategies for cystic craniopharyngioma in children and adolescents Open
Objective Treatment strategies for craniopharyngiomas are still under debate particularly for the young population. We here present tumor control and functional outcome data after surgical treatment focusing on stereotactic and microsurgic…
View article: Associations between recurrence patterns and outcome in glioblastoma patients undergoing re-resection: A complementary report of the RANO <i>resect</i> group
Associations between recurrence patterns and outcome in glioblastoma patients undergoing re-resection: A complementary report of the RANO <i>resect</i> group Open
Journal Article Associations between recurrence patterns and outcome in glioblastoma patients undergoing re-resection: A complementary report of the RANO resect group Get access Philipp Karschnia, Philipp Karschnia Department of Neurosurge…
View article: EXTH-25. <i>IN VIVO</i> TWO-PHOTON TUMOR IMAGING IN AN ORTHOTOPIC MEDULLOBLASTOMA MOUSE MODEL
EXTH-25. <i>IN VIVO</i> TWO-PHOTON TUMOR IMAGING IN AN ORTHOTOPIC MEDULLOBLASTOMA MOUSE MODEL Open
BACKGROUND Medulloblastoma represents the most common primary brain malignancy in pediatric patients and is associated with neuro-cognitive impairment and frequent relapses after aggressive multimodal therapy. Adoptive immunotherapies such…
View article: EXTH-73. IN VIVO EFFECTS OF EPCAM-DIRECTED CAR T CELLS IN COMBINATION WITH PD-1 CHECKPOINT BLOCKADE IN LUNG CANCER BRAIN METASTASIS
EXTH-73. IN VIVO EFFECTS OF EPCAM-DIRECTED CAR T CELLS IN COMBINATION WITH PD-1 CHECKPOINT BLOCKADE IN LUNG CANCER BRAIN METASTASIS Open
BACKGROUND Metastatic lung cancer is incurable once it spreads to the brain. Chimeric antigen receptor (CAR) T cells show promise in hematologic malignancies but face challenges in solid tumors, particularly in brain tumors, due to a highl…
View article: NIMG-75. POSTOPERATIVE68GA-DOTATATE/PET-CT IMAGING IS PROGNOSTIC FOR PROGRESSION-FREE SURVIVAL IN MENINGIOMA WHO GRADE 1: A PROSPECTIVE SINGLE-CENTER STUDY
NIMG-75. POSTOPERATIVE68GA-DOTATATE/PET-CT IMAGING IS PROGNOSTIC FOR PROGRESSION-FREE SURVIVAL IN MENINGIOMA WHO GRADE 1: A PROSPECTIVE SINGLE-CENTER STUDY Open
PURPOSE Microsurgical tumor resection represents the first-line treatment for symptomatic meningiomas, and extent of resection has been shown to be of prognostic importance. Assessment of tumor remnants with somatostatin receptor PET prove…
View article: SURG-21. THE PROGNOSTIC ROLE OF RE-RESECTION FOR RECURRENT GLIOBLASTOMA: A REPORT OF THE RANO <i>RESECT</i> GROUP USING A NOVEL CLASSIFICATION FOR EXTENT OF RESECTION
SURG-21. THE PROGNOSTIC ROLE OF RE-RESECTION FOR RECURRENT GLIOBLASTOMA: A REPORT OF THE RANO <i>RESECT</i> GROUP USING A NOVEL CLASSIFICATION FOR EXTENT OF RESECTION Open
BACKGROUND The role of re-resection in recurrent glioblastoma remains controversial since leaving certain tumor volumes deliberately behind cannot be ethically justified. We aimed to (I) analyze the prognostic value of re-resection using t…
View article: INNV-06. SIGNIFICANCE OF MOLECULAR DIAGNOSTICS FOR THERAPEUTIC DECISION-MAKING IN RECURRENT GLIOMA
INNV-06. SIGNIFICANCE OF MOLECULAR DIAGNOSTICS FOR THERAPEUTIC DECISION-MAKING IN RECURRENT GLIOMA Open
BACKGROUND Targeted therapies have substantially improved survival in cancer patients with malignancies outside the brain. Whether in-depth analysis for molecular alterations may also offer therapeutic avenues in primary brain tumors remai…
View article: Surgical management and outcome of newly diagnosed glioblastoma without contrast enhancement (<i>low-grade appearance</i>): a report of the RANO <i>resect</i> group
Surgical management and outcome of newly diagnosed glioblastoma without contrast enhancement (<i>low-grade appearance</i>): a report of the RANO <i>resect</i> group Open
Background Resection of the contrast-enhancing (CE) tumor represents the standard of care in newly diagnosed glioblastoma. However, some tumors ultimately diagnosed as glioblastoma lack contrast enhancement and have a ‘low-grade appearance…
View article: P15.11.B POSTOPERATIVE68GA-DOTATATE/PET-CT IMAGING IS PROGNOSTIC FOR PROGRESSION-FREE SURVIVAL IN MENINGIOMA WHO GRADE 1: A PROSPECTIVE SINGLE-CENTER STUDY
P15.11.B POSTOPERATIVE68GA-DOTATATE/PET-CT IMAGING IS PROGNOSTIC FOR PROGRESSION-FREE SURVIVAL IN MENINGIOMA WHO GRADE 1: A PROSPECTIVE SINGLE-CENTER STUDY Open
BACKGROUND Microsurgical tumor resection represents the first-line treatment for symptomatic meningiomas, and extent of resection has been shown to be of prognostic importance. Assessment of tumor remnants with somatostatin receptor PET pr…
View article: OS09.1.A<i>IN VIVO</i>TWO-PHOTON TUMOR IMAGING IN AN ORTHOTOPIC MEDULLOBLASTOMA MOUSE MODEL
OS09.1.A<i>IN VIVO</i>TWO-PHOTON TUMOR IMAGING IN AN ORTHOTOPIC MEDULLOBLASTOMA MOUSE MODEL Open
BACKGROUND Medulloblastoma represents the most common primary brain malignancy in pediatric patients and is associated with neuro-cognitive impairment and frequent relapses after aggressive multimodal therapy. Adoptive immunotherapies such…
View article: P11.09.A SIGNIFICANCE OF MOLECULAR DIAGNOSTICS FOR THERAPEUTIC DECISION MAKING IN RECURRENT GLIOMA
P11.09.A SIGNIFICANCE OF MOLECULAR DIAGNOSTICS FOR THERAPEUTIC DECISION MAKING IN RECURRENT GLIOMA Open
BACKGROUND Targeted therapies have substantially improved survival in cancer patients with malignancies outside the brain. Whether in-depth analysis for molecular alterations may also offer therapeutic avenues in primary brain tumors remai…
View article: JS05.7.A SURGICAL RE-RESECTION FOR RECURRENT GLIOBLASTOMA: PROGNOSTIC EVALUATION USING THE NOVEL RANO CLASSIFICATION FOR EXTENT OF RESECTION FROM THE RANO<i>RESECT</i> GROUP
JS05.7.A SURGICAL RE-RESECTION FOR RECURRENT GLIOBLASTOMA: PROGNOSTIC EVALUATION USING THE NOVEL RANO CLASSIFICATION FOR EXTENT OF RESECTION FROM THE RANO<i>RESECT</i> GROUP Open
BACKGROUND The value of re-resection in recurrent glioblastoma remains controversial as a randomized trial that specifies intentional incomplete resection cannot be justified ethically. Here, we aimed to (I) explore the prognostic role of …
View article: Postoperative [68Ga]Ga-DOTA-TATE PET/CT imaging is prognostic for progression-free survival in meningioma WHO grade 1
Postoperative [68Ga]Ga-DOTA-TATE PET/CT imaging is prognostic for progression-free survival in meningioma WHO grade 1 Open