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View article: Expanding modeling boundaries to design more resilient vaccine supply networks
Expanding modeling boundaries to design more resilient vaccine supply networks Open
The COVID-19 pandemic shed light on the fragility of today's public health systems and failure to sufficiently invest in preparedness. These shortcomings are observed in delays achieving timely, equitable, and sufficient access to life-sav…
View article: Future-Proofing European Pharmaceutical Regulatory and Market Access Practices Based on EU Learnings from the COVID-19 Pandemic: Insights from Multi-Stakeholder Interviews
Future-Proofing European Pharmaceutical Regulatory and Market Access Practices Based on EU Learnings from the COVID-19 Pandemic: Insights from Multi-Stakeholder Interviews Open
Introduction During the COVID-19 pandemic, regulatory and market access actions were taken to expedite the market entry of COVID-19 medicines. This study aims to (i) capture multi-stakeholder views on these actions, and (ii) provide recomm…
View article: Differentiated Services Delivery Model Uptake and Outcomes in Uganda: Gaps, Facilitators, and Barriers - A Mixed Methods Study 2019–2021
Differentiated Services Delivery Model Uptake and Outcomes in Uganda: Gaps, Facilitators, and Barriers - A Mixed Methods Study 2019–2021 Open
Background Differentiated service delivery (DSD) models have emerged as innovative approaches to optimize HIV service delivery, particularly in bridging gaps across the HIV test–treat–care cascade. We assessed the performance of DSD models…
View article: Developing an intuitive decision support system for equitable vaccine distribution during pandemics
Developing an intuitive decision support system for equitable vaccine distribution during pandemics Open
Effective organization of the vaccine supply chain is vital to achieve high vaccination rates in pandemics. This paper presents a novel approach for developing a decision support system (DSS) to support health officials and policymakers wh…
View article: Charting a novel path towards Ebola virus disease preparedness: Considerations for preventive vaccination
Charting a novel path towards Ebola virus disease preparedness: Considerations for preventive vaccination Open
In June 2024, Gavi, the Vaccine Alliance, launched a preventive vaccination program against Ebola virus disease (EVD). This marks a historic shift in the management of EVD, allowing at-risk countries across sub-Saharan Africa to request su…
View article: Shaping the future of global access to safe, effective, appropriate and quality health products
Shaping the future of global access to safe, effective, appropriate and quality health products Open
View article: Modeling Supply and Demand Dynamics of Vaccines against Epidemic-Prone Pathogens: Case Study of Ebola Virus Disease
Modeling Supply and Demand Dynamics of Vaccines against Epidemic-Prone Pathogens: Case Study of Ebola Virus Disease Open
Health emergencies caused by epidemic-prone pathogens (EPPs) have increased exponentially in recent decades. Although vaccines have proven beneficial, they are unavailable for many pathogens. Furthermore, achieving timely and equitable acc…
View article: OA-902 Fair partnerships as a key to empower African R&D stakeholders to advance equitable and sustained access to quality health products
OA-902 Fair partnerships as a key to empower African R&D stakeholders to advance equitable and sustained access to quality health products Open
To maximize the impact of the findings of clinical research, long-term plans for equitable access to new, innovative health products should be included right from the outset of R&D planning. This is a complex undertaking, that requires mu…
View article: High viral suppression and detection of dolutegravir-resistance associated mutations in treatment-experienced Tanzanian adults living with HIV-1 in Dar es Salaam
High viral suppression and detection of dolutegravir-resistance associated mutations in treatment-experienced Tanzanian adults living with HIV-1 in Dar es Salaam Open
View article: More than one crisis: COVID-19 response actors navigating multi-dimensional crises in Flanders, Belgium
More than one crisis: COVID-19 response actors navigating multi-dimensional crises in Flanders, Belgium Open
Funding Information: TK, LWH, TN, SD, KPG, AV, TGV, NV, CV, CG and CVR declare receiving a grant by Fonds Wetenschappelijk Onderzoek (FWO-Research Foundation – Flanders), to conduct social listening of vaccine concerns in Belgium. LWH, NV,…
View article: Guest editorial: Vaccine supply in perspective: from end-to-end supply chains to full-fledged immunization systems
Guest editorial: Vaccine supply in perspective: from end-to-end supply chains to full-fledged immunization systems Open
View article: Embracing context: Lessons from designing a dialogue-based intervention to address vaccine hesitancy
Embracing context: Lessons from designing a dialogue-based intervention to address vaccine hesitancy Open
Dialogue with people who are vaccine hesitant has been recommended as a method to increase vaccination uptake. The process of cultivating dialogue is shaped by the context in which it occurs, yet the development of interventions addressing…
View article: Data, analytical techniques and collaboration between researchers and practitioners in humanitarian health supply chains: a challenging but necessary way forward
Data, analytical techniques and collaboration between researchers and practitioners in humanitarian health supply chains: a challenging but necessary way forward Open
Purpose This paper aims to provide a discussion on the interface and interactions between data, analytical techniques and impactful research in humanitarian health supply chains. New techniques for data capturing, processing and analytics,…
View article: HPR205 Future-Proofing European Regulatory and Market Access Practices Based on Learnings From the COVID-19 Pandemic – Stakeholder Perspectives
HPR205 Future-Proofing European Regulatory and Market Access Practices Based on Learnings From the COVID-19 Pandemic – Stakeholder Perspectives Open
View article: SA13 The Impact of the COVID-19 Pandemic on Collaboration and Innovation in Antiviral Drug Development: A Multi-Stakeholder Systems Dynamics Analysis
SA13 The Impact of the COVID-19 Pandemic on Collaboration and Innovation in Antiviral Drug Development: A Multi-Stakeholder Systems Dynamics Analysis Open
View article: How Can Authorities Support Distributed Improvisation During Major Crises? A Study of Decision Bottlenecks Arising During Local COVID-19 Vaccine Roll-Out
How Can Authorities Support Distributed Improvisation During Major Crises? A Study of Decision Bottlenecks Arising During Local COVID-19 Vaccine Roll-Out Open
Despite the increased importance attributed to distributed improvisation in major crises, few studies investigate how central authorities can promote a harmonic, coordinated national response while allowing for distributed autonomy and imp…
View article: Strategic silences, eroded trust: The impact of divergent COVID-19 vaccine sentiments on healthcare workers' relations with peers and patients
Strategic silences, eroded trust: The impact of divergent COVID-19 vaccine sentiments on healthcare workers' relations with peers and patients Open
View article: HIV and SARS-CoV-2: the interplay of two wicked problems
HIV and SARS-CoV-2: the interplay of two wicked problems Open
Funding Information: This work was funded by VLIR-UOS, grant numbers TZ2019SIN263 and TZ2020JOI032A101. Publisher Copyright: ©
View article: Exploring the mechanisms behind HIV drug resistance in sub-Saharan Africa: conceptual mapping of a complex adaptive system based on multi-disciplinary expert insights
Exploring the mechanisms behind HIV drug resistance in sub-Saharan Africa: conceptual mapping of a complex adaptive system based on multi-disciplinary expert insights Open
View article: Additional file 1 of Exploring the mechanisms behind HIV drug resistance in sub-Saharan Africa: conceptual mapping of a complex adaptive system based on multi-disciplinary expert insights
Additional file 1 of Exploring the mechanisms behind HIV drug resistance in sub-Saharan Africa: conceptual mapping of a complex adaptive system based on multi-disciplinary expert insights Open
Additional file 1. HIVDR as a CAS, visualized in layers. Each element represents a factor influencing HIVDR and each line represents a connection between two factors. Factors are organized in five layers according to their connection with …
View article: Additional file 3 of Exploring the mechanisms behind HIV drug resistance in sub-Saharan Africa: conceptual mapping of a complex adaptive system based on multi-disciplinary expert insights
Additional file 3 of Exploring the mechanisms behind HIV drug resistance in sub-Saharan Africa: conceptual mapping of a complex adaptive system based on multi-disciplinary expert insights Open
Additional file 3. Interactive systems map and data set Excel file. Additional file 3 contains a weblink to an online interactive version of the systems maps included in the manuscript as Fig. 2 and Additional file 1. The second and third …
View article: Doubt at the core: Unspoken vaccine hesitancy among healthcare workers
Doubt at the core: Unspoken vaccine hesitancy among healthcare workers Open
View article: Factors Associated with HIV Drug Resistance in Dar es Salaam, Tanzania: Analysis of a Complex Adaptive System
Factors Associated with HIV Drug Resistance in Dar es Salaam, Tanzania: Analysis of a Complex Adaptive System Open
HIV drug resistance (HIVDR) is a complex problem with multiple interconnected and context dependent causes. Although the factors influencing HIVDR are known and well-studied, HIVDR remains a threat to the effectiveness of antiretroviral th…
View article: Toward a decision support system for COVID-19 vaccine allocation inside countries
Toward a decision support system for COVID-19 vaccine allocation inside countries Open
The distribution of COVID-19 vaccines has proved to be a challenging task for public health authorities in many countries. Among several decisions involved in the task, allocating limited available vaccines to administration points is inde…
View article: Insights into vaccine hesitancy from systems thinking, Rwanda
Insights into vaccine hesitancy from systems thinking, Rwanda Open
The application of behavioural frameworks and systems thinking revealed vaccine hesitancy mechanisms in Rwandan communities that demonstrate the interrelationship between immunization services and caregivers' vaccination behaviour. Confide…
View article: Vaccine supply chains in resource-limited settings: Mitigating the impact of rainy season disruptions
Vaccine supply chains in resource-limited settings: Mitigating the impact of rainy season disruptions Open
View article: Advancing sustainable development goals through immunization: a literature review
Advancing sustainable development goals through immunization: a literature review Open
View article: Identifying mechanisms behind HIV drug resistance in Sub-Saharan Africa: a systems approach
Identifying mechanisms behind HIV drug resistance in Sub-Saharan Africa: a systems approach Open
IntroductionHIV drug resistance (HIVDR) continues to threaten the effectiveness of worldwide antiretroviral therapy (ART). Emergence and transmission of HIVDR is driven by several interconnected factors. Though much has been done to uncove…
View article: A Systems-Based Framework for Immunisation System Design: Six Loops, Three Flows, Two Paradigms
A Systems-Based Framework for Immunisation System Design: Six Loops, Three Flows, Two Paradigms Open
Despite massive progress in vaccine coverage globally, the region of sub-Saharan Africa is lagging behind and not on track for Sustainable Development Goal 3 by 2030. Sub-national under-immunisation, related to geographical and social hete…
View article: Vaccine hesitancy - insights from two Rwandese settings
Vaccine hesitancy - insights from two Rwandese settings Open
Qualitative data related to vaccine hesitancy collected at two Rwandese settings between 2018-2020