Nicola K. Wilson
YOU?
Author Swipe
View article: CLADES: a hybrid NeuralODE-Gillespie approach for unveiling clonal cell fate and differentiation dynamics
CLADES: a hybrid NeuralODE-Gillespie approach for unveiling clonal cell fate and differentiation dynamics Open
View article: A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space
A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space Open
During gastrulation, mouse epiblast cells form the three germ layers that establish the body plan and initiate organogenesis. While single-cell atlases have advanced our understanding of lineage diversification, spatial aspects of differen…
View article: A Step-wise, Deterministic and Fatal Mouse Model of Myeloid Neoplasm with Spontaneous Acquisition of Patient-relevant RTK–RAS Mutations
A Step-wise, Deterministic and Fatal Mouse Model of Myeloid Neoplasm with Spontaneous Acquisition of Patient-relevant RTK–RAS Mutations Open
Leukaemia arises through the stepwise transformation of healthy haematopoietic cells, yet the asymptomatic premalignant phase and its progression to overt disease remain poorly understood. To model this process, we engineered a patient-der…
View article: A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche
A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche Open
Interactions of hematopoietic stem cells (HSCs) with the bone marrow microenvironment are critical to regulate stem cell function in homeostasis, emergency hematopoiesis and ageing. The dynamic behavior of endogenous HSCs in their niches h…
View article: Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia
Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia Open
View article: Eomes directs the formation of spatially and functionally diverse extraembryonic hematovascular tissues
Eomes directs the formation of spatially and functionally diverse extraembryonic hematovascular tissues Open
During mouse gastrulation, extraembryonic mesoderm (ExEM) contributes to the extraembryonic yolk sac (YS) and allantois, both of which are essential for successful gestation. Although the genetic networks coordinating intra-embryonic mesod…
View article: A single-cell and tissue-scale analysis suite resolves Mixl1’s role in heart development
A single-cell and tissue-scale analysis suite resolves Mixl1’s role in heart development Open
Perturbation studies using gene knockouts have become a key tool for understanding the roles of regulatory genes in development. However, large-scale studies dissecting the molecular role of development master regulators in every cell type…
View article: A subset of Haematopoietic Stem Cells resists <i>Plasmodium</i> infection-induced stress by uncoupling interferon sensing and metabolic activation
A subset of Haematopoietic Stem Cells resists <i>Plasmodium</i> infection-induced stress by uncoupling interferon sensing and metabolic activation Open
Summary Hematopoietic stem cells (HSCs) sustain lifelong haematopoiesis as their progeny differentiate into all blood cell lineages. Homeostatic HSCs are mostly quiescent and only rarely divide, however their proliferation and differentiat…
View article: Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells Open
View article: Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules
Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules Open
Summary Despite rapid advances in mapping genetic drivers and gene expression changes in hematopoietic stem cells (HSCs), there is a relative paucity of studies at the protein level. Here, we perform a deep, multi-omic characterization (ep…
View article: A Step-Wise, Deterministic and Fatal Mouse Model of Myeloid Neoplasm with Spontaneous Acquisition of Patient-Relevant RTK–RAS Mutations
A Step-Wise, Deterministic and Fatal Mouse Model of Myeloid Neoplasm with Spontaneous Acquisition of Patient-Relevant RTK–RAS Mutations Open
View article: A Spatiotemporal Atlas of Mouse Gastrulation and Early Organogenesis to Explore Axial Patterning and Project<i>In Vitro</i>Models onto<i>In Vivo</i>Space
A Spatiotemporal Atlas of Mouse Gastrulation and Early Organogenesis to Explore Axial Patterning and Project<i>In Vitro</i>Models onto<i>In Vivo</i>Space Open
SUMMARY At the onset of murine gastrulation, pluripotent epiblast cells migrate through the primitive streak, generating mesodermal and endodermal precursors, while the ectoderm arises from the remaining epiblast. Together, these germ laye…
View article: Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool
Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool Open
SUMMARY Somatic stem cell pools are comprised of diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative function. In the bone marrow, myeloid-biased HSC (myHSC) are indispensable for repl…
View article: Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition
Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition Open
Adult hematopoietic stem cells (HSCs) are responsible for the lifelong production of blood and immune cells, a process regulated by extracellular cues, including cytokines. Many cytokines signal through the conserved Janus kinase (JAK)/sig…
View article: Eomes directs the formation of spatially and functionally diverse extra-embryonic hematovascular tissues
Eomes directs the formation of spatially and functionally diverse extra-embryonic hematovascular tissues Open
Summary During mouse gastrulation, extraembryonic mesoderm (ExEM) contributes to the extraembryonic yolk sac (YS) and allantois, both of which are essential for successful gestation. Although the genetic networks coordinating intra-embryon…
View article: Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5
Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5 Open
Normal and malignant hematopoietic stem cells (HSCs) are controlled by extracellular cues including cytokine signalling through the JAK/STAT pathway. Here, we show that STAT5-deficient HSCs exhibit an unusual phenotype: while reduced multi…
View article: Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle
Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle Open
Loss of long-term hematopoietic stem cell (LT-HSC) function ex vivo hampers the success of clinical protocols that rely on culture. However, the kinetics and mechanisms through which this occurs remain incompletely characterized. In this s…
View article: Expression profiling of cerebrospinal fluid identifies dysregulated antiviral mechanisms in multiple sclerosis
Expression profiling of cerebrospinal fluid identifies dysregulated antiviral mechanisms in multiple sclerosis Open
Despite the overwhelming evidence that multiple sclerosis is an autoimmune disease, relatively little is known about the precise nature of the immune dysregulation underlying the development of the disease. Reasoning that the CSF from pati…
View article: Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes
Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes Open
View article: Bespoke single cell molecular and tissue-scale analysis reveals mechanisms underpinning development and disease in complex developing cell populations
Bespoke single cell molecular and tissue-scale analysis reveals mechanisms underpinning development and disease in complex developing cell populations Open
Perturbation studies using gene knockouts have become a key tool for understanding the roles of regulatory genes in development and disease. Here we systematically characterise the knockout effects of the key developmental regulators T and…
View article: Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection
Single‐cell multi‐omics analysis of COVID‐19 patients with pre‐existing autoimmune diseases shows aberrant immune responses to infection Open
In COVID‐19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre‐existing autoimmune conditions can therefore be at increased risk of severe COVID‐19 and/or associated sequelae, yet SARS‐CoV‐2 infe…
View article: Yolk sac cell atlas reveals multiorgan functions during human early development
Yolk sac cell atlas reveals multiorgan functions during human early development Open
The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconc…
View article: P1334: THE IMPACT OF SMALL MOLECULE INHIBITION OF METTL3 ON NORMAL HAEMATOPOIESIS
P1334: THE IMPACT OF SMALL MOLECULE INHIBITION OF METTL3 ON NORMAL HAEMATOPOIESIS Open
Topic: 23. Hematopoiesis, stem cells and microenvironment Background: Targeting RNA methylation by selective catalytic inhibition of the RNA methyltransferase METTL3 has shown significant promise as a therapeutic strategy against AML. Whil…
View article: Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages
Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages Open
View article: Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner Open
Aged hematopoietic stem cells (HSCs) display diminished self-renewal and a myeloid differentiation bias. However, the drivers and mechanisms that underpin this fundamental switch are not understood. HSCs produce genotoxic formaldehyde that…
View article: Adaptation to<i>ex vivo</i>culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner
Adaptation to<i>ex vivo</i>culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner Open
Loss of long-term haematopoietic stem cell function (LT-HSC) hampers the success of ex vivo HSC gene therapy and expansion procedures, but the kinetics and the mechanisms by which this occurs remain incompletely characterized. Here through…
View article: Introduction to a review series on single-cell genomics: getting ready for clinical impact in leukemia and myeloid neoplasms
Introduction to a review series on single-cell genomics: getting ready for clinical impact in leukemia and myeloid neoplasms Open
Edited by Associate Editor Berthold Göttgens, this Review Series focuses on how the use of single-cell genomic and multiomic analyses are broadening our understanding of the complexity of leukemias and myeloid neoplasms. For acute myeloid …
View article: Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia Open
View article: Multi-organ functions of yolk sac during human early development
Multi-organ functions of yolk sac during human early development Open
The yolk sac (YS) represents an evolutionarily-conserved extraembryonic structure that ensures timely delivery of nutritional support and oxygen to the developing embryo. However, the YS remains ill-defined in humans. We therefore assemble…
View article: Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation
Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation Open