Explanipedia

Deleterious effects of plastic component bisphenol a on mitochondrial function in human intestinal cells Open

Graziella Perra, Andrea Caddeo, Francesca Sedda, Giacomo Cao, Raffaella Isola , et al. · 2025

Plastic compounds released into the environment can be accumulated in human tissues causing various health issues. It has been demonstrated that Bisphenol A (BPA), widely used in polycarbonate plastics and food packaging, can accumulate in…

Corrigendum to “Osmotic injury and cytotoxicity for hMSCs in contact with Me2SO: The effect of cell size distribution” [Cryobiology 116 (2024) 104943] Open

Gabriele Traversari, Jakub Stas, Antonio Mario Locci, Alessandro Concas, Nicola Lai , et al. · 2025

Galectin-3 inhibition ameliorates hepatic steatosis in a multilineage 3D spheroid model Open

Francesca Sedda, Andrea Caddeo, Kavitha Sasidharan, Graziella Perra, Rajesh Pal , et al. · 2025

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease, and liver-related morbidity and mortality worldwide. MASLD is a multifactorial condition, which still needs to be co…

Tryptophan metabolites are altered when Caco-2 cells are exposed to simulated microgravity Open

Giulia Tolle, Amalia Di Petrillo, Massimo Claudio Fantini, Gabriele Serreli, Monica Deiana , et al. · 2025

Novel experimental and theoretical study on the synthesis and use of microalgae-derived silver nanomaterials for water purification Open

Agnieszka Sidorowicz, Federico Atzori, Federico Zedda, Giacomo Fais, Francesco Loy , et al. · 2024

A green procedure involving metabolites of the microalga Haematococcus pluvialis is proposed to synthesize silver nanoparticles (Ag NPs) capable of removing the polluting dye brilliant blue R (BBR) from water. The X-ray diffraction (XRD) a…

Cytotoxic Effects of ZnO and Ag Nanoparticles Synthesized in Microalgae Extracts on PC12 Cells Open

Giacomo Fais, Agnieszka Sidorowicz, Graziella Perra, Debora Dessì, Francesco Loy , et al. · 2024

The green synthesis of silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs), as well as Ag/Ag2O/ZnO nanocomposites (NCs), using polar and apolar extracts of Chlorella vulgaris, offers a sustainable method for producing nanomaterials with t…

Eco-Friendly Photocatalytic Treatment of Dyes with Ag Nanoparticles Obtained through Sustainable Process Involving Spirulina platensis Open

Agnieszka Sidorowicz, Giacomo Fais, Francesco Desogus, Francesco Loy, Roberta Licheri , et al. · 2024

The development of efficient photocatalysts is crucial in addressing water pollution concerns, specifically in the removal of organic dyes from wastewater. In this context, the use of silver nanoparticles (Ag NPs) might represent a method …

Optimization of Brilliant Blue R photocatalytic degradation by silver nanoparticles synthesized using Chlorella vulgaris Open

Agnieszka Sidorowicz, Giacomo Fais, Francesco Desogus, Francesco Loy, Roberta Licheri , et al. · 2024

Osmotic injury and cytotoxicity for hMSCs in contact with Me2SO: The effect of cell size distribution Open

Gabriele Traversari, Antonio Mario Locci, Alessandro Concas, Nicola Lai, Alberto Cincotti · 2024

Estimation of differential pathlength factor from NIRS measurement in skeletal muscle Open

Bhabuk Koirala, Alessandro Concas, Alberto Cincotti, Yi Sun, A. Hernández , et al. · 2024

In-situ resource utilization to produce Haematococcus pluvialis biomass in simulated Martian environment Open

Mattia Casula, Pierluigi Caboni, Giacomo Fais, Debora Dessì, Paola Scano , et al. · 2024

Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis Open

Krithika Ramachandran, Christopher R. Futtner, Meredith A. Sommars, Mattia Quattrocelli, Yasuhiro Omura , et al. · 2024

Estimation of Differential Pathlength Factor from Nirs Measurement in Skeletal Muscle Open

Bhabuk Koirala, Alessandro Concas, Alberto Cincotti, Yi Sun, Andrés Hernández , et al. · 2024

Teleosts as behaviour test models for social stress Open

Nicola Lai, Izzati Adriana Mohd Zahir, Anthony Kin Yip Liew, Satoshi Ogawa, Ishwar S. Parhar , et al. · 2023

Stress is an important aspect of our everyday life and exposure to it is an unavoidable occurrence. In humans, this can come in the form of social stress or physical stress from an injury. Studies in animal models have helped researchers t…

Recent advances on ISRU technologies and study of microgravity impact on blood cells for deep space exploration Open

Giacomo Cao, Alessandro Concas, Roberto Orrù, Roberta Licheri, Elisa Sani , et al. · 2023

The long-term solution to problems like overcrowding, fossil fuel depletion, climate change, and decreasing natural resource availability could be overcome through space colonization and human presence in space, as well as the exploitation…

Nanoparticles from Microalgae and Their Biomedical Applications Open

Agnieszka Sidorowicz, Giacomo Fais, Mattia Casula, Massimiliano Borselli, Giuseppe Giannaccare , et al. · 2023

Over the years, microalgae have been a source of useful compounds mainly used as food and dietary supplements. Recently, microalgae have been used as a source of metabolites that can participate in the synthesis of several nanoparticles th…

Relationship between muscle venous blood oxygenation and near-infrared spectroscopy: quantitative analysis of the Hb and Mb contributions Open

Bhabuk Koirala, Alessandro Concas, Yi Sun, L. Bruce Gladden, Nicola Lai · 2023

Within the near-infrared spectroscopy (NIRS) signal, the contribution from hemoglobin is indistinguishable from that of myoglobin. A computation analysis indicates that a linear relationship between muscle venous oxygen content and NIRS si…

Modeling and experimental assessment of Synechococcus nidulans cultivation using simulated Martian medium and astronauts’ urine Open

Alessandro Concas, Giacomo Fais, Marco Enna, Susanna Zucchelli, Pierluigi Caboni , et al. · 2023

The growth of microalgae as food for astronauts is one of the main challenges in view of future manned missions on Mars. The possibility of cultivating the cyanobacterium Synechococcus nidulans in a medium consisting of a mixture of simula…

Data Supporting Nanosecond Pulsed Electric Fields Modulate Electron Transport in in the Plasma Membrane and Mitochondria Open

Kamal Asadipour, Lucas Potter, Maisoun Bani Hani, Nicola Lai, Stephen J. Beebe · 2023

The production of OH in a nanosecond pulsed helium plasma jet impinging on water, saline, or pigskin Open

Meimei Lai, Shutong Song, Edwin A. Oshin, Lucas Potter, Nicola Lai , et al. · 2022

Applications of plasma-induced biological effects via reactive oxygen and nitrogen species (RONS) make the non-thermal atmospheric-pressure plasma jets an appealing tool in biomedical fields. The presence of biological materials, especiall…

Blood volume versus deoxygenated NIRS signal: computational analysis of the effects muscle O<sub>2</sub> delivery and blood volume on the NIRS signals Open

Bhabuk Koirala, Alessandro Concas, Yi Sun, L. Bruce Gladden, Nicola Lai · 2021

Deoxygenated is preferred to the oxygenated near-infrared spectroscopy signal in evaluating skeletal muscle oxygen extraction because it is assumed to be insensitive to blood volume changes. The quantitative analysis proposed in this study…

Relating cardiorespiratory responses to work rate during incremental ramp exercise on treadmill in children and adolescents: sex and age differences Open

Nicola Lai, Justin J. Fiutem, Nora Pfaff, Desy Salvadego, James Strainic · 2021

Cyclophilin D Is a Sensor of Nano-Pulse Stimulation Open

Brittney L. Ruedlinger, Bani Hani Maisoun, Lucas Potter, Nicola Lai, Stephen J. Beebe · 2021

Nano-Pulse Stimulation (NPS), a pulsed power-derived technology, stimulates structural and functional changes in plasma membranes and cellular organelles. NPS induces a Ca2+ influx and opening of the mitochondrial permeability transition p…

Mechanochemical Treatment of Soils Contaminated by Heavy Metals in Attritor and Impact Mills: Experiments and Modeling Open

Alessandro Concas, Selena Montinaro, Massimo Pisu, Nicola Lai, Giacomo Cao · 2021

An integrative approach was developed to support the scale-up from lab-into pilot-scale mechano-chemical reactors for immobilize heavy metals in contaminated mining soil.

Cellular vulnerability in Lewy body diseases Open

Daniel Erskine, Chris Hatton, Abigail Perrott, Nicola Lai, Keval Sidhpura , et al. · 2020

Background Lewy body diseases (LBD) are characterised by Lewy body pathology, cell loss and mitochondrial dysfunction, but the overlap between these three features is not well understood. We have explored the hypothesis that neurodegenerat…

Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki) Open

Nicola Lai, Ciarán E. Fealy, Chinna Kummitha, Silvia Cabras, John P. Kirwan , et al. · 2020

With competing fuels, the presence of fatty acids diminishes mitochondria ability to utilize carbohydrate derived substrates in insulin-resistant muscle despite reduced PPARδ content.

Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture Open

Jing Yuan, Congxin Huang, Nicola Lai, Li Z, Xuejun Jiang , et al. · 2020

Jinlong Yuan,1,* Chenlei Huang,2,* Niansheng Lai,1 Zhenbao Li,1 Xiaochun Jiang,1 Xuanzhi Wang,1 Xintong Zhao,1 Degang Wu,1 Jiaqiang Liu,1 Dayong Xia,1 Xinggen Fang1 1Department of Neurosurgery, The First Affiliated Hospital of Wannan Medic…

Bioenergetic functions in subpopulations of heart mitochondria are preserved in a non-obese type 2 diabetes rat model (Goto-Kakizaki) Open

Nicola Lai, Chinna Kummitha, Francesco Loy, Raffaella Isola, Charles L. Hoppel · 2020

Integrated approach for data acquisition, visualization and processing of analog polarographic systems for bioenergetics studies Open

Lisa Potter, Dean J. Krusienski, Janet Kennedy, Hoppel Cl, Nicola Lai · 2019

Alterations of skeletal muscle bioenergetics in a mouse with F508del mutation leading to a cystic fibrosis-like condition Open

Nicola Lai, Chinna Kummitha, Mitchell L. Drumm, Charles L. Hoppel · 2019

High energy expenditure is reported in cystic fibrosis (CF) animal models and patients. Alterations in skeletal muscle oxidative capacity, fuel utilization, and the creatine kinase-phosphocreatine system suggest mitochondrial dysfunction. …

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