Nicolae Done
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View article: SAT-696 A Comparison of Tirzepatide vs Semaglutide for Weight Reduction over 6 Months of Treatment in Adults with Obesity in US Clinical Practice Settings
SAT-696 A Comparison of Tirzepatide vs Semaglutide for Weight Reduction over 6 Months of Treatment in Adults with Obesity in US Clinical Practice Settings Open
Disclosure: C. Le Roux: Novo Nordisk, Roche Pharmaceuticals, Eli Lilly & Company, Johnson &Johnson, Boehringer Ingelheim, AstraZeneca, Amgen Inc, Abbvie, Herbalife, GI Dynamics, Gila, Irish Life Health, Currax, Zealand Pharma, Keyron, Arro…
View article: Healthcare resource use and costs among patients with COVID-19 in the United States
Healthcare resource use and costs among patients with COVID-19 in the United States Open
During the first four months of the Omicron wave, the economic burden of COVID-19 remained substantial. Older age and co-morbidities were associated with higher HCRU and treatment costs. This study provides data for future research evaluat…
View article: Predicting trajectories of the north star ambulatory assessment total score in Duchenne muscular dystrophy
Predicting trajectories of the north star ambulatory assessment total score in Duchenne muscular dystrophy Open
The North Star Ambulatory Assessment (NSAA) is a widely used functional endpoint in drug development for ambulatory patients with Duchenne muscular dystrophy (DMD). Accurately predicting NSAA total score trajectories is important for desig…
View article: Temporal trends in vaccination and antibiotic use among young children in the United States, 2000–2019
Temporal trends in vaccination and antibiotic use among young children in the United States, 2000–2019 Open
Objective: Routine immunization programs may reduce antibiotic use, but few studies have comprehensively examined their impact on antibiotic utilization. We aimed to explore temporal trends in vaccination and antibiotic use among young chi…
View article: Meaningful changes in motor function in Duchenne muscular dystrophy (DMD): A multi-center study
Meaningful changes in motor function in Duchenne muscular dystrophy (DMD): A multi-center study Open
Evaluations of treatment efficacy in Duchenne muscular dystrophy (DMD), a rare genetic disease that results in progressive muscle wasting, require an understanding of the ‘meaningfulness’ of changes in functional measures. We estimated the…
View article: Pathway for Development and Validation of Multi-domain Endpoints for Amyloid Light Chain (AL) Amyloidosis
Pathway for Development and Validation of Multi-domain Endpoints for Amyloid Light Chain (AL) Amyloidosis Open
Immunoglobin light chain (AL) amyloidosis is a rare disease in which a plasma cell dyscrasia leads to deposition of insoluble amyloid fibrils in multiple organs. To facilitate development of new therapies for this heterogenous disease, a p…
View article: Survival among patients receiving eteplirsen for up to 8 years for the treatment of <scp>Duchenne</scp> muscular dystrophy and contextualization with natural history controls
Survival among patients receiving eteplirsen for up to 8 years for the treatment of <span>Duchenne</span> muscular dystrophy and contextualization with natural history controls Open
Introduction/Aims Eteplirsen, approved in the US for patients with Duchenne muscular dystrophy (DMD) with exon 51 skip‐amenable variants, is associated with attenuated ambulatory/pulmonary decline versus DMD natural history (NH). We report…
View article: Potential Implications of Slowing Disease Progression in Amyloid-Positive Early Alzheimer's Disease: Estimates from Real-World Data
Potential Implications of Slowing Disease Progression in Amyloid-Positive Early Alzheimer's Disease: Estimates from Real-World Data Open
Slowing early AD progression could result in preservation of functional and behavioral attributes and functional autonomy for longer.
View article: Impact of Differential Rates of Disease Progression in Amyloid-Positive Early Alzheimer's Disease: Findings from a Longitudinal Cohort Analysis
Impact of Differential Rates of Disease Progression in Amyloid-Positive Early Alzheimer's Disease: Findings from a Longitudinal Cohort Analysis Open
Despite similar demographic and clinical profiles at baseline, amyloid-positive individuals with greater deterioration based on CDR-SB early in the AD trajectory continue to experience worse functional and behavioral outcomes over time tha…
View article: 534. Healthcare Resource Utilization and Costs among Patients with COVID-19 in the United States
534. Healthcare Resource Utilization and Costs among Patients with COVID-19 in the United States Open
Background COVID-19 continued to cause significant burden on the healthcare system even during the less severe Omicron wave. We evaluated outpatient and inpatient healthcare resource use (HCRU) and costs among adults with COVID-19 in the U…
View article: 1693. Incidence of Pneumococcal Disease in Children ≤48 Months Old in the United States: 2010-2019
1693. Incidence of Pneumococcal Disease in Children ≤48 Months Old in the United States: 2010-2019 Open
Background Pneumococcal disease (PD) leads to considerable morbidity, mortality, and healthcare resource utilization in children. This study estimated incidence rates (IRs) for invasive PD (IPD), all-cause pneumonia (ACP), and acute otitis…
View article: Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis
Real-World Treatment Patterns among Patients with Alopecia Areata in the USA: A Retrospective Claims Analysis Open
Alopecia areata is an autoimmune disorder characterized by hair loss, for which there are few treatment options. This claims-based study characterized recent real-world treatment patterns among patients in the USA with alopecia areata, inc…
View article: Economic burden of acute otitis media, pneumonia, and invasive pneumococcal disease in children in the United States after the introduction of 13-valent pneumococcal conjugate vaccines during 2014–2018
Economic burden of acute otitis media, pneumonia, and invasive pneumococcal disease in children in the United States after the introduction of 13-valent pneumococcal conjugate vaccines during 2014–2018 Open
Background Streptococcus pneumoniae remains a leading cause of morbidity, mortality, and healthcare resource utilization (HRU) among children. This study quantified HRU and cost of acute otitis media (AOM), pneumonia, and invasive pneumoco…
View article: Incidence of non-invasive all-cause pneumonia in children in the United States before and after the introduction of pneumococcal conjugate vaccines: a retrospective claims database analysis
Incidence of non-invasive all-cause pneumonia in children in the United States before and after the introduction of pneumococcal conjugate vaccines: a retrospective claims database analysis Open
View article: Patient characteristics associated with all-cause healthcare costs of alopecia areata in the United States
Patient characteristics associated with all-cause healthcare costs of alopecia areata in the United States Open
Evidence on the factors of medical costs involved in the care of people with alopecia areata (AA) is limited, but mounting evidence points to significant variation in financial impact for patients with AA in the absence of effective treatm…
View article: Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population
Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population Open
Importance Alopecia areata (AA) is characterized by nonscarring hair loss of the scalp, face, and/or body. Alopecia totalis (AT) and alopecia universalis (AU) involve complete loss of the scalp and body hair, respectively. The epidemiology…
View article: P260: Survival in eteplirsen-treated vs Duchenne muscular dystrophy natural history patients: An indirect treatment comparison using real-world data
P260: Survival in eteplirsen-treated vs Duchenne muscular dystrophy natural history patients: An indirect treatment comparison using real-world data Open
View article: Incidence of invasive pneumococcal disease in children with commercial insurance or Medicaid coverage in the United States before and after the introduction of 7- and 13-valent pneumococcal conjugate vaccines during 1998–2018
Incidence of invasive pneumococcal disease in children with commercial insurance or Medicaid coverage in the United States before and after the introduction of 7- and 13-valent pneumococcal conjugate vaccines during 1998–2018 Open
Background Invasive pneumococcal disease (IPD) is a major cause of pediatric morbidity and mortality. Pneumococcal conjugate vaccines (PCVs) were introduced in the US in 2000 (PCV7) and 2010 (PCV13). This study estimated the annual inciden…
View article: Healthcare Utilization and Costs Among US Adolescents With Alopecia Areata
Healthcare Utilization and Costs Among US Adolescents With Alopecia Areata Open
Background Alopecia areata (AA) is an autoimmune disease of hair loss affecting people of all ages. Alopecia totalis (AT) and universalis (AU) involve scalp and total body hair loss, respectively. AA significantly affects quality of life, …
View article: Chronic Myeloid Leukemia: Part I—Real-World Treatment Patterns, Healthcare Resource Utilization, and Associated Costs in Later Lines of Therapy in the United States
Chronic Myeloid Leukemia: Part I—Real-World Treatment Patterns, Healthcare Resource Utilization, and Associated Costs in Later Lines of Therapy in the United States Open
Background: Alopecia areata (AA) is an autoimmune disease of hair loss affecting people of all ages. Alopecia totalis (AT) and universalis (AU) involve scalp and total body hair loss, respectively. AA significantly affects quality of life,…
View article: Incidence of acute otitis media in children in the United States before and after the introduction of 7- and 13-valent pneumococcal conjugate vaccines during 1998–2018
Incidence of acute otitis media in children in the United States before and after the introduction of 7- and 13-valent pneumococcal conjugate vaccines during 1998–2018 Open
View article: All-cause health care resource utilization and costs among adults with alopecia areata: A retrospective claims database study in the United States
All-cause health care resource utilization and costs among adults with alopecia areata: A retrospective claims database study in the United States Open
BACKGROUND: Alopecia areata (AA) is an autoimmune disorder characterized by hair loss. Patients may present with hair loss of the scalp, eyelashes, eyebrows, and/or body. Alopecia totalis (AT), total scalp hair loss, or alopecia uni…
View article: Real-world and natural history data for drug evaluation in Duchenne muscular dystrophy: suitability of the North Star Ambulatory Assessment for comparisons with external controls
Real-world and natural history data for drug evaluation in Duchenne muscular dystrophy: suitability of the North Star Ambulatory Assessment for comparisons with external controls Open
View article: Comparing total medical expenditure between patients receiving direct oral anticoagulants vs warfarin for the treatment of atrial fibrillation: evidence from VA-Medicare dual enrollees
Comparing total medical expenditure between patients receiving direct oral anticoagulants vs warfarin for the treatment of atrial fibrillation: evidence from VA-Medicare dual enrollees Open
BACKGROUND: Direct oral anticoagulants (DOACs) are an alternative to warfarin for treatment of atrial fibrillation (AF). Evidence demonstrating the efficacy and safety of DOACs has primarily been from clinical trial settings. The re…
View article: Deterioration of Health-Related Quality of Life After Withdrawal of Risankizumab Treatment in Patients with Moderate-to-Severe Plaque Psoriasis: A Machine Learning Predictive Model
Deterioration of Health-Related Quality of Life After Withdrawal of Risankizumab Treatment in Patients with Moderate-to-Severe Plaque Psoriasis: A Machine Learning Predictive Model Open
View article: DLQI Prediction in Psoriasis
DLQI Prediction in Psoriasis Open
Supplementary Appendix for "Deterioration of health-related quality of life after withdrawal of risankizumab treatment in patients with moderate to severe plaque psoriasis: a machine learning predictive model"
View article: 1480. Incidence of Non-Invasive Pneumococcal Pneumonia in Children in the United States before and after Introduction Pneumococcal Conjugate Vaccines (PCV7 and PCV13) during 1998-2018
1480. Incidence of Non-Invasive Pneumococcal Pneumonia in Children in the United States before and after Introduction Pneumococcal Conjugate Vaccines (PCV7 and PCV13) during 1998-2018 Open
Background Pneumonia causes significant pediatric morbidity, mortality, and healthcare resource utilization. S. pneumoniae is a leading cause of bacterial pneumonia in children. Merck is developing V114, an investigational 15-valent PCV th…
View article: 1479. Incidence of Acute Otitis Media in Children in the United States before and after the introduction of Pneumococcal Conjugate Vaccines (PCV7 and PCV13) during 1998-2018
1479. Incidence of Acute Otitis Media in Children in the United States before and after the introduction of Pneumococcal Conjugate Vaccines (PCV7 and PCV13) during 1998-2018 Open
Background Acute otitis media (AOM) leads to considerable healthcare resource utilization in children. Streptococcus pneumoniae is an important cause of AOM. Merck is developing V114, an investigational 15-valent PCV that contains PCV13 se…
View article: Comparing Total Medical Costs between Patients Receiving Direct Oral Anticoagulants Versus Warfarin for the Treatment of Atrial Fibrillation: Evidence from the VA
Comparing Total Medical Costs between Patients Receiving Direct Oral Anticoagulants Versus Warfarin for the Treatment of Atrial Fibrillation: Evidence from the VA Open
Atrial fibrillation (AFib) is the second most common cardiovascular condition affecting up to 6.1 million individuals in the United States. Treatment of AFib focuses on preventing blood clots to reduce stroke risk. Traditionally, warfarin,…
View article: The Relationship Between Follow-up Appointments and Access to Primary Care
The Relationship Between Follow-up Appointments and Access to Primary Care Open