Nicolas Baeyens
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View article: Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis
Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis Open
Dental pulp responses to dental decay, the most prevalent chronic disease worldwide, involve remodeling processes comparable to those observed in other human diseases. By combining volumetric imaging and single‐cell analysis at various sta…
View article: Optimizing Tissue Clearing Protocols for Whole-Organoid Imaging of Human Cortical and Retinal iPSC-Derived Models
Optimizing Tissue Clearing Protocols for Whole-Organoid Imaging of Human Cortical and Retinal iPSC-Derived Models Open
Background: Three-dimensional brain organoids derived from human induced pluripotent stem cells provide valuable in vitro systems for studying human brain development and neurological disorders. However, their dense and heterogeneous struc…
View article: Volumetric imaging and single-cell RNAseq atlases identify cellular mechanisms of human dental pulp response during tooth decay progression
Volumetric imaging and single-cell RNAseq atlases identify cellular mechanisms of human dental pulp response during tooth decay progression Open
Dental pulp responses to dental decay, the most prevalent chronic disease worldwide, involve remodeling processes similar to those observed in other human pathological conditions. By integrating volumetric imaging and single-cell analysis …
View article: Effect of Surface Modification of Gold Nanoparticles Loaded with Small Nucleic Acid Sequences on Cytotoxicity and Uptake: A Comparative Study In Vitro
Effect of Surface Modification of Gold Nanoparticles Loaded with Small Nucleic Acid Sequences on Cytotoxicity and Uptake: A Comparative Study In Vitro Open
Nanoparticle technology, particularly gold nanoparticles (AuNPs), is being developed for a wide range of applications, including as a delivery system of peptides or nucleic acids (NA). Their use in precision medicine requires detailed engi…
View article: Editorial: Mechanotransduction in vascular development and disease
Editorial: Mechanotransduction in vascular development and disease Open
SCOPUS: ed.j
View article: Reversal of vein of Galen aneurysmal malformation by stimulation of flow-mediated vessel fusion
Reversal of vein of Galen aneurysmal malformation by stimulation of flow-mediated vessel fusion Open
Congenital vascular malformations arise from defective homeostatic development of the vascular tree 1 . The aneurysmal malformation of the Vein of Galen (VGAM) is the most frequent neurovascular malformation in neonates, with limited thera…
View article: HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes
HAMSAB diet ameliorates dysfunctional signaling in pancreatic islets in autoimmune diabetes Open
An altered gut microbiota is associated with type 1 diabetes (T1D), affecting the production of short-chain fatty acids (SCFA) and glucose homeostasis. We previously demonstrated that enhancing serum acetate and butyrate using a dietary su…
View article: Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization
Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization Open
Chemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhi…
View article: Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling
Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling Open
Significance This paper analyzes the signaling network that regulates the size of artery lumens and thus their ability to transport blood to tissues. Lumen diameter is under close homeostatic regulation to match artery flow to the needs of…
View article: Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling
Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling Open
Rationale Blood vessel remodeling in response to changes in tissue demand is an important aspect of fitness and is often compromised in vascular disease. Endothelial cell (EC) sensing of fluid shear stress (FSS) governs vessel remodeling t…
View article: microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis Open
Summary The mechanical properties of tissues, which are determined primarily by their extracellular matrix (ECM), are largely stable over time despite continual turnover of ECM constituents 1,2 . These observations imply active homeostasis…
View article: Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development
Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development Open
The role of fluid shear stress in vasculature development and remodeling is well appreciated. However, the mechanisms regulating these effects remain elusive. We show that abnormal flow sensing in lymphatic endothelial cells (LECs) caused …
View article: Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia Open
Morphogenesis of the vascular system is strongly modulated by mechanical forces from blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal-dominant disease in which arteriovenous malformations and telangiectasia…
View article: Endothelial fluid shear stress sensing in vascular health and disease
Endothelial fluid shear stress sensing in vascular health and disease Open
Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into biochemical signals that regulate gene expression and cell behavior via specialized mechanisms and pathways. These pathways shape the vascular syste…