Explanipedia

Shiga Toxin–Producing Escherichia coli–Associated Hemolytic Uremic Syndrome in Adult Kidney Transplant Recipients Open

Manal Mazloum, P. Trémolières, Nesrine Baili, Cédric Rafat, Hannah Kaminski , et al. · 2025

Impact of SGLT2 inhibitors on blood pressure among kidney transplant recipients: insights from a French multicentric cohort (GREAT ASTRE) Open

Lucile Baslé, Lucie Maigret, Vincent Dupont, Loïc Lièvre, Nicolas Bouvier , et al. · 2025

In KTRs newly treated with SGLT2i, BP decreased at 3 and 6 months, while the overall antihypertensive load, as assessed by DDD, remained stable. Similar effects were observed on HTi. These findings suggest SGLT2i as an effective adjunctive…

Biopsy-Proven T-Cell Mediated Rejection After Belatacept Rescue Conversion: A Multicenter Retrospective Study Open

Dominique Bertrand, Nathalie Chavarot, Jérôme Olagne, Clarisse Grèze, Philippe Gatault , et al. · 2024

After kidney transplantation, conversion to belatacept is a promising alternative in patients with poor graft function or intolerance to calcineurin inhibitors. The risk of acute rejection has not been well described under these conditions…

Impact of Switching From Immediate- or Prolonged-Release to Once-Daily Extended-Release Tacrolimus (LCPT) on Tremor in Stable Kidney Transplant Recipients: The Observational ELIT Study Open

Magali Giral, Philippe Grimbert, Baptiste Morin, Nicolas Bouvier, Matthias Büchler , et al. · 2024

Once-daily extended-release tacrolimus (LCPT) exhibits increased bioavailability versus immediate-release (IR-TAC) and prolonged release (PR-TAC) tacrolimus. Improvements in tremor were previously reported in a limited number of kidney tra…

(1-3)-ß-D-glucan for the diagnosis of Nocardia infection in solid organ transplant recipients Open

Margot Paumier, Julien Coussement, Marie Matignon, Cécile Chauvet, Nicolas Bouvier , et al. · 2024

Torque teno virus viremia and QuantiFERON®-CMV assay in prediction of cytomegalovirus reactivation in R+ kidney transplant recipients Open

Sarah Mafi, Marie Essig, Jean-Philippe Rérolle, Gisèle Lagathu, Romain Crochette , et al. · 2023

Introduction Cytomegalovirus (CMV) is the most frequent infectious complication following solid organ transplantation. Torque teno viruses (TTV) viremia has been proposed as a biomarker of functional immunity in the management of kidney tr…

Absence of Mortality Differences Between the First and Second COVID-19 Waves in Kidney Transplant Recipients Open

Bastien Berger, Marc Hazzan, Nassim Kamar, H. François, Marie Matignon , et al. · 2022

Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France Open

Laurène Tardieu, Gillian Divard, Olivier Lortholary, Anne Scemla, Éric Rondeau , et al. · 2022

Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well as its clinical features and radiological…

Impact of targeted hypothermia in expanded-criteria organ donors on recipient kidney-graft function: study protocol for a multicentre randomised controlled trial (HYPOREME) Open

N. Brulé, Emmanuel Canet, Morgane Péré, Fanny Feuillet, Maryvonne Hourmant , et al. · 2022

Introduction Expanded-criteria donors (ECDs) are used to reduce the shortage of kidneys for transplantation. However, kidneys from ECDs are associated with an increased risk of delayed graft function (DGF), a risk factor for allograft loss…

Changing of therapeutic trends between the 1st and 2nd wave did not reduce COVID-19 related mortality of renal transplant recipients: a national registry study Open

Bastien Berger, Marc Hazzan, Nassim Kamar, H. François, Marie Matignon , et al. · 2021

SARS-CoV-2 pandemic evolved in two consecutive waves over 2020 (for France: 1st wave from March 1 to July 31; and 2nd wave from August 1 to December 31). Improvements in the management of COVID-19 led to a reduction of mortality rates in h…

Clinical Utility of Biochemical Markers for the Prediction of COVID-19−Related Mortality in Kidney Transplant Recipients Open

Nathalie Chavarot, Luc Frimat, Pierre François Westeel, Mariam Jdidou, Valentin Goutadier , et al. · 2021

Gross hematuria following SARS-CoV-2 vaccination in patients with IgA nephropathy Open

Peggy Perrin, Xavier Bassand, Iliès Benotmane, Nicolas Bouvier · 2021

Occurrence of severe COVID-19 in vaccinated transplant patients Open

Sophie Caillard, Nathalie Chavarot, Dominique Bertrand, Nassim Kamar, Olivier Thaunat , et al. · 2021

Intensity of de novo DSA detected by Immucor Lifecodes assay and C3d fixing antibodies are not predictive of subclinical ABMR after Kidney Transplantation Open

Dominique Bertrand, Rangolie Kaveri, Charlotte Laurent, Philippe Gatault, Maïté Jaureguy , et al. · 2021

De novo donor-specific antibodies (dnDSA) are associated with antibody-mediated rejection (ABMR) and allograft loss. We tested Immucor* (IM) Luminex Single-antigen beads (LSAB) assay and C3d-fixing antibodies in the setting of dnDSA and su…

Living kidney donor evaluation for all candidates with normal estimated GFR for age Open

F. Gaillard, Lola Jacquemont, Hélène Lazareth, Laetitia Albano, Benoı̂t Barrou , et al. · 2021

Multiple days assessments are frequent for the evaluation of candidates to living kidney donation, combined with an early GFR estimation (eGFR). Living kidney donation is questionable when eGFR is 2 (KDIGO guidelines) or 80 ml/min/1.…

Sexual Dysfunction Improvement after Kidney Transplantation: A Prospective Study in Men and Women Open

Mélanie Laguerre, Nicolas Bouvier, K. Guleryuz, A. Doerfler, Jean‐Jacques Parienti , et al. · 2020

Our study provides evidence suggesting that successful transplantation can improve normal sexual function in both men and women with chronic kidney failure.

Paternity in male kidney transplant recipients: a French national survey, the PATeRNAL study Open

Annabel Boyer, T. Lobbedez, Mohamed Ouethrani, A. Lecouf, Nicolas Bouvier , et al. · 2020

IMPact of the COVID-19 epidemic on the moRTAlity of kidney transplant recipients and candidates in a French Nationwide registry sTudy (IMPORTANT) Open

Olivier Thaunat, Camille Legeai, Dany Anglicheau, Lionel Couzi, Gilles Blancho , et al. · 2020

Opportunistic Infections and Efficacy Following Conversion to Belatacept-Based Therapy after Kidney Transplantation: A French Multicenter Cohort Open

Dominique Bertrand, Florian Terrec, Isabelle Étienne, Nathalie Chavarot, Rebecca Sberro , et al. · 2020

Conversion from calcineurin-inhibitors (CNIs) to belatacept can help kidney-transplant (KT) recipients avoid CNI-related nephrotoxicity. The risk of associated opportunistic infections (OPIs) is ill-defined. We conducted a multicentric coh…

Paternity in male kidney transplant recipients: A French national survey, the PATeRNAL study. Open

Annabel Boyer, Thierry Lobbedez, Mohamed Ouethrani, A. Lecouf, Nicolas Bouvier , et al. · 2020

Background : There is concern about the impact of immunosuppressive agents taken by male kidney transplant (KT) recipients on the risk of foetal malformations. The aim of our survey was to estimate the paternity rate and the outcomes of pr…

Paternity in male kidney transplant recipients: A French national survey, the PATeRNAL study. Open

Annabel Boyer, Thierry Lobbedez, Mohamed Ouethrani, A. Lecouf, Nicolas Bouvier , et al. · 2020

Background : There is concern about the impact of immunosuppressive agents taken by male kidney transplant (KT) recipients on the risk of foetal malformations. The aim of our survey was to estimate the paternity rate and the outcomes of pr…

Autoantibodies against granulocyte macrophage colony‐stimulating factor and <i>Nocardia</i> infection in solid organ transplant recipients Open

David Lebeaux, Julien Coussement, Cécile Chauvet, Marie Matignon, Anne Scemla , et al. · 2020

Dear Editors, Nocardiosis is a rare but potentially severe bacterial opportunistic infection that may occur after solid organ transplantation (SOT), typically among thoracic transplant recipients and/or in recipients with a high degree of …

An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants Open

Sophie Caillard, Dany Anglicheau, Marie Matignon, Antoine Dürrbach, Clarisse Grèze , et al. · 2020

The FcγRIIIA‐158 VV genotype increased the risk of post‐transplant lymphoproliferative disorder in T‐cell‐depleted kidney transplant recipients – a retrospective study Open

Philippe Gatault, Laurie Lajoie, Jana Stojanova, Jean‐Michel Halimi, Sophie Caillard , et al. · 2020

Post-transplantation lymphoproliferative disorder (PTLD) is a severe complication in organ transplant recipients. The use of T lymphocyte-depleting antibodies (TLDAb), especially rabbit TLDAb, contributes to PTLD, and the V158F polymorphis…

Protocol Biopsies in Patients With Subclinical De Novo Donor-specific Antibodies After Kidney Transplantation: A Multicentric Study Open

Dominique Bertrand, Philippe Gatault, Maïté Jaureguy, Cyril Garrouste, Johnny Sayegh , et al. · 2019

Background. De novo donor-specific antibodies (DSAs) are associated with antibody-mediated rejection (AMR) and allograft loss. Whether monitoring of de novo DSA (dnDSA) paired with systematic kidney biopsy should become routine remains to …

Diagnosis and management of asymptomatic bacteriuria in kidney transplant recipients: a survey of current practice in Europe Open

Julien Coussement, Umberto Maggiore, Oriol Manuel, Anne Scemla, Francisco López‐Medrano , et al. · 2018

Screening for and treating asymptomatic bacteriuria are common in KTRs despite uncertainties around the benefits and harms. In an era of antimicrobial resistance, further studies are needed to address the diagnosis and management of asympt…

Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study Open

David Lebeaux, R. Freund, Christian van Delden, Hélène Guillot, Sierk Marbus , et al. · 2017

Summary In our study of 117 organ transplant recipients with nocardiosis, a history of tumor, invasive fungal infection, donor age, and no acute rejection were independently associated with 1-year mortality. Short-course antibiotic treatme…

Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study Open

Philippe Gatault, Nassim Kamar, M. Büchler, Claudio Colosio, Dominique Bertrand , et al. · 2016

The aim of this study (ClinicalTrials.gov, NCT01744470) was to determine the efficacy and safety of two different doses of extended-release tacrolimus (TacER) in kidney transplant recipients (KTRs) between 4 and 12 mo after transplantation…

Anti-TNFα therapy for chronic inflammatory disease in kidney transplant recipients Open

Cyril Garrouste, Dany Anglicheau, Nassim Kamar, Claire Bachelier, Joseph Rivalan , et al. · 2016

Anti-tumor necrosis factor-α (TNFα) therapy has improved the prognosis of many chronic inflammatory diseases. It appears to be well-tolerated by liver-transplant patients. However, their use and their safety in kidney-transplant patients h…

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