Nicolas Buisine
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View article: Données issues d’ADN environnemental (ADNe) : Recommandations pour les partager, les stocker et les diffuser
Données issues d’ADN environnemental (ADNe) : Recommandations pour les partager, les stocker et les diffuser Open
Données issues d’ADN environnemental (ADNe) : Recommandations pour les partager, les stocker et les diffuser. Ce document s’adresse aux producteurs de données français utilisant l’ADN environnemental (ADNe). Son objectif est de fournir de …
View article: Overlapping action of T3 and T4 during Xenopus laevis development
Overlapping action of T3 and T4 during Xenopus laevis development Open
Thyroid hormones are involved in many biological processes such as neurogenesis, metabolism, and development. However, compounds called endocrine disruptors can alter thyroid hormone signaling and induce unwanted effects on human and ecosy…
View article: Transcriptional activation of candidate paused genes after partial hepatectomy
Transcriptional activation of candidate paused genes after partial hepatectomy Open
Partial hepatectomy is a model of acute liver injury that is known to induce a strong reprogrammation of gene expression. Transcriptional induction of Immediate Early Genes is extremely fast and this would be due to the release of RNA Poly…
View article: Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs
Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs Open
View article: Cross-Validation of Conserved Osteoblast-Specific Enhancers Illuminates Bone Diseases and Early Skeletal Evolution
Cross-Validation of Conserved Osteoblast-Specific Enhancers Illuminates Bone Diseases and Early Skeletal Evolution Open
View article: Differential effects of 3,5-T2 and T3 on the gill regeneration and metamorphosis of the Ambystoma mexicanum (axolotl)
Differential effects of 3,5-T2 and T3 on the gill regeneration and metamorphosis of the Ambystoma mexicanum (axolotl) Open
Thyroid hormones (THs) regulate tissue remodeling processes during early- and post-embryonic stages in vertebrates. The Mexican axolotl ( Ambystoma mexicanum ) is a neotenic species that has lost the ability to undergo metamorphosis; howev…
View article: Figure S3 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Figure S3 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Effects of MSC mitochondria on GSCs metabolic response to TMZ (A, B) GSC mitochondrial mass and ROS production. FACS analysis of MitoTracker and MitoSox-labeled GSCs after the acquisition of MSC mitochondria and TMZ treatment (24 hr). (A) …
View article: Figure S1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Figure S1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Experimental design and timeline
View article: FIGURE 1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Exchange of mitochondria between MSCs with GSCs enhances GSC energy metabolism and proliferation. A and B, Mitochondria exchange during coculture of MSCs and GSCs, respectively prelabeled with red MitoTracker and green CellTr…
View article: FIGURE 5 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 5 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
MSC mitochondria modify metabolite fluxes in GSCs. [U-13C]-glucose and [U-13C]-glutamine isotope profiling of GSCs with and/or without MSC mitochondria and treated or not with TMZ (48 hours; n = 3). A…
View article: Figure S3 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Figure S3 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Effects of MSC mitochondria on GSCs metabolic response to TMZ (A, B) GSC mitochondrial mass and ROS production. FACS analysis of MitoTracker and MitoSox-labeled GSCs after the acquisition of MSC mitochondria and TMZ treatment (24 hr). (A) …
View article: Figure S2 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Figure S2 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Quantification of mitochondrial DNA (mtDNA) following transfer of MSC mitochondria to GSCs (A) Detection of MSC mtDNA in GSCs. MSC mtDNA concentrations are expressed relative to GSC mtDNA. Mean with SEM, t test with Welch correction, *p < …
View article: Figure S2 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Figure S2 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Quantification of mitochondrial DNA (mtDNA) following transfer of MSC mitochondria to GSCs (A) Detection of MSC mtDNA in GSCs. MSC mtDNA concentrations are expressed relative to GSC mtDNA. Mean with SEM, t test with Welch correction, *p < …
View article: Video 1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Video 1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Cocultures of red MitoTracker-labeled MSCs and green CellTracker-labeled GSCs
View article: Supplementary Materials and Methods from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Supplementary Materials and Methods from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
TMZ dose-response assayCaspase-GloⓇ 3/7 assayCytotox assayExtracellular Flux AssaysCell ProliferationWestern BlotFlow CytometryMetabolite usage MitoplatesMass Spectrometry Quantification13C stable isotope tracing experimentsPreparation and…
View article: FIGURE 1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Exchange of mitochondria between MSCs with GSCs enhances GSC energy metabolism and proliferation. A and B, Mitochondria exchange during coculture of MSCs and GSCs, respectively prelabeled with red MitoTracker and green CellTr…
View article: Video 1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Video 1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Cocultures of red MitoTracker-labeled MSCs and green CellTracker-labeled GSCs
View article: FIGURE 6 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 6 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
MSC mitochondria induce a higher orotate turnover in GSCs which supports resistance to TMZ. A and B, [U-13C]-glucose and [U-13C]-glutamine orotate isotope profiling in GSCs with and/or without MSC mitoch…
View article: Figure S5 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Figure S5 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
MSC mitochondria modify the usage of metabolites by GCSs in response to TMZ CTRL Mito TMZ CTRL Mito Mito TMZ (A) Metabolic substrate consumption of GSCs expressed as metabolite initial consumption rates (Biolog MitoPlates). Mean values ± S…
View article: FIGURE 5 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 5 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
MSC mitochondria modify metabolite fluxes in GSCs. [U-13C]-glucose and [U-13C]-glutamine isotope profiling of GSCs with and/or without MSC mitochondria and treated or not with TMZ (48 hours; n = 3). A…
View article: Figure S5 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Figure S5 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
MSC mitochondria modify the usage of metabolites by GCSs in response to TMZ CTRL Mito TMZ CTRL Mito Mito TMZ (A) Metabolic substrate consumption of GSCs expressed as metabolite initial consumption rates (Biolog MitoPlates). Mean values ± S…
View article: FIGURE 7 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 7 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Metabolomics analysis of resected GBM from patients, pre- and post-TMZ treatment shows increased nucleotides concentrations. A, Metabolomics analysis were performed on GBM resected tumors from 8 patients, before treatment and after …
View article: Figure S6 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Figure S6 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Metabolite detection in resected GBM from 8 patients, at 1rst resection and at 2nd resection post-TMZ treatment. For each metabolite, the C12/C13 ratios normalized to tissue protein concentrations are indicated.
View article: FIGURE 7 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 7 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Metabolomics analysis of resected GBM from patients, pre- and post-TMZ treatment shows increased nucleotides concentrations. A, Metabolomics analysis were performed on GBM resected tumors from 8 patients, before treatment and after …
View article: FIGURE 4 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 4 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
MSC mitochondria modify GSC metabolite production in response to TMZ. GSC metabolites production was analyzed by mass spectrometry on whole-cell extracts. A, Heat map of metabolites produced by GSCs following acquisition of MSC mito…
View article: Figure S4 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Figure S4 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
Metabolites produced by GSCs following MSC mitochondria acquisition and TMZ treatment
View article: FIGURE 4 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 4 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
MSC mitochondria modify GSC metabolite production in response to TMZ. GSC metabolites production was analyzed by mass spectrometry on whole-cell extracts. A, Heat map of metabolites produced by GSCs following acquisition of MSC mito…
View article: FIGURE 6 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 6 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
MSC mitochondria induce a higher orotate turnover in GSCs which supports resistance to TMZ. A and B, [U-13C]-glucose and [U-13C]-glutamine orotate isotope profiling in GSCs with and/or without MSC mitoch…
View article: Supplementary Materials and Methods from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
Supplementary Materials and Methods from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
TMZ dose-response assayCaspase-GloⓇ 3/7 assayCytotox assayExtracellular Flux AssaysCell ProliferationWestern BlotFlow CytometryMetabolite usage MitoplatesMass Spectrometry Quantification13C stable isotope tracing experimentsPreparation and…
View article: FIGURE 2 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring
FIGURE 2 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring Open
MSC mitochondria increase GSC survival in response to TMZ. A and F, Time lines for the response of GSCs to TMZ, at day 5 (B–E) and at 48 hours (G–H). B, Survival of GSCs in response to TMZ (dose–response …