Explanipedia

AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression Open

Jean‐Christophe Corvol, Mickaël Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel , et al. · 2025

Objectives The aim was to evaluate the safety, tolerability, pharmacokinetics, and potential clinical efficacy of AZP2006, an oral pleiotropic drug modulating progranulin levels, in patients with progressive supranuclear palsy (PSP), a rar…

Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis Open

Aymeric Lanore, Christelle Tesson, Aymeric Basset, François-Xavier Lejeune, Guillaume Cogan , et al. · 2025

Brain atrophy patterns in anti-IgLON5 disease Open

Selina Yogeshwar, Frederik Bartels, Thomas Grüter, Sergio Muñiz‐Castrillo, Géraldine Picard , et al. · 2025

Anti-IgLON5 disease is an autoimmune encephalitis that presents with a heterogenous clinical phenotype, including sleep disorders, movement abnormalities and bulbar involvement. It is characterised by autoantibodies against IgLON5, 85% ass…

Neuropathy in GAA‐FGF14 Late‐Onset Cerebellar Ataxia (SCA27B): Prevalence and Characteristics Open

Julian Theuriet, Lukas Paulet, Blandine Acket, Fabienne Ory‐Magne, Hocine Belbachir , et al. · 2025

Background This study aimed to investigate the prevalence, characteristics, and determinants of peripheral neuropathy in a large cohort of patients affected by spinocerebellar ataxia type 27B (SCA27B), a late‐onset cerebellar ataxia caused…

Survey on Parkinson’s Disease Diagnosis Impact: Patients, Caregivers and Health Care Professionals’ Perspectives Open

Stela Dodaj, Margherita Fabbri, Anne Doé de Maindreville, Alexandra Foubert‐Samier, Marie-Claire Toussaint , et al. · 2024

Background: The announcement of Parkinson’s disease (PD) diagnosis may provoke negative feelings that impact the ability to cope with the disease and all life changes related to this new condition. There are scarce data on how to improve c…

Development of a Screening Tool for Assessing Sexual Difficulties Among Patients with Parkinson’s Disease: The PD-SDS Open

Clara De Groote, Kathy Dujardin, Luc Defebvre, Bérengère Flinois, Virginie Herlin , et al. · 2024

Background: People with Parkinson’s disease (PwPD) exhibit various sexual difficulties (SDs) that may be due to motor and/or nonmotor symptoms or the use of antiparkinsonian medication. SDs are often underreported by PwPD and underexplored…

Impact of biologically effective dose on tremor decrease after stereotactic radiosurgical thalamotomy for essential tremor: a retrospective longitudinal analysis Open

Constantin Tuleasca, Guillaume Carey, Romain Barriol, Gustavo Touzet, François Dubus , et al. · 2024

Stereotactic radiosurgery (SRS) is one of the surgical alternatives for drug-resistant essential tremor (ET). Here, we aimed at evaluating whether biologically effective dose (BED Gy2.47 ) is relevant for tremor improvement after stereotac…

A Double‐Blind, Randomized, Placebo‐Controlled Trial of Bumetanide in Parkinson's Disease Open

Philippe Damier, Bertrand Degos, Giovanni Castelonovo, Mathieu Anheim, Isabelle Bénatru , et al. · 2024

Background Acting on the main target of dopaminergic cells, the striatal γ‐aminobutyric acid (GABA)‐ergic cells, might be a new way to treat persons with Parkinson's disease (PD). Objective The objective of this study was to assess the eff…

AZP2006 in Progressive Supranuclear Palsy: A Multi-Centre, Randomized, Phase 2a Trial Assessing Safety and Biomarker Outcomes Open

Jean‐Christophe Corvol, Mickaël Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel , et al. · 2024

AZP2006 in Progressive Supranuclear Palsy: A Multi-Centre, Randomized, Phase 2a Trial Assessing Safety and Biomarker Outcomes Open

Jean‐Christophe Corvol, Mickaël Alexandre Obadia, Jean‐Philippe Brandel, Sara Sambin, Nicolas Carrière , et al. · 2024

The Use of Image Guided Programming to Improve Deep Brain Stimulation Workflows with Directional Leads in Parkinson’s Disease Open

Anne‐Sophie Rolland, Gustavo Touzet, Nicolas Carrière, Eugénie Mutez, Alexandre Kreisler , et al. · 2023

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a preferred treatment for parkinsonian patients with severe motor fluctuations. Proper targeting of the STN sensorimotor segment appears to be a crucial factor fo…

Indication for molecular testing by multiplex ligation‐dependent probe amplification in parkinsonism Open

Eugénie Mutez, M. Swiderski, David Devos, Caroline Moreau, Guillaume Baille , et al. · 2023

Background and purpose The monogenic forms of Parkinson's disease represent <10% of familial cases and a still lower frequency of sporadic cases. However, guidelines to orient genetic testing are lacking. The aim was to establish the inter…

Can Dopamine Responsiveness Be Predicted in Parkinson’s Disease Without an Acute Administration Test? Open

Nacim Betrouni, Caroline Moreau, Anne‐Sophie Rolland, Nicolas Carrière, Romain Viard , et al. · 2022

Background: Dopamine responsiveness (dopa-sensitivity) is an important parameter in the management of patients with Parkinson’s disease (PD). For quantification of this parameter, patients undergo a challenge test with acute Levodopa admin…

Use of levodopa-carbidopa intestinal gel to treat patients with multiple system atrophy Open

Anne-Sophie Blaise, Elodie Cuvelier, Nicolas Carrière, David Devos, F. Moreau , et al. · 2022

Intrasubject subcortical quantitative referencing to boost MRI sensitivity to Parkinson's disease Open

L. Khedher, J.-M. Bonny, Ana Marquès, E. Durand, Bruno Pereira , et al. · 2022

Preoperative REM Sleep Behavior Disorder and Subthalamic Nucleus Deep Brain Stimulation Outcome in Parkinson Disease 1 Year After Surgery Open

Elsa Besse-Pinot, Bruno Pereira, Franck Durif, Maria Livia Fantini, E. Durand , et al. · 2021

This study provides Class II evidence that in patients with PD eligible for STN-DBS, the presence of probable RBD preoperatively is not associated with poorer outcomes 1 year post surgery.

A French survey on the lockdown consequences of COVID-19 pandemic in Parkinson's disease. The ERCOPARK study Open

Margherita Fabbri, Clémence Leung, Guillaume Baille, Matthieu Béreau, Christine Brefel Courbon , et al. · 2021

High rate of hypomorphic variants as the cause of inherited ataxia and related diseases: study of a cohort of 366 families Open

Mehdi Benkirane, Cécilia Marelli, Claire Guissart, Agathe Roubertie, Elizabeth Ollagnon , et al. · 2021

Small P values may not yield robust findings: an example using REST-meta-PD Open

Xi-Ze Jia, Na Zhao, Hao-Ming Dong, Jiawei Sun, Marek Bartoň , et al. · 2021

Texture-based markers from structural imaging correlate with motor handicap in Parkinson’s disease Open

Nacim Betrouni, Caroline Moreau, Anne‐Sophie Rolland, Nicolas Carrière, Marie Chupin , et al. · 2021

Early cognitive decline after bilateral subthalamic deep brain stimulation in Parkinson's disease patients with GBA mutations Open

Graziella Mangone, Samir Bekadar, Florence Cormier‐Dequaire, Khadija Tahiri, Arlette Welaratne , et al. · 2020

Descriptive analysis of the French NS-Park registry: Towards a nation-wide Parkinson's disease cohort? Open

Louise‐Laure Mariani, Mohamed Doulazmi, Véronique Chaigneau, Christine Brefel‐Courbon, Nicolas Carrière , et al. · 2019

Biallelic MYORG mutation carriers exhibit primary brain calcification with a distinct phenotype Open

Lou Grangeon, David Wallon, Camille Charbonnier, Olivier Quenez, Anne‐Claire Richard , et al. · 2019

Primary familial brain calcification (PFBC) is a rare neurogenetic disorder with diverse neuropsychiatric expression. Mutations in four genes cause autosomal dominant PFBC: SLC20A2, XPR1, PDGFB and PDGFRB. Recently, biallelic mutations in …

Nouvelle stratégie de neuroprotection basée sur la chélation conservatrice du fer dans la maladie de Parkinson Open

Anne‐Sophie Rolland, Caroline Moreau, Jean-Christophe Devedjian, Dominique Deplanque, Régis Bordet , et al. · 2019

Small effect size leads to reproducibility failure in resting-state fMRI studies Open

Xize Jia, Na Zhao, Barek Barton, Roxana G. Burciu, Nicolas Carrière , et al. · 2018

Thousands of papers using resting-state functional magnetic resonance imaging (RS-fMRI) have been published on brain disorders. Results in each paper may have survived correction for multiple comparison. However, since there have been no r…

Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson’s Disease Stages? Open

Lucie Hopes, Guillaume Grolez, Caroline Moreau, Renaud Lopes, Gilles Ryckewaert , et al. · 2016

Each pivotal stage in PD appears to be characterized by putative nigrostriatal MRI biomarkers: iron overload at the de novo stage, striatal shape changes at early-stage disease and generalized striatal atrophy at advanced disease.

Troubles du contrôle des impulsions au cours de la maladie de Parkinson, étude électro-encéphalographique de l’intégration de la récompense et modifications de la connectivité fonctionnelle cérébrale de repos en imagerie par résonance magnétique Open

Nicolas Carrière · 2015

BackgroundIn Parkinson’s disease, dopamine agonists are associated with an increased risk of impulse control disorders (ICD). Their occurrence is supposed to be related with a deregulation of the dopaminergic meso-limbic pathway, involved …

Impulse control disorders in Parkinson’s disease, electro-encephalographic study of reward processing and modifications of resting-state cerebral functional connectivity using magnetic resonance imaging Open

Nicolas Carrière · 2015

ContexteAu cours de la maladie de Parkinson, les agonistes dopaminergiques sont associés à la survenue de troubles du contrôle des impulsions (TCI). Leur physiopathologie est supposée liée à une dérégulation du circuit dopaminergique méso-…

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