Nicolás Dutzan
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View article: Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis
Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis Open
Background This Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impe…
View article: Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier Open
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we report that the clotting factor fibrin is a critical regulator of neutrophil function at the oral mucosal barrier. We demonstrate that commensal microbiota tri…
View article: Increased STAT3 Activation in Periodontitis Drives Inflammatory Bone Loss
Increased STAT3 Activation in Periodontitis Drives Inflammatory Bone Loss Open
Periodontitis is one of the most prevalent human inflammatory diseases. It is characterized by periodontal tissue destruction, progressively driven by the host response. In this regard, cytokines associated with tissue destruction, such as…
View article: Cover Image, Volume 37, Issue 5
Cover Image, Volume 37, Issue 5 Open
The cover image is based on the Original Article A reappraisal of microbiome dysbiosis during experimental periodontitis by Marion Arce et al., https://doi.org/10.1111/omi.12382.
View article: Editorial: Immunology of the Oral Mucosa
Editorial: Immunology of the Oral Mucosa Open
EDITORIAL article Front. Immunol., 25 March 2022Sec. Mucosal Immunity Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.877209
View article: Response to Comments on “Aberrant type 1 immunity drives susceptibility to mucosal fungal infections”
Response to Comments on “Aberrant type 1 immunity drives susceptibility to mucosal fungal infections” Open
Puel and Casanova and Kisand et al . challenge our conclusions that interferonopathy and not IL-17/IL-22 autoantibodies promote candidiasis in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy. We acknowledge that conclusive e…
View article: Single-cell atlas of human oral mucosa reveals a stromal-neutrophil axis regulating tissue immunity in health and inflammatory disease
Single-cell atlas of human oral mucosa reveals a stromal-neutrophil axis regulating tissue immunity in health and inflammatory disease Open
The oral mucosa remains an understudied barrier tissue rich in exposure to antigens, commensals and pathogens. Moreover, it is the tissue where one of the most prevalent human microbe-triggered inflammatory diseases, periodontitis, occurs.…
View article: Fibrin is a critical regulator of neutrophil effector function at mucosal barrier sites
Fibrin is a critical regulator of neutrophil effector function at mucosal barrier sites Open
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we document that the clotting factor fibrin is a critical regulator of neutrophil function at mucosal barriers. We demonstrate that fibrin engages neutrophils thr…
View article: Aberrant type 1 immunity drives susceptibility to mucosal fungal infections
Aberrant type 1 immunity drives susceptibility to mucosal fungal infections Open
Type 1 immunity gives fungi a foothold Type 17 immune responses play a vital role against fungal infections of the mucosa. It remains unclear whether other types of immune responses can also contribute to host defense against these pathoge…
View article: Establishment and Stability of the Murine Oral Microbiome
Establishment and Stability of the Murine Oral Microbiome Open
Commensal microbiomes exert critical functions at barrier sites. In particular, establishment of the commensal microbiome after birth dictates immune functionality and tissue homeostasis at mucosal surfaces. To investigate the establishmen…
View article: Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1
Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1 Open
A patient with leukocyte adhesion deficiency type 1 (LAD1) had severe periodontitis and an intractable, deep, nonhealing sacral wound. We had previously found a dominant interleukin-23-interleukin-17 signature at inflamed sites in humans w…
View article: Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network Open
Immune cell networks in tissues play a vital role in mediating local immunity and maintaining tissue homeostasis, yet little is known of the resident immune cell populations in the oral mucosa and gingiva. We have established a technique f…
View article: Host response mechanisms in periodontal diseases
Host response mechanisms in periodontal diseases Open
Periodontal diseases usually refer to common inflammatory disorders known as gingivitis and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm, including Porphyromonas gingivalis, Aggregatibacter actinomy…
View article: Subgingival Microbial Communities in Leukocyte Adhesion Deficiency and Their Relationship with Local Immunopathology
Subgingival Microbial Communities in Leukocyte Adhesion Deficiency and Their Relationship with Local Immunopathology Open
Leukocyte Adhesion Deficiency I (LAD-I) is a primary immunodeficiency caused by single gene mutations in the CD18 subunit of β2 integrins which result in defective transmigration of neutrophils into the tissues. Affected patients suffer fr…
View article: Changes in lipopolysaccharide profile of Porphyromonas gingivalis clinical isolates correlate with changes in colony morphology and polymyxin B resistance
Changes in lipopolysaccharide profile of Porphyromonas gingivalis clinical isolates correlate with changes in colony morphology and polymyxin B resistance Open
Virulence factors on the surface of Porphyromonas gingivalis constitute the first line of interaction with host cells and contribute to immune modulation and periodontitis progression. In order to characterize surface virulence factors pre…