Nicholas J. Evans
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View article: GlpR Regulates Motility and Viscoelasticity Properties of <i>Pseudomonas aeruginosa</i>
GlpR Regulates Motility and Viscoelasticity Properties of <i>Pseudomonas aeruginosa</i> Open
Despite the onset of highly effective modulator therapies people with Cystic Fibrosis continue to experience recurrent microbial lung infections. Many of these individuals will have at least one positive culture per year for Pseudomonas ae…
View article: Shotgun metagenomic analysis of the oral microbiomes of children with noma reveals a novel disease-associated organism
Shotgun metagenomic analysis of the oral microbiomes of children with noma reveals a novel disease-associated organism Open
Noma is a rapidly progressive orofacial gangrene that predominantly affects children living in extreme poverty. Despite its documentation since antiquity and its designation as a World Health Organisation Neglected Tropical Disease in 2023…
View article: Activation of the <i>Pseudomonas aeruginosa</i> Glycerol Regulon Promotes Antibiotic Persistence and Modulates Virulence Phenotypes
Activation of the <i>Pseudomonas aeruginosa</i> Glycerol Regulon Promotes Antibiotic Persistence and Modulates Virulence Phenotypes Open
Chronic infections with Pseudomonas aeruginosa are a major contributor of lung decline in persons with cystic fibrosis (pwCF). P. aeruginosa establishes life-long infections in the CF airway by utilizing various adaptation strategies to pe…
View article: Population dynamics and morphometrics of Nile monitors along a gradient of urbanization in <scp>KwaZulu</scp>‐Natal, South Africa
Population dynamics and morphometrics of Nile monitors along a gradient of urbanization in <span>KwaZulu</span>‐Natal, South Africa Open
Globally, with the continuous increase in human populations, land use is changing at an unprecedented rate. Little is known about how African reptiles respond to urbanization. We used mark‐resight and baited camera traps to compare populat…
View article: Habitat use and distribution of Nile monitors (Varanus niloticus) in a mosaic of land use types and human population densities in KwaZulu-Natal, South Africa
Habitat use and distribution of Nile monitors (Varanus niloticus) in a mosaic of land use types and human population densities in KwaZulu-Natal, South Africa Open
Context Globally, with the continuous increase in human populations, unprecedented changes in land use are taking place. Little is known about how African reptiles respond to this rapid land use change. Objectives We used sightings to esta…
View article: Multilocus sequence typing of pathogenic treponemes isolated from contagious ovine digital dermatitis stage five lesions: Implications for disease transmission dynamics
Multilocus sequence typing of pathogenic treponemes isolated from contagious ovine digital dermatitis stage five lesions: Implications for disease transmission dynamics Open
Contagious ovine digital dermatitis (CODD) causes a severe, infectious foot disease and lameness of sheep, is common within the UK and is now also emerging in other countries. As well as causing severe animal welfare issues, huge economic …
View article: Molecular Screening for Digital Dermatitis-Associated Treponemes in Bovine Ischaemic Teat Necrosis Lesions and Milk in Dairy Cattle
Molecular Screening for Digital Dermatitis-Associated Treponemes in Bovine Ischaemic Teat Necrosis Lesions and Milk in Dairy Cattle Open
Bovine ischaemic teat necrosis (ITN) is a disease affecting the skin of the teats of dairy cows with an unknown aetiopathogenesis. Digital dermatitis (DD)-associated treponemes have previously been suggested as a potential aetiological age…
View article: Characterisation of Putative Outer Membrane Proteins from Leptospira borgpetersenii Serovar Hardjo-Bovis Identifies Novel Adhesins and Diversity in Adhesion across Genomospecies Orthologs
Characterisation of Putative Outer Membrane Proteins from Leptospira borgpetersenii Serovar Hardjo-Bovis Identifies Novel Adhesins and Diversity in Adhesion across Genomospecies Orthologs Open
Leptospirosis is a zoonotic bacterial disease affecting mammalian species worldwide. Cattle are a major susceptible host; infection with pathogenic Leptospira spp. represents a public health risk and results in reproductive failure and red…
View article: An oral commensal attenuates <i>Pseudomonas aeruginosa</i> -induced airway inflammation and modulates nitrite flux in respiratory epithelium
An oral commensal attenuates <i>Pseudomonas aeruginosa</i> -induced airway inflammation and modulates nitrite flux in respiratory epithelium Open
Polymicrobial airway infections in persons with cystic fibrosis (pwCF) can positively or negatively impact the course of disease. A major CF pathogen, Pseudomonas aeruginosa, often establishes a chronic infection leading to lung deteriorat…
View article: A reduced potential for lameness bacterial transmission by Lucilia sericata larvae and flies through metamorphosis
A reduced potential for lameness bacterial transmission by Lucilia sericata larvae and flies through metamorphosis Open
Lameness in sheep is one of the most serious issues on farms in the UK and worldwide, affecting over 90% of all UK sheep flocks. Despite its severity and prevalence, there are knowledge gaps regarding transmission routes of bacterial patho…
View article: Survival of bovine digital dermatitis treponemes in conditions relevant to the host and farm environment
Survival of bovine digital dermatitis treponemes in conditions relevant to the host and farm environment Open
Treponeme survival conditions identified here should enhance future BDD infection reservoir surveys and enable control measures. Of note, straw or sand containing 5% (w/w) lime should be assessed in BDD field trials. Finally, these data in…
View article: <i>Treponema spp</i>. spirochetes and keratinopathogenic fungi isolated from keratomas in donkeys
<i>Treponema spp</i>. spirochetes and keratinopathogenic fungi isolated from keratomas in donkeys Open
Keratoma is an aberrant keratin mass thought to originate from epidermal horn-producing cells interposed between the stratum medium of the hoof wall and the underlying third phalanx. The cause is unknown, although the presence of keratomas…
View article: Clinical and Pathological Features of Bovine Ischaemic Teat Necrosis
Clinical and Pathological Features of Bovine Ischaemic Teat Necrosis Open
Bovine ischaemic teat necrosis (ITN) is an emerging disease of unknown aetiology affecting mostly dairy cows in the early stages of first lactation and a substantial welfare concern frequently leading to premature culling and economic loss…
View article: An Observational Study Investigating Potential Risk Factors and Economic Impact for Bovine Ischaemic Teat Necrosis on Dairy Farms in Great Britain
An Observational Study Investigating Potential Risk Factors and Economic Impact for Bovine Ischaemic Teat Necrosis on Dairy Farms in Great Britain Open
Bovine ischaemic teat necrosis (ITN) is an emerging disease of unknown aetiology that affects the teats of dairy cattle. It causes economic and animal welfare issues with many animals being culled. No effective treatments or epidemiologica…
View article: The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions
The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions Open
Background: Bovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. The polymicrobial nature of this disease has led to the hypothesis that the foot skin microbiota may b…
View article: Contagious Ovine Digital Dermatitis: A Novel Bacterial Etiology and Lesion Pathogenesis
Contagious Ovine Digital Dermatitis: A Novel Bacterial Etiology and Lesion Pathogenesis Open
Contagious ovine digital dermatitis (CODD) is a severe and common infectious foot disease of sheep and a significant animal welfare issue for the sheep industry in the UK and some European countries. The etiology and pathogenesis of the di…
View article: The Bovine Foot Skin Microbiota is Associated with Host Genotype and the Development of Infectious Digital Dermatitis Lesions
The Bovine Foot Skin Microbiota is Associated with Host Genotype and the Development of Infectious Digital Dermatitis Lesions Open
Bovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. The polymicrobial nature of this disease has led to the hypothesis that the foot skin microbiota may be associated…
View article: Impact of research on contagious ovine digital dermatitis on the knowledge and practices of UK sheep farmers and veterinarians
Impact of research on contagious ovine digital dermatitis on the knowledge and practices of UK sheep farmers and veterinarians Open
Background: Contagious ovine digital dermatitis (CODD) is a common foot disease of sheep which causes a severe form of lameness and can be difficult to control. Recent research has provided evidence‐based guidance on diagnosis, treatment a…
View article: Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms
Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms Open
Here, we report the first complete genomes of three cultivable treponeme species from bovine digital dermatitis (DD) skin lesions, two comparative human treponemes, considered indistinguishable from bovine DD species, and a bovine gastroin…
View article: Measuring the impact of bovine digital dermatitis research on knowledge and practice of biosecurity during cattle foot-trimming
Measuring the impact of bovine digital dermatitis research on knowledge and practice of biosecurity during cattle foot-trimming Open
This research communication reports the results from questionnaires used to identify the impact of recent research into the disinfection of cattle foot-trimming equipment to prevent bovine digital dermatitis (BDD) transmission on (a) biose…
View article: Challenge of Bovine Foot Skin Fibroblasts With Digital Dermatitis Treponemes Identifies Distinct Pathogenic Mechanisms
Challenge of Bovine Foot Skin Fibroblasts With Digital Dermatitis Treponemes Identifies Distinct Pathogenic Mechanisms Open
Bovine digital dermatitis (BDD) is a common infectious disease of digital skin in cattle and an important cause of lameness worldwide, with limited treatment options. It is of increasing global concern for both animal welfare and food secu…
View article: Additional file 6 of The dysbiosis of ovine foot microbiome during the development and treatment of contagious ovine digital dermatitis
Additional file 6 of The dysbiosis of ovine foot microbiome during the development and treatment of contagious ovine digital dermatitis Open
Additional file 6: Supplementary Data 2. Reads per sample data file.
View article: The Dysbiosis of Ovine Foot Microbiome During the Development and Treatment of Contagious Ovine Digital Dermatitis
The Dysbiosis of Ovine Foot Microbiome During the Development and Treatment of Contagious Ovine Digital Dermatitis Open
Background: Contagious Ovine Digital Dermatitis (CODD) is an emerging and common infectious foot disease of sheep which causes severe welfare and economic problems for the sheep industry. The aetiology of the disease is not fully understoo…