Nicolas Blanchard
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View article: Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice
Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice Open
International audience
View article: Id2 levels determine the development of effector vs. exhausted tissue-resident memory CD8+ T cells during CNS chronic infection
Id2 levels determine the development of effector vs. exhausted tissue-resident memory CD8+ T cells during CNS chronic infection Open
Tissue-resident memory T cells (Trms) are essential for regional immunity in non-lymphoid tissues. Although single-cell transcriptomics have revealed Trm heterogeneity in various diseases, the molecular mechanisms behind this diversity are…
View article: Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling
Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling Open
By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS). Intrigu…
View article: Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules
Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules Open
Dendritic cells (DCs) present exogenous antigens via major histocompatibility complex class I (MHC-I) and MHC class II (MHC-II) molecules, activating CD8+ and CD4+ T cells. A critical but poorly understood step in thi…
View article: <scp>SNX17</scp> Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells
<span>SNX17</span> Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells Open
Antigen cross‐presentation is the process whereby small peptides derived from exogenous antigens are attached to MHC‐I molecules triggering CD8+ T lymphocyte activation. The endocytic route of dendritic cells (DCs) is highly specialised fo…
View article: <i>Toxoplasma gondii</i>chronic infection decreases visceral nociception through peripheral opioid receptor signaling
<i>Toxoplasma gondii</i>chronic infection decreases visceral nociception through peripheral opioid receptor signaling Open
By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS). Intrigu…
View article: Author response: Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice
Author response: Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice Open
View article: Id2 levels determine the development of effector vs. exhausted tissue-resident memory CD8<sup>+</sup>T cells during CNS chronic infection
Id2 levels determine the development of effector vs. exhausted tissue-resident memory CD8<sup>+</sup>T cells during CNS chronic infection Open
Tissue-resident memory T cells (Trm) are essential for regional immunity in non-lymphoid tissues. Although single-cell transcriptomics have revealed Trm heterogeneity in various diseases, the molecular mechanisms behind this diversity are …
View article: Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice
Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice Open
CD4 + CD25 + Foxp3 + regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysi…
View article: Author response: Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice
Author response: Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice Open
CD4+CD25+Foxp3+ regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysis of …
View article: Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice
Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice Open
CD4+CD25+Foxp3+ regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysis of …
View article: Protective function and differentiation cues of brain-resident CD8+ T cells during surveillance of latent <i>Toxoplasma gondii</i> infection
Protective function and differentiation cues of brain-resident CD8+ T cells during surveillance of latent <i>Toxoplasma gondii</i> infection Open
Chronic Toxoplasma gondii infection induces brain-resident CD8+ T cells (bTr), but the protective functions and differentiation cues of these cells remain undefined. Here, we used a mouse model of latent infection by T. gondii leading to e…
View article: CD4<sup>+</sup>Trm sustain the chronic phase of auto-immune neuroinflammatory disease
CD4<sup>+</sup>Trm sustain the chronic phase of auto-immune neuroinflammatory disease Open
Therapeutic options against multiple sclerosis (MS) preventing T cell migration to the central nervous system (CNS) have remarkable clinical effects against the relapsing-remitting (RRMS) form of the disease, while they are poorly effectiv…
View article: Protective function and differentiation cues of brain-resident CD8+ T cells during immune surveillance of chronic latent<i>Toxoplasma gondii</i>infection
Protective function and differentiation cues of brain-resident CD8+ T cells during immune surveillance of chronic latent<i>Toxoplasma gondii</i>infection Open
Chronic T. gondii infection induces brain-resident CD8+ T cells (bTr) but their protective functions and differentiation cues remain undefined. Here, we used a mouse model of latent infection by T. gondii leading to effective CD8+ T cell-m…
View article: Chronic IL-1-induced DNA double-strand break response in hippocampal neurons drives cognitive deficits
Chronic IL-1-induced DNA double-strand break response in hippocampal neurons drives cognitive deficits Open
Chronic inflammation characterized by increased cytokine levels, such as interleukin-1 (IL-1), accompanies many neurological diseases but little is known about IL-1 contribution to cognitive impairment and its interplay with epigenetic pro…
View article: Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice
Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice Open
CD4 + CD25 + Foxp3 + regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysi…
View article: IMPACT OF CHRONIC TOXOPLASMA GONDII INFECTION ON THE ONSET AND PROGRESSION OF ALZHEIMER’S DISEASE
IMPACT OF CHRONIC TOXOPLASMA GONDII INFECTION ON THE ONSET AND PROGRESSION OF ALZHEIMER’S DISEASE Open
View article: HOW DOES TOXOPLASMA GONDII MODULATE NEURONAL RESPONSES AND ANTIGEN PRESENTATION TO EVADE IMMUNE RECOGNITION DURING LATENT INFECTION?
HOW DOES TOXOPLASMA GONDII MODULATE NEURONAL RESPONSES AND ANTIGEN PRESENTATION TO EVADE IMMUNE RECOGNITION DURING LATENT INFECTION? Open
View article: Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice
Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice Open
CD4 + CD25 + Foxp3 + regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysi…
View article: The apicoplast is important for the viability and persistence of <i>Toxoplasma gondii</i> bradyzoites
The apicoplast is important for the viability and persistence of <i>Toxoplasma gondii</i> bradyzoites Open
Toxoplasma gondii is responsible for toxoplasmosis, a disease that can be serious when contracted during pregnancy, but can also be a threat for immunocompromised individuals. Acute infection is associated with the tachyzoite form that spr…
View article: Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown Open
Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8 + T cells are found in MS lesions, and antigen (Ag) presentation at …
View article: Datasets used for the publication: UAV-Lidar reveals that canopy structure mediates the influence of edge effects on forest diversity, function and microclimate
Datasets used for the publication: UAV-Lidar reveals that canopy structure mediates the influence of edge effects on forest diversity, function and microclimate Open
Datasets used for the publication: UAV-Lidar reveals that canopy structure mediates the influence of edge effects on forest diversity, function and microclimate. The file "Blanchard_et_al_JoE_2023_data_plot_trees.csv" contains individual t…
View article: Datasets used for the publication: UAV-Lidar reveals that canopy structure mediates the influence of edge effects on forest diversity, function and microclimate
Datasets used for the publication: UAV-Lidar reveals that canopy structure mediates the influence of edge effects on forest diversity, function and microclimate Open
Datasets used for the publication: UAV-Lidar reveals that canopy structure mediates the influence of edge effects on forest diversity, function and microclimate. The file "Blanchard_et_al_JoE_2023_data_plot_trees.csv" contains individual t…
View article: The apicoplast is important for the viability and persistence of<i>Toxoplasma gondii</i>bradyzoites
The apicoplast is important for the viability and persistence of<i>Toxoplasma gondii</i>bradyzoites Open
Toxoplasma gondii is responsible for toxoplasmosis, a disease that can be serious when contracted during pregnancy, but can also be a threat for immunocompromised individuals. Acute infection is associated with the tachyzoite form that spr…
View article: Efficient Cholesterol Transport in Dendritic Cells Defines Optimal Exogenous Antigen Presentation and Toxoplasma gondii Proliferation
Efficient Cholesterol Transport in Dendritic Cells Defines Optimal Exogenous Antigen Presentation and Toxoplasma gondii Proliferation Open
Dendritic cells are the most powerful antigen-presenting cells of the immune system. They present exogenous antigens associated with Major Histocompatibility Complex (MHC) Class II molecules through the classical pathway to stimulate CD4+ …
View article: Microbial (co)infections: Powerful immune influencers
Microbial (co)infections: Powerful immune influencers Open
It is well established that by modulating various immune functions, host infection may alter the course of concomitant inflammatory diseases, of both infectious and autoimmune etiologies. Beyond the major impact of commensal microbiota on …
View article: Sport de haut niveau et maternité, c'est possible !
Sport de haut niveau et maternité, c'est possible ! Open
International audience
View article: New Insights into Blood Circulating Lymphocytes in Human Pneumocystis Pneumonia
New Insights into Blood Circulating Lymphocytes in Human Pneumocystis Pneumonia Open
The host lymphocyte response is decisive in Pneumocystis pneumonia (PCP) pathophysiology but little is known of the specific roles of lymphocyte subpopulations in this fungal infection. Peripheral NK, NKT, B, TCD4+ and TCD8+ subpopulations…
View article: Towards a Large-Scale Assessment of the Relationship Between Biological and Chronological Aging: The Inspire Mouse Cohort
Towards a Large-Scale Assessment of the Relationship Between Biological and Chronological Aging: The Inspire Mouse Cohort Open
View article: The UPR sensor IRE1α promotes dendritic cell responses to control <i>Toxoplasma gondii</i> infection
The UPR sensor IRE1α promotes dendritic cell responses to control <i>Toxoplasma gondii</i> infection Open