Nicolas Jouand
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View article: Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment
Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment Open
Attenuated measles virus (MV) exerts its oncolytic activity in malignant pleural mesothelioma (MPM) cells that lack type-I interferon (IFN-I) production or responsiveness. However, other cells in the tumor microenvironment (TME), such as m…
View article: Supplementary Table 2 from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
Supplementary Table 2 from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma Open
Supplementary Table 2
View article: Supplementary Figures 1-7 and Supplementary Tables 1 and 3 from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
Supplementary Figures 1-7 and Supplementary Tables 1 and 3 from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma Open
Supplementary Figures 1-7 and Supplementary Tables 1 and 3
View article: Data from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
Data from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma Open
MicroRNAs (miRNA), small noncoding RNAs that regulate gene expression, exist not only in cells but also in a variety of body fluids. These circulating miRNAs could enable intercellular communication. miRNAs are packaged in membrane-encapsu…
View article: Supplementary Table 2 from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
Supplementary Table 2 from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma Open
Supplementary Table 2
View article: Supplementary Figures 1-7 and Supplementary Tables 1 and 3 from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
Supplementary Figures 1-7 and Supplementary Tables 1 and 3 from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma Open
Supplementary Figures 1-7 and Supplementary Tables 1 and 3
View article: Data from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
Data from MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma Open
MicroRNAs (miRNA), small noncoding RNAs that regulate gene expression, exist not only in cells but also in a variety of body fluids. These circulating miRNAs could enable intercellular communication. miRNAs are packaged in membrane-encapsu…
View article: Human gut microbiota-reactive DP8α regulatory T cells, signature and related emerging functions
Human gut microbiota-reactive DP8α regulatory T cells, signature and related emerging functions Open
In mice, microbiota-induced Tregs both maintain intestinal homeostasis and provide resistance to immuno-pathologies in the adult. Identifying their human functional counterpart therefore represents an important goal. We discovered, in the …
View article: Defining the Immune Checkpoint Landscape in Human Colorectal Cancer Highlights the Relevance of the TIGIT/CD155 Axis for Optimizing Immunotherapy
Defining the Immune Checkpoint Landscape in Human Colorectal Cancer Highlights the Relevance of the TIGIT/CD155 Axis for Optimizing Immunotherapy Open
While immune checkpoint (IC) therapies, particularly those targeting the PD-1/PD-L1 axis, have revolutionized the treatment of melanoma and several other cancers, their effect remains very limited in colorectal cancer (CRC). To define a co…
View article: A novel and efficient approach to high-throughput production of HLA-E/peptide monomer for T-cell epitope screening
A novel and efficient approach to high-throughput production of HLA-E/peptide monomer for T-cell epitope screening Open
View article: High-Density of FcγRIIIA+ (CD16+) Tumor-Associated Neutrophils in Metastases Improves the Therapeutic Response of Cetuximab in Metastatic Colorectal Cancer Patients, Independently of the HLA-E/CD94-NKG2A Axis
High-Density of FcγRIIIA+ (CD16+) Tumor-Associated Neutrophils in Metastases Improves the Therapeutic Response of Cetuximab in Metastatic Colorectal Cancer Patients, Independently of the HLA-E/CD94-NKG2A Axis Open
Antibody-dependent cellular cytotoxicity (ADCC) in the anti-tumor effect of cetuximab in metastatic colorectal cancer (mCRC) is only based on the impact of FcγRIIIA (CD16) polymorphisms as predictive of therapeutic response. However, natur…
View article: Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients
Phase I/II clinical trial of adoptive cell transfer of sorted specific T cells for metastatic melanoma patients Open
Adoptive cell transfer (ACT) of tumor-specific T lymphocytes represents a relevant therapeutic strategy to treat metastatic melanoma patients. Ideal T-cells should combine tumor specificity and reactivity with survival in vivo, while avoid…
View article: Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19
Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19 Open
Human serum contains large amounts of anti-carbohydrate antibodies, some of which may recognize epitopes on viral glycans. Here, we tested the hypothesis that such antibodies may confer protection against COVID-19 so that patients would be…
View article: PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy
PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy Open
Background Clinical benefit from programmed cell death 1 receptor (PD-1) inhibitors relies on reinvigoration of endogenous antitumor immunity. Nonetheless, robust immunological markers, based on circulating immune cell subsets associated w…
View article: MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma Open
MicroRNAs (miRNA), small noncoding RNAs that regulate gene expression, exist not only in cells but also in a variety of body fluids. These circulating miRNAs could enable intercellular communication. miRNAs are packaged in membrane-encapsu…
View article: The inhibitory receptor CD94/NKG2A on CD8+ tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression
The inhibitory receptor CD94/NKG2A on CD8+ tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression Open
View article: HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition
HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition Open
Immune response against human cytomegalovirus (HCMV) includes a set of persistent cytotoxic NK and CD8 T cells devoted to eliminate infected cells and to prevent reactivation. CD8 T cells against HCMV antigens (pp65, IE1) presented by HLA …
View article: CD40L confers helper functions to human intra-melanoma class-I-restricted CD4<sup>+</sup>CD8<sup>+</sup>double positive T cells
CD40L confers helper functions to human intra-melanoma class-I-restricted CD4<sup>+</sup>CD8<sup>+</sup>double positive T cells Open
Although CD4+CD8+ double positive (DP) T cells represent a small fraction of peripheral T lymphocytes in healthy human donors, their frequency is often increased under pathological conditions (in blood and targeted ti…