Nicolas Levoin
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View article: Research towards selective inhibition of the CLK3 kinase
Research towards selective inhibition of the CLK3 kinase Open
The cdc2-like kinases (CLKs), are a family of kinases that attracted recently the interest of scientists due to their significant biological roles, in particular in the regulation of the mRNA splicing process. Among the four isoforms of CL…
View article: Research towards selective inhibition of the CLK3 kinase
Research towards selective inhibition of the CLK3 kinase Open
The cdc2-like kinases (CLKs), are a family of kinases that attracted recently the interest of scientists due to their significant biological roles, in particular in the regulation of mRNA splicing process. Among the four isoforms of CLKs, …
View article: Synthesis and biological studies on ovarian cancer cells of new heterocyclic molecules inspired by MIM1, an inhibitor of the anti-apoptotic protein Mcl-1
Synthesis and biological studies on ovarian cancer cells of new heterocyclic molecules inspired by MIM1, an inhibitor of the anti-apoptotic protein Mcl-1 Open
Research on new and potent inhibitors of anti-apoptotic proteins is a very active and promising topic in bioorganic and medicinal chemistry.
View article: CD95L concatemers highlight different stoichiometries of CD95‐mediated apoptotic and nonapoptotic pathways
CD95L concatemers highlight different stoichiometries of CD95‐mediated apoptotic and nonapoptotic pathways Open
To better understand the stoichiometry of CD95L required to trigger apoptotic and nonapoptotic signals, we generated several CD95L concatemers from dimer to hexamer conjugated via a flexible link (GGGGS) 2 . These ligands reveal that altho…
View article: CD95L concatemers highlight difference in the manner CD95-mediated apoptotic and non-apoptotic pathways are triggered
CD95L concatemers highlight difference in the manner CD95-mediated apoptotic and non-apoptotic pathways are triggered Open
To better understand the stoichiometry of CD95L required to trigger apoptotic and non-apoptotic signals, we generated several CD95L concatemers from dimer to hexamer conjugated via a flexible link (GGGGS) 2 . These ligands reveal that alth…
View article: Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases
Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases Open
Three series of our lead CLK1 inhibitor DB18 have been designed, synthetized and tested against CLKs and DYRK1A kinases. Their cytotoxicity was subsequently measured on seven representative cancer cell lines. Guided by docking experiments,…
View article: Synthesis and biological evaluation of FJ-809, a compound originally described as MIM1 and an inhibitor of the anti-apoptotic protein Mcl-1
Synthesis and biological evaluation of FJ-809, a compound originally described as MIM1 and an inhibitor of the anti-apoptotic protein Mcl-1 Open
The development of inhibitors of anti-apoptotic proteins, such as Mcl-1, is currently a very active area in the field of cancer research.
View article: CCDC 2006655: Experimental Crystal Structure Determination
CCDC 2006655: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2006657: Experimental Crystal Structure Determination
CCDC 2006657: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2006656: Experimental Crystal Structure Determination
CCDC 2006656: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2007740: Experimental Crystal Structure Determination
CCDC 2007740: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CD95 Structure, Aggregation and Cell Signaling
CD95 Structure, Aggregation and Cell Signaling Open
CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its ligand CD95L brings to a next level its aggregation and triggers different signaling pathways, leading to cell motility, differentiation or cell death. T…