Explanipedia

Variation in central venous catheter practice in paediatric acute care cardiology Open

Megan Rodts, Colleen Pater, Sonali S. Patel, Amy Schiller, Margaret Graupe , et al. · 2025

Introduction: Central venous catheter use is not standardised in paediatric cardiology, yet it is associated with additional morbidity. We aimed to characterise variation in central venous catheter use and complications across paediatric a…

Cardiac Juvenile Xanthogranulomatosis in an Infant Presenting With Pericardial Effusion Open

Mohammad Qasim Mehdi, Pezad Doctor, Shannon Kelley, Nicolas Madsen · 2025

Understanding the origin of pericardial effusion provides insights on management, risk of recurrence, and outcome. In infants, pericardial effusion can have various causes, including multisystem disease, infection, or cardiac tumors. We de…

Angiographic tool to detect pulmonary arteriovenous malformations in single ventricle physiology Open

Stephen B. Spurgin, Yousef Arar, Thomas M. Zellers, Jijia Wang, Nicolas Madsen , et al. · 2024

Objective: Individuals with single ventricle physiology who are palliated with superior cavopulmonary anastomosis (Glenn surgery) may develop pulmonary arteriovenous malformations. The traditional tools for pulmonary arteriovenous malforma…

Angiographic Tool to Detect Pulmonary Arteriovenous Malformations in Single Ventricle Physiology Open

Stephen B. Spurgin, Yousef Arar, Thomas M. Zellers, Jijia Wang, Nicolas Madsen , et al. · 2024

Background Individuals with single ventricle physiology who are palliated with superior cavopulmonary anastomosis (Glenn surgery) may develop pulmonary arteriovenous malformations (PAVMs). The traditional tools for PAVM diagnosis are often…

Mental Health Conditions Among Children and Adolescents With Congenital Heart Disease: A Danish Population-Based Cohort Study Open

Kimberley G. Miles, Dóra Körmendiné Farkas, Kristina Laugesen, Henrik Toft Sørensen, Nadine A. Kasparian , et al. · 2023

BACKGROUND: Despite the known mental health burden among children with congenital heart disease (CHD), the literature is constrained by a lack of comparison cohorts and population-based follow-up data. We examined the incidence of mental h…

Accelerating improvement: The Pediatric Acute Care Cardiology Collaborative data timeliness project Open

Margaret Graupe, Ashlin Tignor, Kelly Veneziale, Megan E. Jensen, Lara Khadr , et al. · 2022

Background The Pediatric Acute Care Cardiology Collaborative (PAC3) is a learning network focused on improving acute care cardiology patient outcomes. Data submission timeliness is a vulnerability for PAC3 and most clinical registries, dir…

Family-centered care and acute care cardiology: borrowing lessons from other disciplines Open

Dana B. Gal, Danton Char, Jeffery B. Anderson, David S. Cooper, Nicolas Madsen · 2022

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Advanced fellowship training for cardiology fellows in acute care cardiology Open

Colleen Pater, Ivan Wilmot, Jennifer Russell, Nicolas Madsen · 2022

Hospitalised children have become more medically complex and increasingly require specialised teams and units properly equipped to care for them. Within paediatric cardiology, this trend, which is well demonstrated by the expansion of card…

Positive predictive value of congenital heart disease diagnostic codes in the Danish National Patient Registry Open

Sara Schwartz, Mette Glavind Bülow Pedersen, Trine Frøslev, Nicolas Madsen, Morten Smærup Olsen · 2022

Paediatric acute care cardiology collaborative data registry validation Open

Lara Khadr, Stephen A. Hart, Susan Schachtner, Margaret Graupe, Kelly Veneziale , et al. · 2022

Background: The Pediatric Acute Care Cardiology Collaborative (PAC 3 ) was established to improve acute care cardiology outcomes through the development of an accurate and well-validated clinical registry. We report the validation results …

The low incidence of clinically significant heart disease in school-age children following and protect health COVID-19 Open

Adam W. Powell, Christopher Statile, Nicolas Madsen, Allison Divanović, Sean M. Lang · 2022

The burden of clinically-apparent cardiac injury secondary to coronavirus disease 2019 (COVID-19) in school-age children is unclear. Over 12 months at a large academic pediatric hospital in the Midwestern portion of the United States, ther…

Increased Arterial Stiffness Is Associated With Reduced Diastolic Function in Youth With Obesity and Type 2 Diabetes Open

Nicolas Madsen, Jessica Haley, Ryan A. Moore, Philip R. Khoury, Elaine M. Urbina · 2021

Background: Increased arterial stiffness is associated with diastolic dysfunction in adults. Data in youth are lacking, so we examined the impact of arterial stiffness on diastolic function in youth. Methods: We obtained diastolic function…

Association of Maternal Hypothyroidism With Cardiovascular Diseases in the Offspring Open

Maohua Miao, Hui Liu, Yuan Wei, Nicolas Madsen, Yongfu Yu , et al. · 2021

Background No previous study has examined the effect of maternal hypothyroidism on a broad spectrum of cardiovascular disease (CVD) endpoints in the offspring. Methods A nationwide population-based cohort study based on the linkage of seve…

Return to work following adverse cardiovascular events in adults with congenital heart disease Open

Patrick D. Evers, Dóra Körmendiné Farkas, Cathrine F. Hjorth, Michael Khoury, Morten Olsen , et al. · 2021

Proton-pump inhibitor use and risk of community-acquired pneumonia in congenital heart disease patients Open

Patrick D. Evers, Dóra Körmendiné Farkas, Michael Khoury, Morten Olsen, Nicolas Madsen · 2021

High Acuity Therapy Variation Across Pediatric Acute Care Cardiology Units: Results from the Pediatric Acute Care Cardiology Collaborative Hospital Surveys Open

Ashraf S. Harahsheh, Alaina K. Kipps, Stephen A. Hart, Steven C. Cassidy, Martha L. Clabby , et al. · 2021

Effectiveness and Safety of Statin Therapy in Children: A Real-World Clinical Practice Experience Open

Rae-Ellen W. Kavey, Cedric Manlhiot, Kyle Runeckles, Tanveer Collins, Samuel S. Gidding , et al. · 2020

Intensive Care Unit and Acute Care Unit Length of Stay After Congenital Heart Surgery Open

Stephen A. Hart, Ronn E. Tanel, Alaina K. Kipps, Amanda Hoerst, Margaret Graupe , et al. · 2020

Time series evaluation of improvement interventions to reduce alarm notifications in a paediatric hospital Open

Colleen Pater, Tina Sosa, Jacquelyn Boyer, Rhonda Cable, Melinda J Egan , et al. · 2020

Background10 The Joint Commission identified inpatient alarm reduction as an opportunity to improve patient safety; enhance patient, family and nursing satisfaction; and optimise workflow. We used quality improvement (QI) methods to safely…

Center Variation in Chest Tube Duration and Length of Stay After Congenital Heart Surgery Open

Katherine E. Bates, Nicolas Madsen, Lara Khadr, Zhiqian Gao, Kari Crawford , et al. · 2019

Ischemic Stroke in Adults With Congenital Heart Disease: A Population‐Based Cohort Study Open

Mette Glavind Bülow Pedersen, Morten Smærup Olsen, Morten Schmidt, Søren Paaske Johnsen, Christopher P. Learn , et al. · 2019

Background Congenital heart disease ( CHD ) is associated with risk factors for ischemic stroke including cardiac arrhythmias and heart failure. However, few long‐term follow‐up data exist on ischemic stroke risk and associated mortality i…

Variation in care practices across pediatric acute care cardiology units: Results of the Pediatric Acute Care Cardiology Collaborative (PAC <sup>3</sup> ) hospital survey Open

Amanda Hoerst, Adnan Bakar, Steven C. Cassidy, Martha L. Clabby, Erica Del Grippo , et al. · 2019

The PAC³ hospital survey is the most comprehensive description of systems and care practices unique to CACUs to date. There exists considerable heterogeneity among unit composition and variation in care practices. These variatio…

Longitudinal Health Care Cost in Hypoplastic Left Heart Syndrome Palliation Open

Jesse E. Hansen, Nicolas Madsen, Laurie Bishop, David L.S. Morales, Jeffrey Anderson · 2018

Risk of Dementia in Adults With Congenital Heart Disease Open

Carina N. Bagge, Victor W. Henderson, Henning Laursen, Kasper Adelborg, Morten Olsen , et al. · 2018

Background: More children with congenital heart disease (CHD) are surviving to adulthood, and CHD is associated with risk factors for dementia. We compared the risk of dementia in CHD adults to that of the general population. Methods: In t…

Arterial Thickness and Stiffness Are Independently Associated with Left Ventricular Strain Open

Smita Mehta, Philip R. Khoury, Nicolas Madsen, Lawrence M. Dolan, Thomas R. Kimball , et al. · 2017

Congenital heart disease and the prevalence of underweight and obesity from age 1 to 15 years: data on a nationwide sample of children Open

Sara Schwartz, Morten Olsen, Jessica G. Woo, Nicolas Madsen · 2017

The CHD population had an increased prevalence of underweight compared with the general population. Data indicated potential for BMI normalisation among those initially underweight at age 1 year. The prevalence of obesity in children with …

Utilizing a transfer of care bundle to reduce unplanned readmissions to the cardiac intensive care unit Open

Jean Storey, Jonathan W. Byrnes, Jeffrey Anderson, James Brown, Katherine Clarke‐Myers , et al. · 2017

Hospital-based intensive care is known to be a significant driver of healthcare costs. In the USA, intensive care unit (ICU) care accounted for 13% of all hospital costs in 2005.1 One aspect of ICU care that has been found to be both a dri…

Cardiac surgery in patients with congenital heart disease is associated with acute kidney injury and the risk of chronic kidney disease Open

Nicolas Madsen, Stuart L. Goldstein, Trine Frøslev, Christian Fynbo Christiansen, Morten Olsen · 2017

Congenital Heart Disease With and Without Cyanotic Potential and the Long‐term Risk of Diabetes Mellitus: A Population‐Based Follow‐up Study Open

Nicolas Madsen, Bradley S. Marino, Jessica G. Woo, Reimar W. Thomsen, Jørgen Videbœk , et al. · 2016

Background Long‐term survival for persons born with congenital heart disease ( CHD ) is improved, but limited knowledge exists of this growing population's acquired cardiovascular risk profile. This study's purpose was to assess CHD surviv…

A 14-Year-Old Boy with Unusual Presentation of Respiratory Distress Open

Adam W. Powell, Samuel P. Hanke, James S. Tweddell, Nicolas Madsen · 2016

There are multiple cardiac etiologies for wheezing and respiratory distress which require a high degree of suspicion for the pediatrician to diagnose. We present a case of a patient with a history of long-standing mild persistent asthma wi…

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