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View article: Prevalence and Risk Factors Associated with Professional Burnout in Spanish Intensive Care Units
Prevalence and Risk Factors Associated with Professional Burnout in Spanish Intensive Care Units Open
View article: Thank you, Professor Gattinoni†, and have a good trip to eternity!
Thank you, Professor Gattinoni†, and have a good trip to eternity! Open
View article: A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study
A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study Open
View article: Serum-derived host miR-423-5p and miR-378a-3p as molecular markers for severe tuberculosis: a promising prognostic tool for survival
Serum-derived host miR-423-5p and miR-378a-3p as molecular markers for severe tuberculosis: a promising prognostic tool for survival Open
Tuberculosis (TB) remains a leading cause of infectious disease-related mortality. Annually, 10 million people contract TB, resulting in 1.5 million deaths, despite being a preventable and curable disease. Severe TB cases necessitate Inten…
View article: Blood matters: the hematological signatures of Coronavirus infection
Blood matters: the hematological signatures of Coronavirus infection Open
Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well …
View article: A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study.
A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study. Open
Background The trend overtime and across different geographical areas of outcomes and management with noninvasive ventilation or invasive mechanical ventilation in patients admitted for acute exacerbations of chronic obstructive pulmonary …
View article: WCN24-360 The use of convalescent plasma in a kidney transplant recipient COVID-19 patient: A case report from the perspective of viral load evolution and immune response
WCN24-360 The use of convalescent plasma in a kidney transplant recipient COVID-19 patient: A case report from the perspective of viral load evolution and immune response Open
By mid-2020, most of the world was grappling with the millions of deaths caused by the COVID-19 pandemic. In this context, Uruguay was an outlier, managing the situation with remarkable success 1. By this time, convalescent plasma (CP) the…
View article: Adherence to low tidal volume in the transition to spontaneous ventilation in patients with acute respiratory failure in intensive care units in Latin America (SPIRAL): a study protocol
Adherence to low tidal volume in the transition to spontaneous ventilation in patients with acute respiratory failure in intensive care units in Latin America (SPIRAL): a study protocol Open
Objective: Patients with acute respiratory failure often require mechanical ventilation to reduce the work of breathing and improve gas exchange; however, this may exacerbate lung injury. Protective ventilation strategies, characterized by…
View article: Aderência ao volume corrente baixo na transição para ventilação espontânea em pacientes com insuficiência respiratória aguda em unidades de terapia intensiva na América Latina (SPIRAL): um protocolo de estudo
Aderência ao volume corrente baixo na transição para ventilação espontânea em pacientes com insuficiência respiratória aguda em unidades de terapia intensiva na América Latina (SPIRAL): um protocolo de estudo Open
RESUMO Objetivo: Pacientes com insuficiência respiratória aguda frequentemente necessitam de ventilação mecânica para reduzir o trabalho respiratório e melhorar a troca gasosa; no entanto, a ventilação mecânica pode exacerbar a lesão pulmo…
View article: Características de pacientes con SARS-CoV-2 en estado crítico en un centro COVID-19 de referencia en Uruguay
Características de pacientes con SARS-CoV-2 en estado crítico en un centro COVID-19 de referencia en Uruguay Open
Introducción: la pandemia de COVID-19 produjo una alta mortalidad en el mundo. Sin embargo, las presentaciones más críticas de la enfermedad han sido poco caracterizadas en nuestra región.Objetivo: estudiar la presentación clínica, evoluci…
View article: A comparative NMR-based metabolomics study of lung parenchyma of severe COVID-19 patients
A comparative NMR-based metabolomics study of lung parenchyma of severe COVID-19 patients Open
COVID-19 was the most significant infectious-agent-related cause of death in the 2020-2021 period. On average, over 60% of those admitted to ICU facilities with this disease died across the globe. In severe cases, COVID-19 leads to respira…
View article: What have we learned from a case of convalescent plasma treatment in a two-time kidney transplant recipient COVID-19 patient? A case report from the perspective of viral load evolution and immune response
What have we learned from a case of convalescent plasma treatment in a two-time kidney transplant recipient COVID-19 patient? A case report from the perspective of viral load evolution and immune response Open
Coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, can have a wide range of clinical manifestations, ranging from asymptomatic disease to potentially…
View article: Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study
Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study Open
View article: Coronavirus pathogenesis in mice explains the SARS-CoV-2 multi-organ spread by red blood cells hitch-hiking
Coronavirus pathogenesis in mice explains the SARS-CoV-2 multi-organ spread by red blood cells hitch-hiking Open
SARS-CoV-2 infection causes a multisystemic disease that affects numerous organs beyond the respiratory system. Thus, it is well known that COVID-19 is associated with a wide range of hematological disorders; however, it remains unclear ho…
View article: One-year monitoring SARS-CoV-2 RNA surface contamination in hospitals reveals no correlation with organic material and negative pressure as a limiting factor for contamination
One-year monitoring SARS-CoV-2 RNA surface contamination in hospitals reveals no correlation with organic material and negative pressure as a limiting factor for contamination Open
View article: Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study Open
View article: Early lung autopsy in deceased patients with acute respiratory distress syndrome due to infection by SARS-CoV-2
Early lung autopsy in deceased patients with acute respiratory distress syndrome due to infection by SARS-CoV-2 Open
View article: ¿What did we learn from Convalescent plasma treatment in a COVID-19 patient two-time kidney transplanted? A case report from the viral and immune response evolution perspective
¿What did we learn from Convalescent plasma treatment in a COVID-19 patient two-time kidney transplanted? A case report from the viral and immune response evolution perspective Open
Background: COVID-19, an infectious disease caused by SARS-CoV-2 virus, can provoke a vast range of clinical manifestations, ranging from asymptomatic to potentially life-threatening complications. At the beginning, convalescent plasma the…
View article: Autopsia pulmonar precoz en pacientes fallecidos con síndrome de distrés respiratorio agudo secundario a infección por SARS-CoV-2
Autopsia pulmonar precoz en pacientes fallecidos con síndrome de distrés respiratorio agudo secundario a infección por SARS-CoV-2 Open
This was an observational prospective study of patients who had died at the intensive care unit (ICU) (teaching hospital; reference center for patients with SARS-CoV-2 infection) with a confirmed diagnosis of SARS-CoV-2 infection. The stud…
View article: A comparative NMR-based metabolomics study of lung parenchyma of severe COVID‑19 patients
A comparative NMR-based metabolomics study of lung parenchyma of severe COVID‑19 patients Open
The COVID-19 pandemic was the leading cause of mortality due to a single infectious agent in 2020 and 2021. The fatality rate for individuals admitted to the ICU for this condition was over 60%. A metabolomic analysis based on nuclear magn…
View article: Clinical characteristics, systemic complications, and in-hospital outcomes for patients with COVID-19 in Latin America. LIVEN-Covid-19 study: A prospective, multicenter, multinational, cohort study
Clinical characteristics, systemic complications, and in-hospital outcomes for patients with COVID-19 in Latin America. LIVEN-Covid-19 study: A prospective, multicenter, multinational, cohort study Open
Purpose The COVID-19 pandemic has spread worldwide, and almost 396 million people have been infected around the globe. Latin American countries have been deeply affected, and there is a lack of data in this regard. This study aims to ident…
View article: One-Year Monitoring SARS-CoV-2 RNA Surface Contamination in Hospitals Reveals No Correlation with Organic Material and Negative Pressure as a Limiting Factor for Contamination
One-Year Monitoring SARS-CoV-2 RNA Surface Contamination in Hospitals Reveals No Correlation with Organic Material and Negative Pressure as a Limiting Factor for Contamination Open
View article: Serum MicroRNAs as Biomarkers of Sepsis and Resuscitation
Serum MicroRNAs as Biomarkers of Sepsis and Resuscitation Open
There is a lack of biomarkers of sepsis and the resuscitation status. Our objective was to prove that the serum expression of certain microribonucleic acids (miRNAs) is differentially regulated in sepsis and is sensitive to different resus…
View article: Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS
Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS Open
Background Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 (COVID-19) is associated with ARDS in the more severe cases. This study…
View article: Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay
Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay Open
Uruguay controlled the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein, we analyzed the country-wide genetic…
View article: Driving Pressure Is a Risk Factor for ARDS in Mechanically Ventilated Subjects Without ARDS
Driving Pressure Is a Risk Factor for ARDS in Mechanically Ventilated Subjects Without ARDS Open
In the subjects without ARDS, a higher level of ΔP on the first day of mechanical ventilation was associated with later development of ARDS. (ClinicalTrials.gov registration NCT02731898.).
View article: Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H Spike mutations in Uruguay
Emergence and spread of a B.1.1.28-derived P.6 lineage with Q675H and Q677H Spike mutations in Uruguay Open
Uruguay was able to control the viral dissemination during the first nine months of the SARS-CoV-2 pandemic. Unfortunately, towards the end of 2020, the number of daily new cases exponentially increased. Herein we analyzed the country-wide…
View article: Clinical and epidemiological features of tuberculosis isolated from critically ill patients
Clinical and epidemiological features of tuberculosis isolated from critically ill patients Open
Human tuberculosis is still a major world health concern. In Uruguay, contrary to the world trend, an increase in cases has been observed since 2006. Although the incidence of MDR-resistant strains is low and no cases of XDR-TB were regist…
View article: Machine learning predicts mortality based on analysis of ventilation parameters of critically ill patients: multi-centre validation
Machine learning predicts mortality based on analysis of ventilation parameters of critically ill patients: multi-centre validation Open
View article: Propensity-Adjusted Comparison of Mortality of Elderly Versus Very Elderly Ventilated Patients
Propensity-Adjusted Comparison of Mortality of Elderly Versus Very Elderly Ventilated Patients Open
Age was an independent and unchangeable risk factor for death in mechanically ventilated subjects. However, survival rates of very elderly subjects were > 50%. Denial of critical care based solely on age is not justified. (ClinicalTrials.g…