Nicolas Pallet
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View article: The lipidome of the kidney tubules of ob/ob mice is affected at the infralesional level
The lipidome of the kidney tubules of ob/ob mice is affected at the infralesional level Open
View article: Time course profiling of the kynurenine pathway activity in a pig model of crescentic glomerulonephritis
Time course profiling of the kynurenine pathway activity in a pig model of crescentic glomerulonephritis Open
View article: Interferon gamma induced-ACSL5 shapes the lipidome of kidney tubular cells
Interferon gamma induced-ACSL5 shapes the lipidome of kidney tubular cells Open
Acyl-CoA synthetase long-chain family (ACSL) enzymes are critical in the activation of long-chain fatty acid. To determine the regulatory mechanisms of ACSL5 and its biological functions within the kidney tubule, we generated transcriptomi…
View article: Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection
Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection Open
Graft endothelial cells (ECs) express donor alloantigens and encounter cytotoxic T lymphocytes (CTLs) but are generally spared during T cell-mediated rejection (TCMR), which predominantly affects epithelial structures. The mechanisms under…
View article: Long‐term complications in acute porphyria
Long‐term complications in acute porphyria Open
New treatment options and low attack‐related mortality have changed the life expectancy of patients with acute porphyria (AP) to that of the general population. Clinicians should therefore be aware of the long‐term complications of AP, whi…
View article: STAT3 drives the expression of ACSL4 in acute kidney injury
STAT3 drives the expression of ACSL4 in acute kidney injury Open
View article: Diagnostic Yield of APOL1 p.N264K Variant Screening in Daily Practice
Diagnostic Yield of APOL1 p.N264K Variant Screening in Daily Practice Open
Observational and case-control studies in large American cohorts of individuals of African ancestry with available genetic information have demonstrated a strong protective effect of the p.N264K variant of APOL1 on the risk of chronic kidn…
View article: O24 <i>APOL1</i> genotype is a major determinant of lupus nephritis severity in patients of African ancestry
O24 <i>APOL1</i> genotype is a major determinant of lupus nephritis severity in patients of African ancestry Open
Objective G1 and G2 polymorphisms of APOL1 gene, exclusively found among patients of African ancestry, have been associated with chronic kidney disease (CKD) and collapsing glomerulopathy. We investigated their impact on lupus nephr…
View article: Lipidomic Profiling of Kidney Cortical Tubule Segments Identifies Lipotypes with Physiological Implications
Lipidomic Profiling of Kidney Cortical Tubule Segments Identifies Lipotypes with Physiological Implications Open
A detailed knowledge of the lipid composition of components of nephrons is crucial for understanding physiological processes and the development of kidney diseases. However, the lipidomic composition of kidney tubular segments is unknown. …
View article: #5790 IMPAIRED FATTY ACID METABOLISM PERPETUATES LIPOTOXICITY ALONG THE TRANSITION TO CHRONIC KIDNEY INJURY
#5790 IMPAIRED FATTY ACID METABOLISM PERPETUATES LIPOTOXICITY ALONG THE TRANSITION TO CHRONIC KIDNEY INJURY Open
Background and Aims Understanding the cell-intrinsic mechanisms contributing to the maintenance of a dysfunctional cellular state in chronic kidney disease (CKD) and identifying therapeutic targets are research priorities in renal medicine…
View article: #3155 APOL1 GENOTYPE IS A MAJOR DETERMINANT OF LUPUS NEPHRITIS SEVERITY IN PATIENTS OF AFRICAN ANCESTRY
#3155 APOL1 GENOTYPE IS A MAJOR DETERMINANT OF LUPUS NEPHRITIS SEVERITY IN PATIENTS OF AFRICAN ANCESTRY Open
Background and Aims Two polymorphisms of APOL1 gene, G1 and G2, exclusively found among patients of African ancestry, have been associated with chronic kidney disease (CKD) and end-stage kidney disease (ESKD)1. These high-risk polymorphism…
View article: Cardiac toxicity associated with pharmacokinetic drug–drug interaction between crizotinib and sofosbuvir/velpatasvir: A case report
Cardiac toxicity associated with pharmacokinetic drug–drug interaction between crizotinib and sofosbuvir/velpatasvir: A case report Open
This case report describes a pharmacokinetic drug–drug interaction between crizotinib, a tyrosine kinase inhibitor, and sofosbuvir/velpatasvir, a direct‐acting antiviral drug, leading to cardiac toxicity. A 75‐year‐old man, with no cardiov…
View article: Current diagnostic and clinical issues of screening for dihydropyrimidine dehydrogenase deficiency
Current diagnostic and clinical issues of screening for dihydropyrimidine dehydrogenase deficiency Open
View article: Outcomes in kidney transplant recipients treated with immediate‐release tacrolimus capsules versus extended‐release tacrolimus capsules: A cohort study
Outcomes in kidney transplant recipients treated with immediate‐release tacrolimus capsules versus extended‐release tacrolimus capsules: A cohort study Open
Introduction Prior randomized trials and observational studies have generally reported similar outcomes in kidney transplant recipients (KTRs) treated with immediate‐release tacrolimus (IR‐TAC) versus extended‐release tacrolimus (ER‐TAC). …
View article: Impaired fatty acid metabolism perpetuates lipotoxicity along the transition to chronic kidney injury
Impaired fatty acid metabolism perpetuates lipotoxicity along the transition to chronic kidney injury Open
Energy metabolism failure in proximal tubule cells (PTCs) is a hallmark of chronic kidney injury. We combined transcriptomic, metabolomic, and lipidomic approaches in experimental models and patient cohorts to investigate the molecular bas…
View article: Cardiac toxicity associated with pharmacokinetic drug–drug interaction between crizotinib and sofosbuvir/velpatasvir: a case report
Cardiac toxicity associated with pharmacokinetic drug–drug interaction between crizotinib and sofosbuvir/velpatasvir: a case report Open
This case report describes of a pharmacokinetic drug–drug interaction between crizotinib, a tyrosine kinase inhibitor, and sofosbuvir/velpatasvir, a direct-acting antiviral drug, leading to cardiac toxicity. A 75-year-old man, with no card…
View article: Cell stress response impairs de novo NAD+ biosynthesis in the kidney
Cell stress response impairs de novo NAD+ biosynthesis in the kidney Open
The biosynthetic routes leading to de novo nicotinamide adenine dinucleotide (NAD+) production are involved in acute kidney injury (AKI), with a critical role for quinolinate phosphoribosyl transferase (QPRT), a bottleneck enzyme of de nov…
View article: Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction Open
The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has emerged as a promising strategy to promote immune tolerance. However, in conventional T cells (Tconvs), CAR expression is often associated with tonic sign…
View article: Voriconazole pharmacogenetics
Voriconazole pharmacogenetics Open
View article: Marked and prolonged serotonin toxicity in a tramadol-poisoned patient with a pharmacokinetic study
Marked and prolonged serotonin toxicity in a tramadol-poisoned patient with a pharmacokinetic study Open
Marked and prolonged serotonin toxicity was attributed to increased M2 production due to paroxetine- and propranolol-related CYP2D6 inhibition of tramadol metabolism.
View article: Renal Function Decline Under Therapy With Small Interfering RNA Silencing ALAS1 for Acute Intermittent Porphyria
Renal Function Decline Under Therapy With Small Interfering RNA Silencing ALAS1 for Acute Intermittent Porphyria Open
Givosiran is associated with a transient moderate increase in serum creatinine (sCr) without sign of kidney injury. A long-term deleterious impact of ALAS1 inhibition on renal function is not excluded. Because AIP promotes chronic kidney d…
View article: Calcineurin inhibitors nephrotoxicity revisited
Calcineurin inhibitors nephrotoxicity revisited Open
Pallet puts into perspective the new insights offered by Zmijewska et al. (page 2964) into calcineurin inhibitor toxicity that suggest both a biomarker of ongoing cellular injury and therapeutic targets. Pallet puts into perspective the ne…
View article: Artificial increase of uracilemia during fluoropyrimidine treatment can lead to DPD deficiency misinterpretation
Artificial increase of uracilemia during fluoropyrimidine treatment can lead to DPD deficiency misinterpretation Open
View article: Proteinuria and Clinical Outcomes in Hospitalized COVID-19 Patients
Proteinuria and Clinical Outcomes in Hospitalized COVID-19 Patients Open
Background and objectives Kidney involvement is frequent among patients with coronavirus disease 2019 (COVID-19), and occurrence of AKI is associated with higher mortality in this population. The objective of this study was to describe occ…
View article: The spectrum of kidney biopsies in hospitalized patients with COVID-19, acute kidney injury and/or proteinuria
The spectrum of kidney biopsies in hospitalized patients with COVID-19, acute kidney injury and/or proteinuria Open
Background The coronavirus disease 2019 (COVID-19) may be associated with kidney injury, which may impact patient's prognosis. Methods We report a multicentric retrospective case series of patients with COVID-19 who developed acute kidney …
View article: Chemically based transmissible ER stress protocols are unsuitable to study cell-to-cell UPR transmission
Chemically based transmissible ER stress protocols are unsuitable to study cell-to-cell UPR transmission Open
Renal epithelial cells regulate the destructive activity of macrophages and participate in the progression of kidney diseases. Critically, the Unfolded Protein Response (UPR), which is activated in renal epithelial cells in the course of k…
View article: Kidney transplantation improves the clinical outcomes of Acute Intermittent Porphyria
Kidney transplantation improves the clinical outcomes of Acute Intermittent Porphyria Open
View article: De Novo Focal and Segmental Glomerulosclerosis After COVID-19 in a Patient With a Transplanted Kidney From a Donor With a High-risk APOL1 Variant
De Novo Focal and Segmental Glomerulosclerosis After COVID-19 in a Patient With a Transplanted Kidney From a Donor With a High-risk APOL1 Variant Open
Background. There is compelling evidence that renal complications in a native kidney are a major concern in patients infected with severe acute respiratory syndrome coronavirus 2, the causal agent of coronavirus disease 2019 (COVID-19). Th…
View article: Nephrotoxicity Associated With Niraparib
Nephrotoxicity Associated With Niraparib Open
View article: COVID-19–Related Collapsing Glomerulopathy in a Kidney Transplant Recipient
COVID-19–Related Collapsing Glomerulopathy in a Kidney Transplant Recipient Open