Nicolas Rohner
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View article: A study of how the brain immune system responds to powerful forces of cave adaptation in the Mexican tetra 3982
A study of how the brain immune system responds to powerful forces of cave adaptation in the Mexican tetra 3982 Open
Description The Mexican tetra A. mexicanus, with its phenotypically distinct cave- and surface-dwelling conspecific morphs, has provided broad insight into adaptive phenotypes. Recent research highlights the intricate interplay between the…
View article: From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines
From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines Open
Skeletal muscle regeneration depends on muscle stem cells, which give rise to myoblasts that drive muscle growth, repair, and maintenance. In bats—the only mammals capable of powered flight—these processes must also sustain contractile per…
View article: Cave adaptation favors aging resilience in the Mexican tetra
Cave adaptation favors aging resilience in the Mexican tetra Open
All animals age, but the rate of aging across species varies widely. The environmental pressures and molecular factors underlying this remarkable diversity in aging across species remains largely enigmatic. The Mexican tetra, Astyanax mexi…
View article: From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines
From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines Open
Skeletal muscle regeneration depends on muscle stem cells, which give rise to myoblasts that drive muscle growth, repair, and maintenance. In bats—the only mammals capable of powered flight—these processes must also sustain contractile per…
View article: From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines
From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines Open
Skeletal muscle regeneration depends on muscle stem cells, which give rise to myoblasts that drive muscle growth, repair, and maintenance. In bats—the only mammals capable of powered flight—these processes must also sustain contractile per…
View article: Differentially expressed miRNAs offer new perspective into cave adaptation of <i>Astyanax mexicanus</i>
Differentially expressed miRNAs offer new perspective into cave adaptation of <i>Astyanax mexicanus</i> Open
Astyanax mexicanus , a species with both surface‐dwelling and multiple cave‐dwelling populations, offers a unique opportunity to study repeated adaptation to dark and resource‐scarce environments. While previous work has identified large‐s…
View article: Reproductive Adaptation of <i>Astyanax mexicanus</i> Under Nutrient Limitation
Reproductive Adaptation of <i>Astyanax mexicanus</i> Under Nutrient Limitation Open
Reproduction is a fundamental biological process for the survival and continuity of species. Examining changes in reproductive strategies offers valuable insights into how animals have adapted their life histories to different environments…
View article: Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish
Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish Open
Dysregulation of sleep has widespread health consequences and represents an enormous health burden. Short-sleeping individuals are predisposed to the effects of neurodegeneration, suggesting a critical role for sleep in the maintenance of …
View article: Population Genomics of Premature Termination Codons in Cavefish With Substantial Trait Loss
Population Genomics of Premature Termination Codons in Cavefish With Substantial Trait Loss Open
Loss-of-function alleles are a pertinent source of genetic variation with the potential to contribute to adaptation. Cave-adapted organisms exhibit striking loss of ancestral traits such as eyes and pigment, suggesting that loss-of-functio…
View article: Postprandial Sleep in Short‐Sleeping Mexican Cavefish
Postprandial Sleep in Short‐Sleeping Mexican Cavefish Open
Interactions between sleep and feeding behaviors are critical for adaptive fitness. Diverse species suppress sleep when food is scarce to increase the time spent foraging. Postprandial sleep, an increase in sleep time following a feeding e…
View article: Long-term hybridization in a karst window reveals the genetic basis of eye loss in cavefish
Long-term hybridization in a karst window reveals the genetic basis of eye loss in cavefish Open
Eye loss is a hallmark trait of animals inhabiting perpetual darkness, such as caves. The Mexican tetra ( Astyanax mexicanus) provides an unparalleled model for studying the genetic basis of eye loss. There are two interfertile morphs of t…
View article: Divergent 3D genome organization in livers of cave and surface morphs of <i>Astyanax mexicanus</i> as a potential driver of unique metabolic adaptations in cave environment
Divergent 3D genome organization in livers of cave and surface morphs of <i>Astyanax mexicanus</i> as a potential driver of unique metabolic adaptations in cave environment Open
The cave morphs of Astyanax mexicanus have evolved a suite of distinct adaptations to life in perpetual darkness, including the loss of eyes and pigmentation loss, as well as profound metabolic changes such as hyperphagia and starvation re…
View article: A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms
A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms Open
The repeated evolution of similar phenotypes in independent lineages often occurs in response to similar environmental pressures, through similar or different molecular pathways. Recently, a repeatedly occurring mutation R263Q in a conserv…
View article: Sugar assimilation underlying dietary evolution of Neotropical bats
Sugar assimilation underlying dietary evolution of Neotropical bats Open
Dietary specializations in animals lead to adaptations in morphology, anatomy and physiology. Neotropical bats, with their high taxonomic and trophic diversity, offer a unique perspective on diet-driven evolutionary adaptations. Here we as…
View article: Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish
Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish Open
Dysregulation of sleep has widespread health consequences and represents an enormous health burden. Short-sleeping individuals are predisposed to the effects of neurodegeneration, suggesting a critical role for sleep in the maintenance of …
View article: Elevated DNA damage without signs of aging in the short-sleeping Mexican cavefish
Elevated DNA damage without signs of aging in the short-sleeping Mexican cavefish Open
Dysregulated sleep has widespread health consequences, including the accumulation of DNA damage. The Mexican tetra, Astyanax mexicanus , provides a powerful model to study the evolution and consequences of sleep loss. Multiple cave-adapted…
View article: Postprandial sleep in short-sleeping Mexican cavefish
Postprandial sleep in short-sleeping Mexican cavefish Open
Interaction between sleep and feeding behaviors are critical for adaptive fitness. Diverse species suppress sleep when food is scarce to increase the time spent foraging. Post-prandial sleep, an increase in sleep time following a feeding e…
View article: <i>Astyanax mexicanus</i> surface and cavefish chromosome-scale assemblies for trait variation discovery
<i>Astyanax mexicanus</i> surface and cavefish chromosome-scale assemblies for trait variation discovery Open
The ability of organisms to adapt to sudden extreme environmental changes produces some of the most drastic examples of rapid phenotypic evolution. The Mexican Tetra, Astyanax mexicanus, is abundant in the surface waters of northeastern Me…
View article: Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish
Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish Open
Dysregulation of sleep has widespread health consequences and represents an enormous health burden. Short-sleeping individuals are predisposed to the effects of neurodegeneration, suggesting a critical role for sleep in the maintenance of …
View article: Host evolution shapes gut microbiome composition in <i>Astyanax mexicanus</i>
Host evolution shapes gut microbiome composition in <i>Astyanax mexicanus</i> Open
The ecological and genetic changes that underlie the evolution of host–microbe interactions remain elusive, primarily due to challenges in disentangling the variables that alter microbiome composition. To understand the impact of host habi…
View article: Establishing Primary and Stable Cell Lines from Frozen Wing Biopsies for Cellular, Physiological, and Genetic Studies in Bats
Establishing Primary and Stable Cell Lines from Frozen Wing Biopsies for Cellular, Physiological, and Genetic Studies in Bats Open
Bats stand out among mammalian species for their exceptional traits, including the capacity to navigate through flight and echolocation, conserve energy through torpor/hibernation, harbor a multitude of viruses, exhibit resistance to disea…
View article: Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity Open
Starvation causes the accumulation of lipid droplets in the liver, a somewhat counterintuitive phenomenon that is nevertheless conserved from flies to humans. Much like fatty liver resulting from overfeeding, hepatic lipid accumulation (st…
View article: Compartmentalized ocular lymphatic system mediates eye–brain immunity
Compartmentalized ocular lymphatic system mediates eye–brain immunity Open
The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the…
View article: Potential role of microRNAs in regulating transcriptional profile, and sculpting development and metabolism in cavefish
Potential role of microRNAs in regulating transcriptional profile, and sculpting development and metabolism in cavefish Open
Astyanax mexicanus , a species with both surface-dwelling and multiple cave-dwelling populations, offers a unique opportunity to study repeated adaptation to dark and resource-scarce environments. While previous work has identified large-s…
View article: Unraveling stress resilience: Insights from adaptations to extreme environments by <i>Astyanax mexicanus</i> cavefish
Unraveling stress resilience: Insights from adaptations to extreme environments by <i>Astyanax mexicanus</i> cavefish Open
Extreme environmental conditions have profound impacts on shaping the evolutionary trajectory of organisms. Exposure to these conditions elicits stress responses, that can trigger phenotypic changes in novel directions. The Mexican Tetra, …
View article: Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity Open
Starvation causes the accumulation of lipid droplets in the liver, a somewhat counterintuitive phenomenon that is nevertheless conserved from flies to humans. Much like fatty liver resulting from overfeeding, hepatic lipid accumulation (st…
View article: 3D spheroid culturing of <i>Astyanax mexicanus</i> liver‐derived cell lines recapitulates distinct transcriptomic and metabolic states of in vivo tissue environment
3D spheroid culturing of <i>Astyanax mexicanus</i> liver‐derived cell lines recapitulates distinct transcriptomic and metabolic states of in vivo tissue environment Open
In vitro assays are crucial tools for gaining detailed insights into various biological processes, including metabolism. Cave morphs of the river‐dwelling fish species, Astyanax mexicanus , have adapted their metabolism allowing them to th…
View article: Astyanax mexicanus surface and cavefish chromosome-scale assemblies for trait variation discovery
Astyanax mexicanus surface and cavefish chromosome-scale assemblies for trait variation discovery Open
The ability of organisms to adapt to sudden extreme environmental changes produces some of the most drastic examples of rapid phenotypic evolution. The Mexican Tetra, Astyanax mexicanus , is abundant in the surface waters of northeastern M…