Nicolas Simon
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View article: Référentiel de compétences « Méthodologie de Pharmacie Clinique » à destination des enseignants
Référentiel de compétences « Méthodologie de Pharmacie Clinique » à destination des enseignants Open
View article: Emerging mycotoxic syndromes in France: Epidemiological trends and public health implications (2015–2022)
Emerging mycotoxic syndromes in France: Epidemiological trends and public health implications (2015–2022) Open
Mushroom poisoning is a common cause of toxic exposure, and several "new mycotoxic syndromes" have been recognized since the 1990s. We conducted a retrospective multicenter study using the French Poison Control Centers cases database to de…
View article: A preliminary model to tailor osilodrostat in patients with Adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome
A preliminary model to tailor osilodrostat in patients with Adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome Open
Over the past 10 years, osilodrostat has become one of the most commonly used steroidogenesis inhibitors in patients with Cushing's syndrome. The starting dose is usually determined based on the product characteristics, the prescriber's ex…
View article: Trends in antidote use in France from 2015 to 2021: a nationwide poison centers study
Trends in antidote use in France from 2015 to 2021: a nationwide poison centers study Open
View article: Vaginal progesterone and the risk of preterm birth in patients with short cervix beyond 24 weeks
Vaginal progesterone and the risk of preterm birth in patients with short cervix beyond 24 weeks Open
Objective The efficacy of vaginal progesterone (VP) in preventing spontaneous preterm birth (sPTB) among women with a mid‐trimester short cervix is well established. However, data regarding prevention of sPTB using VP beyond 24 weeks are l…
View article: Are plasma drug concentrations still necessary? Rethinking the pharmacokinetic link in dose–response relationships
Are plasma drug concentrations still necessary? Rethinking the pharmacokinetic link in dose–response relationships Open
Plasma drug concentrations have historically played a central role in pharmacology, serving as a measurable intermediary between administered dose and clinical response. This model, linking Dose, Concentration and Effect, underpins therape…
View article: Electrochemistry and nanotechnologies: The new challenges
Electrochemistry and nanotechnologies: The new challenges Open
View article: Response to cabergoline treatment, gonadal axis recovery, and outcomes of drug withdrawal, in men with microprolactinoma: a retrospective cohort study
Response to cabergoline treatment, gonadal axis recovery, and outcomes of drug withdrawal, in men with microprolactinoma: a retrospective cohort study Open
View article: Food Confusion Between Edible and Poisonous Plants: A 22-Year Retrospective of the Southeastern France Poison Control Center
Food Confusion Between Edible and Poisonous Plants: A 22-Year Retrospective of the Southeastern France Poison Control Center Open
Objective: In some regions of the globe, accidental food confusion regarding plants can cause severe poisoning events and deaths. The aim of this study was to report on those confusions from the Marseille Poison Control Centre’s (PCC) expe…
View article: Experimental Model of Ligature-Induced Periodontitis in C57BL/6 Mice
Experimental Model of Ligature-Induced Periodontitis in C57BL/6 Mice Open
Periodontitis is a chronic inflammatory disease that leads to the destruction of the supporting structures of teeth, primarily due to bacterial infection and immune response. The ligature-induced periodontitis (LIP) model is commonly used …
View article: 18 Use of machine learning for dosage individualization of vancomycin in neonates
18 Use of machine learning for dosage individualization of vancomycin in neonates Open
Introduction High variability in vancomycin exposure in neonates requires advanced individualized dosing regimens. Achieving steady-state trough concentration (C0) and steady-state area-under-curve (AUC0-24) targets are important to optimi…
View article: Trends in poisoning associated with the use of insecticides for bed bug infestations: a 20-year retrospective study in France
Trends in poisoning associated with the use of insecticides for bed bug infestations: a 20-year retrospective study in France Open
Bed bugs are pervasive global pests that have reemerged in the last 20 years as a significant public health concern, especially in densely populated urban areas. Beyond financial losses, expenses, inconvenience, and psychological distress,…
View article: Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI
Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI Open
View article: A physiological approach to renal clearance: From premature neonates to adults
A physiological approach to renal clearance: From premature neonates to adults Open
Aims We propose using glomerular filtration rate (GFR) as the physiological basis for distinguishing components of renal clearance. Methods Gentamicin, amikacin and vancomycin are thought to be predominantly excreted by the kidneys. A mixe…
View article: Deliberate Self-Poisoning with Plants in Southeastern France, a Poison Center 20-Year Report
Deliberate Self-Poisoning with Plants in Southeastern France, a Poison Center 20-Year Report Open
Introduction: In a few regions of the globe, deliberate botanical intoxication may induce significant rates of toxicity and fatality. The objective of this report was to describe plant self-intoxication using the experiences of the southea…
View article: Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial
Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial Open
Aims To study the effect of inhaled cannabis on self-assessed predicted driving ability and its relation to reaction times and driving ability on a driving simulator. Participants and methods 30 healthy male volunteers aged 18–34: 15 chron…
View article: Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: involvement of the STN evidenced through Functional Magnetic Resonance Imaging
Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: involvement of the STN evidenced through Functional Magnetic Resonance Imaging Open
Background Addictions often develop in a social context, although the influence of social factors did not receive much attention in the neuroscience of addiction. Recent animal studies suggest that peer presence can reduce cocaine intake, …
View article: Hierarchical Bayesian pharmacometrics analysis of Baclofen for alcohol use disorder
Hierarchical Bayesian pharmacometrics analysis of Baclofen for alcohol use disorder Open
Alcohol use disorder (AUD), also called alcohol dependence, is a major public health problem, affecting almost of the world’s population. Baclofen, as a selective receptor agonist, has emerged as a promising drug for the treatm…
View article: Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials
Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials Open
View article: Sodium Oxybate for Alcohol Dependence: A Network Meta-Regression Analysis Considering Population Severity at Baseline and Treatment Duration
Sodium Oxybate for Alcohol Dependence: A Network Meta-Regression Analysis Considering Population Severity at Baseline and Treatment Duration Open
Aims The estimated effect of sodium oxybate (SMO) in the treatment of alcohol dependence is heterogeneous. Population severity and treatment duration have been identified as potential effect modifiers. Population severity distinguishes hea…
View article: Comparison between Pre-Operative Psychological Stress Induced Change in Hemodynamics with Intubation Stress
Comparison between Pre-Operative Psychological Stress Induced Change in Hemodynamics with Intubation Stress Open
View article: Bayesian Pharmacometrics Analysis of Baclofen for Alcohol Use Disorder
Bayesian Pharmacometrics Analysis of Baclofen for Alcohol Use Disorder Open
Alcohol use disorder (AUD) also called alcohol dependence is a major public health problem, which affects almost 10% of the world’s population. Baclofen as a selective GABA B receptor agonist has emerged as a promising drug for the treatme…
View article: Effect of the first wave of COVID-19 on Poison Control Centre activities in 21 European countries: an EAPCCT initiative
Effect of the first wave of COVID-19 on Poison Control Centre activities in 21 European countries: an EAPCCT initiative Open
Public health emergencies often affect Poison Control Centre (PCC) operations. We examined possible effects of the coronavirus disease 2019 (COVID-19) pandemic on call volume, call characteristics, and workload in European PCCs. All 65 ind…
View article: Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial
Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial Open
Background: Sodium oxybate (SMO) has been shown to be effective in the maintenance of abstinence (MoA) in alcohol-dependent patients in a series of small randomized controlled trials (RCTs). These results needed to be confirmed by a large …
View article: B159 The effect of propofol on ropivacaine-induced central nervous system toxicity in pigs
B159 The effect of propofol on ropivacaine-induced central nervous system toxicity in pigs Open
Background and Aims Ropivacaine is a long-acting local anesthetic, widely used in regional anesthesia. Although less toxic than bupivacaine, ropivacaine has been implicated in the occurrence of central nervous system toxicity. The primary …
View article: Place of the partial dopamine receptor agonist aripiprazole in the management of schizophrenia in adults: a Delphi consensus study
Place of the partial dopamine receptor agonist aripiprazole in the management of schizophrenia in adults: a Delphi consensus study Open
View article: Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application
Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application Open
We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to …
View article: Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta‐regression analysis to develop an enrichment strategy
Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta‐regression analysis to develop an enrichment strategy Open
Background There is considerable unexplained variability in alcohol abstinence rates (AR) in the placebo groups of randomized controlled trials (RCTs) for alcohol dependence (AD). This is of particular interest because placebo responses co…
View article: Ammonia poisoning in drug users, is there an emerging problem?
Ammonia poisoning in drug users, is there an emerging problem? Open
View article: Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction
Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction Open