Nicolás Soler
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Type IV Secretion Systems: Reconciling Diversity Through a Unified Nomenclature Open
Type IV secretion systems (T4SS) are versatile nanomachines responsible for the transfer of DNA and proteins across cell envelopes. From their ancestral role in conjugation, these systems have diversified into a superfamily with functions …
Two OB-fold proteins from a Gram-positive conjugative element engage in relaxosome assembly and DNA processing Open
Integrative and conjugative elements (ICEs) are widespread genomic islands that propagate by bacterial conjugation. ICEs often spread antibiotic resistance genes and other adaptive genes conferring evolutionary advantages to their hosts. A…
View article: Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs
Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs Open
Bacterial type IV secretion systems (T4SSs) are widespread nanomachines specialized in the transport across the cell envelope of various types of molecules including mobile genetic elements during conjugation. Despite their prevalence in G…
Exploration of DNA processing features unravels novel properties of ICE conjugation in Gram-positive bacteria Open
Integrative and conjugative elements (ICEs) are important drivers of horizontal gene transfer in prokaryotes. They are responsible for antimicrobial resistance spread, a major current health concern. ICEs are initially processed by relaxas…
Automation in Latin America: Are Women at Higher Risk of Losing Their Jobs? Open
New technological trends, such as digitization, artificial intelligence and robotics, have the power to drastically increase economic output but may also displace workers. In this paper we assess the risk of automation for female and male …
Extracellular membrane vesicles and nanotubes in Archaea Open
Membrane-bound extracellular vesicles (EVs) are secreted by cells from all three domains of life and their implication in various biological processes is increasingly recognized. In this review, we summarize the current knowledge on archae…
Search for asymptomatic carriers of SARS-CoV-2 in healthcare workers during the pandemic: a Spanish experience Open
Summary Background Asymptomatic carriers of SARS-CoV-2 can be a vehicle for transmission of the infection. This fact is of particular importance in the case of healthcare workers (HCWs). Design Cross-sectional study in HCWs in a medium siz…
The coordination of spindle-positioning forces during the asymmetric division of the <i>C. elegans</i> zygote is revealed by distinct microtubule dynamics at the cortex Open
In the Caenorhabditis elegans zygote, astral microtubules generate forces, pushing against and pulling from the cell periphery. They are essential to position the mitotic spindle. By measuring the dynamics of astral microtubules at the cor…
Characterization of a relaxase belonging to the MOBT family, a widespread family in Firmicutes mediating the transfer of ICEs Open
All together, this work argues in favor of MOBT being a full family of non-canonical relaxases. The biochemical and structural characterization of a MOBT member provides new insights on the molecular mechanism of conjugative transfer media…
Additional file 2: of Characterization of a relaxase belonging to the MOBT family, a widespread family in Firmicutes mediating the transfer of ICEs Open
Figure S2. Sequence alignment of MOBT relaxase and Rep_trans RCR initiators. This larger alignment with more MOBT and Rep_trans initiator sequences illustrates the conservation of the motifs through very distant proteins. See complete lege…
Additional file 1: of Characterization of a relaxase belonging to the MOBT family, a widespread family in Firmicutes mediating the transfer of ICEs Open
Figure S1. Alignment of MOBT relaxase representatives with Rep_trans RCR initiator representatives. This alignment with reduced number of sequences allows the identification of the different motifs cited in this study. See complete legend …