Nicolas Van Larebeke
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View article: Associations between exposure to metals, chlorinated pesticides, and PCBs and differential leukocyte profiles in Flemish adolescents
Associations between exposure to metals, chlorinated pesticides, and PCBs and differential leukocyte profiles in Flemish adolescents Open
Although environmental pollutants are known to affect the immune system, the impact of chemical mixtures on adolescent immune function remains understudied. Adolescence is a critical period for immune maturation, and disruptions during thi…
View article: Per- and polyfluoroalkyl substances (PFAS), thyroid hormones, sexual hormones and pubertal development in adolescents residing in the neighborhood of a 3M factory
Per- and polyfluoroalkyl substances (PFAS), thyroid hormones, sexual hormones and pubertal development in adolescents residing in the neighborhood of a 3M factory Open
We observed significant, consistent and biologically relevant associations of PFAS serum concentrations with sex hormone and SHBG levels in male adolescents. Moreover, a significant delay in physiological processes occurring in puberty was…
View article: The Association between Chemical Mixture Exposure and Differential Leukocytes in Flemish Adolescents
The Association between Chemical Mixture Exposure and Differential Leukocytes in Flemish Adolescents Open
View article: The Association between Chemical Mixture Exposure and Differential Leukocytes in Flemish Adolescents
The Association between Chemical Mixture Exposure and Differential Leukocytes in Flemish Adolescents Open
View article: Organic food and internal exposure to pollutants among Flemish adolescents
Organic food and internal exposure to pollutants among Flemish adolescents Open
Contrary to the initial hypothesis, Flemish adolescents who reported consuming organic food at least 7.5 times per week did not exhibit reduced internal exposure to the tested recently used pesticides. After adjustment for gender, age, cou…
View article: Intake Rates of Methylmercury in the Belgian Population: Evolution Over 40 Years
Intake Rates of Methylmercury in the Belgian Population: Evolution Over 40 Years Open
View article: Intake Rates of Methylmercury in the Belgian Population: Evolution Over 40 Years
Intake Rates of Methylmercury in the Belgian Population: Evolution Over 40 Years Open
View article: Protecting public health and the environment: towards a general ban on cellulose acetate cigarette filters in the European Union
Protecting public health and the environment: towards a general ban on cellulose acetate cigarette filters in the European Union Open
After the establishment of a causal relationship between tobacco use and cancer in the 1950s, cellulose acetate filters were introduced with the claim to reduce the adverse health impact of unfiltered cigarettes. Often perceived to be more…
View article: PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies
PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies Open
Early puberty has been found to be associated with adverse health outcomes such as metabolic and cardiovascular diseases and hormone-dependent cancers. The decrease in age at menarche observed during the past decades has been linked to an …
View article: Balancing Acute and Chronic Occupational Risks: The Use of Nitrile Butadiene Rubber Undergloves by Firefighters to Reduce Exposure to Toxic Contaminants
Balancing Acute and Chronic Occupational Risks: The Use of Nitrile Butadiene Rubber Undergloves by Firefighters to Reduce Exposure to Toxic Contaminants Open
Firefighters are exposed via multi-route exposure to a multitude of chemicals (PAHs, VOCs, flame retardants, dioxins, etc.) that may cause acute and long-term health effects. The dermal absorption of contaminants is a major contributor to …
View article: Per- and polyfluoroalkyl substances (PFAS) and immune system-related diseases: results from the Flemish Environment and Health Study (FLEHS) 2008–2014
Per- and polyfluoroalkyl substances (PFAS) and immune system-related diseases: results from the Flemish Environment and Health Study (FLEHS) 2008–2014 Open
View article: Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)
Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS) Open
View article: Internal exposure of Flemish teenagers to environmental pollutants: Results of the Flemish Environment and Health Study 2016–2020 (FLEHS IV)
Internal exposure of Flemish teenagers to environmental pollutants: Results of the Flemish Environment and Health Study 2016–2020 (FLEHS IV) Open
The Flemish Environment and Health Study (FLEHS) collects information on internal exposure to a broad range of environmental chemicals in the general population in Flanders, the Northern region of Belgium. The aim is to establish biomonito…
View article: Determinants of Chronic Biological Stress, Measured as Hair Cortisol Concentration, in a General Population of Adolescents: From Individual and Household Characteristics to Neighborhood Urbanicity
Determinants of Chronic Biological Stress, Measured as Hair Cortisol Concentration, in a General Population of Adolescents: From Individual and Household Characteristics to Neighborhood Urbanicity Open
Chronic biological stress may adversely affect adolescents' physical and mental health, but insight in the personal and environmental factors that determine chronic stress is limited. We measured 3-month cumulative hair cortisol concentrat…
View article: Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents: FLEHS-4 (2016–2020)
Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents: FLEHS-4 (2016–2020) Open
Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants of public health concern. Multiple biological mechanisms have been hypothesized to contribute to PAHs-associated adverse health effects. Little is known about the impact …
View article: Long-term residential exposure to air pollution is associated with hair cortisol concentration and differential leucocyte count in Flemish adolescent boys
Long-term residential exposure to air pollution is associated with hair cortisol concentration and differential leucocyte count in Flemish adolescent boys Open
View article: Human Biomonitoring Data Enables Evidence-Informed Policy to Reduce Internal Exposure to Persistent Organic Compounds: A Case Study
Human Biomonitoring Data Enables Evidence-Informed Policy to Reduce Internal Exposure to Persistent Organic Compounds: A Case Study Open
Human biomonitoring (HBM) monitors levels of environmental pollutants in human samples, which often is a topic of concern for residents near industrially contaminated sites (ICSs). Around an ICS area in Menen (Belgium), including a (former…
View article: Participant Experiences in a Human Biomonitoring Study: Follow-Up Interviews with Participants of the Flemish Environment and Health Study
Participant Experiences in a Human Biomonitoring Study: Follow-Up Interviews with Participants of the Flemish Environment and Health Study Open
Communicating individual human biomonitoring results to study participants has been the subject of debate for some time. This debate is dominated by ethical considerations from a researchers’ perspective on whether or not to communicate, t…
View article: Neurobehavioural and cognitive effects of prenatal exposure to organochlorine compounds in three year old children
Neurobehavioural and cognitive effects of prenatal exposure to organochlorine compounds in three year old children Open
View article: Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14–15 years) from the Flemish Environment and Health Study
Exposure levels, determinants and risk assessment of organophosphate flame retardants and plasticizers in adolescents (14–15 years) from the Flemish Environment and Health Study Open
View article: Breastfeeding predicts blood mitochondrial DNA content in adolescents
Breastfeeding predicts blood mitochondrial DNA content in adolescents Open
Nutrition during early childhood is linked to metabolic programming. We hypothesized that breastfeeding has long-term consequences on the energy metabolism exemplified by mitochondrial DNA (mtDNA). As part of the third cycle of the Flemish…
View article: Perfluorinated substances in the Flemish population (Belgium): Levels and determinants of variability in exposure
Perfluorinated substances in the Flemish population (Belgium): Levels and determinants of variability in exposure Open
View article: Health risks related to seafood consumption and arsenic speciation in fish and shellfish from North Sea (Southern Bight) and Açu Port area (Brazil)
Health risks related to seafood consumption and arsenic speciation in fish and shellfish from North Sea (Southern Bight) and Açu Port area (Brazil) Open
In both the North Sea and the Açu Port (Brazil) coastal areas, high As concentrations were observed in water, soil and sediments. Therefore, the impact of this contamination on fish and shellfish species bought from local fishermen was stu…
View article: Rationale for Environmental Hygiene towards global protection of fetuses and young children from adverse lifestyle factors
Rationale for Environmental Hygiene towards global protection of fetuses and young children from adverse lifestyle factors Open
View article: Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure
Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure Open
View article: Three cycles of human biomonitoring in Flanders − Time trends observed in the Flemish Environment and Health Study
Three cycles of human biomonitoring in Flanders − Time trends observed in the Flemish Environment and Health Study Open
View article: Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women
Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women Open
Expression of the sex-specific candidate genes identified in the discovery population predicted PM10 exposure in an independent cohort of adults from the same area. Confirmation in other populations may further support this as a…
View article: Combined Effects of Prenatal Exposures to Environmental Chemicals on Birth Weight
Combined Effects of Prenatal Exposures to Environmental Chemicals on Birth Weight Open
Prenatal chemical exposure has been frequently associated with reduced fetal growth by single pollutant regression models although inconsistent results have been obtained. Our study estimated the effects of exposure to single pollutants an…
View article: Distinct genotype-dependent differences in transcriptome responses in humans exposed to environmental carcinogens
Distinct genotype-dependent differences in transcriptome responses in humans exposed to environmental carcinogens Open
Considering genetic variability in population studies focusing on the health risk assessment of exposure to environmental carcinogens may provide improved insights in individual environmental cancer risks. Therefore, the current study aims…
View article: Causes of genome instability: the effect of low dose chemical exposures in modern society
Causes of genome instability: the effect of low dose chemical exposures in modern society Open
Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to environmental …