Nicole Bitsch
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View article: Vascular contribution to cognitive impairment in heart failure with preserved ejection fraction: TRPV4 and KLF2 as key mediators of neurovascular dysfunction in the ZSF1 model
Vascular contribution to cognitive impairment in heart failure with preserved ejection fraction: TRPV4 and KLF2 as key mediators of neurovascular dysfunction in the ZSF1 model Open
Background The development of vascular cognitive impairment (VCI) and heart failure with preserved ejection fraction (HFpEF) are strongly associated with comorbidities such as obesity, diabetes, hypertension, and aging. Microvascular dysfu…
View article: Effect of rapid cooling, frozen storage, and thawing on the passive viscoelastic properties and structure of the rat aorta
Effect of rapid cooling, frozen storage, and thawing on the passive viscoelastic properties and structure of the rat aorta Open
Biological tissues decay over time after harvesting, which alters their biomechanical properties. This poses logistical challenges for studies investigating passive arterial biomechanics as tissues need to be characterized shortly after ex…
View article: Evaluating flash freezing for preservation of rat abdominal aorta for delayed biomechanical characterization
Evaluating flash freezing for preservation of rat abdominal aorta for delayed biomechanical characterization Open
Most studies investigating arterial stiffening use animal rather than human arteries. This is because human tissue becomes available in small amounts and at irregular times, which complicates planning of experimental work. Suitable tissue …
View article: Molecular Detection of Venous Thrombosis in Mouse Models Using SPECT/CT
Molecular Detection of Venous Thrombosis in Mouse Models Using SPECT/CT Open
The efficacy of thrombolysis is inversely correlated with thrombus age. During early thrombogenesis, activated factor XIII (FXIIIa) cross-links α2-AP to fibrin to protect it from early lysis. This was exploited to develop an α2-AP-based im…
View article: Comparison of different chemically modified inhibitors of miR-199b in vivo
Comparison of different chemically modified inhibitors of miR-199b in vivo Open
MicroRNAs (miRNAs) have recently received great attention for their regulatory roles in diverse cellular processes and for their contribution to several human pathologies. Modulation of miRNAs in vivo provides beneficial therapeutic strate…
View article: Microvascular Angina: Diagnosis and Treatment Particularities61MicroRNA-216a: a cardiac-specific post-transcriptional regulator of capillary rarefaction associated with heart failure62Divergent effects of pre- and post-conditioning on microvascular function63Tissue factor variants induce monocyte mobilization and transdifferentiation into endothelial-like cells that promote angiogenesis
Microvascular Angina: Diagnosis and Treatment Particularities61MicroRNA-216a: a cardiac-specific post-transcriptional regulator of capillary rarefaction associated with heart failure62Divergent effects of pre- and post-conditioning on microvascular function63Tissue factor variants induce monocyte mobilization and transdifferentiation into endothelial-like cells that promote angiogenesis Open
Background: While cardiomyocytes have been the main subject of extensive research in the past, the role of other cardiac cell types in the pathogenesis of heart failure received considerable less attention. Multiple other cell types, inclu…
View article: Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice
Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice Open
These findings confirm a role for the lncRNA Malat-1 in mRNA splicing. However, no critical role for Malat-1 was found in pressure overload-induced heart failure in mice, despite its reported role in vascularization, ERK/MAPK signaling, an…
View article: Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis Open
Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial vessels. However, the role of VSMC autophagy in cardiovascular disease is poorly understood. Therefore, we investigated the effect of defective autophagy o…