Nicole E. Burma
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View article: Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry
Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry Open
Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to disconti…
View article: A dynamic role for dopamine receptors in the control of mammalian spinal networks
A dynamic role for dopamine receptors in the control of mammalian spinal networks Open
Dopamine is well known to regulate movement through the differential control of direct and indirect pathways in the striatum that express D 1 and D 2 receptors respectively. The spinal cord also expresses all dopamine receptors however; ho…
View article: Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain
Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain Open
Pain is a multidimensional experience and negative affect, or how much the pain is “bothersome”, significantly impacts the sufferers' quality of life. It is well established that the κ opioid system contributes to depressive and dysphoric …
View article: Microglial pannexin-1 channel activation is a spinal determinant of joint pain
Microglial pannexin-1 channel activation is a spinal determinant of joint pain Open
A new therapeutic option for treating arthritis pain.
View article: Microglial pannexin-1 is a cellular determinant of opioid withdrawal
Microglial pannexin-1 is a cellular determinant of opioid withdrawal Open
Opioid analgesics are indispensable for treating acute post-operative pain, and a variety of chronic pain conditions. However, an over-reliance on opioids can put individuals at risk of developing severe side effects. For chronic opioid us…
View article: Therapies and Mechanisms of Opioid Withdrawal
Therapies and Mechanisms of Opioid Withdrawal Open
The recent identification of novel cellular substrates of opioid withdrawal that are blocked by clinically approved drugs brings the promise of much needed new therapies.
View article: Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance
Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance Open
Tolerance to the analgesic effects of opioids is a major problem in chronic pain management. Microglia are implicated in opioid tolerance, but the core mechanisms regulating their response to opioids remain obscure. By selectively ablating…
View article: Genetic deletion of microglial Panx1 attenuates morphine withdrawal, but not analgesic tolerance or hyperalgesia in mice
Genetic deletion of microglial Panx1 attenuates morphine withdrawal, but not analgesic tolerance or hyperalgesia in mice Open
Opioids are among the most powerful analgesics for managing pain, yet their repeated use can lead to the development of severe adverse effects. In a recent study, we identified the microglial pannexin-1 channel (Panx1) as a critical substr…
View article: Erratum: Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents
Erratum: Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents Open
Nat. Med.; 10.1038/nm.4281; corrected online 15 February 2017 In the version of this article initially published online, Yves De Koninck's name was misspelled in the author list. The original version listed Yves DeKoninck. The error has be…