Nicole L. Mendell
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View article: Survey of Fleas and Ticks for Rickettsia rickettsii and Rickettsia typhi in the El Paso Community and Other Areas in Texas, New Mexico, and Ciudad Juarez, Mexico
Survey of Fleas and Ticks for Rickettsia rickettsii and Rickettsia typhi in the El Paso Community and Other Areas in Texas, New Mexico, and Ciudad Juarez, Mexico Open
This survey was conducted with the aim of determining the public health risk of Rocky Mountain spotted fever and murine typhus in the urban and peri-urban areas of El Paso, as well as other areas in Texas, southern New Mexico, and Ciudad J…
View article: Rickettsia parkeri Rickettsiosis Resembling Sweet Syndrome: A Differential Diagnosis for Critical Discussion
Rickettsia parkeri Rickettsiosis Resembling Sweet Syndrome: A Differential Diagnosis for Critical Discussion Open
Introduction: Spotted fever group (SFG) rickettsioses are tick-transmitted infections caused by Gram-negative, obligately intracellular bacteria in the genus Rickettsia. They present as an acute undifferentiated febrile illness, and they a…
View article: Science abhors a surveillance vacuum: Detection of ticks and tick-borne pathogens in southern New Mexico through passive surveillance
Science abhors a surveillance vacuum: Detection of ticks and tick-borne pathogens in southern New Mexico through passive surveillance Open
Robust tick surveillance enhances diagnosis and prevention of tick-borne pathogens, yet surveillance efforts in the United States are highly uneven, resulting in large surveillance vacuums, one of which spans the state of New Mexico. As pa…
View article: Science abhors a surveillance vacuum: detection of ticks and tick-borne bacteria in southern New Mexico through passive surveillance
Science abhors a surveillance vacuum: detection of ticks and tick-borne bacteria in southern New Mexico through passive surveillance Open
Robust tick surveillance enhances diagnosis and prevention of tick-borne pathogens, yet surveillance efforts in the U.S. are highly uneven, resulting in large surveillance vacuums, one of which spans the state of New Mexico. As part of a l…
View article: First isolation of Rickettsia amblyommatis from Amblyomma mixtum in Colombia
First isolation of Rickettsia amblyommatis from Amblyomma mixtum in Colombia Open
View article: Spotted Fever and Typhus Group Rickettsiae in Dogs and Humans, Mexico, 2022
Spotted Fever and Typhus Group Rickettsiae in Dogs and Humans, Mexico, 2022 Open
We found serologic evidence of spotted fever group Rickettsia in humans and dogs and typhus group Rickettsia in dogs in Reynosa, Mexico. Our investigation revealed serologic samples reactive to spotted fever group Rickettsia in 5 community…
View article: A scrub typhus vaccine presents a challenging unmet need
A scrub typhus vaccine presents a challenging unmet need Open
Scrub typhus caused by the obligately intracellular bacterium, Orientia tsutsugamushi , is a major cause of life-threatening acute undifferentiated febrile illness in eastern Asia and the islands of the Western Pacific and Indian oceans. S…
View article: Increased Seroprevalence of Typhus Group Rickettsiosis, Galveston County, Texas, USA
Increased Seroprevalence of Typhus Group Rickettsiosis, Galveston County, Texas, USA Open
Whether increases in typhus group rickettsiosis in Galveston County, Texas, USA, are caused by increased recognition or true reemergence is unclear. We conducted a serosurvey that demonstrated Rickettsia typhi antibodies increased from 1.2…
View article: Genetic characterization of a novel Ehrlichia chaffeensis genotype from an Amblyomma tenellum tick from South Texas, USA
Genetic characterization of a novel Ehrlichia chaffeensis genotype from an Amblyomma tenellum tick from South Texas, USA Open
View article: Experimental Rickettsia typhi Infection in Monodelphis domestica: Implications for Opossums as an Amplifying Host in the Suburban Cycle of Murine Typhus
Experimental Rickettsia typhi Infection in Monodelphis domestica: Implications for Opossums as an Amplifying Host in the Suburban Cycle of Murine Typhus Open
Murine typhus is an acute undifferentiated febrile illness caused by Rickettsia typhi . In the United States, its reemergence appears to be driven by a shift from the classic rat–rat flea cycle of transmission to one involving opossums ( D…
View article: A Murine Model of Waning Scrub Typhus Cross-Protection between Heterologous Strains of Orientia tsutsugamushi
A Murine Model of Waning Scrub Typhus Cross-Protection between Heterologous Strains of Orientia tsutsugamushi Open
Orientia tsutsugamushi, the etiologic agent of the life-threatening febrile disease scrub typhus, is an obligately intracellular small coccobacillary bacterium belonging to the family Rickettsiaceae and is transmitted by the parasitic larv…
View article: Mechanisms of Sporicidal Activity Induced by Ionized Hydrogen Peroxide in the Spores of <i>Bacillus atrophaeus</i>
Mechanisms of Sporicidal Activity Induced by Ionized Hydrogen Peroxide in the Spores of <i>Bacillus atrophaeus</i> Open
Introduction: Ionized hydrogen peroxide (iHP) is a new technology used for the decontamination of surfaces or laboratory areas. It utilizes a low concentration of hydrogen peroxide (H2O2) mixed with air and ion…
View article: Detection of Rickettsiae, Borreliae, and Ehrlichiae in Ticks Collected from Walker County, Texas, 2017–2018
Detection of Rickettsiae, Borreliae, and Ehrlichiae in Ticks Collected from Walker County, Texas, 2017–2018 Open
Cases of tick-borne diseases, including spotted fever rickettsioses, borreliosis, babesiosis, anaplasmosis and ehrlichiosis, in the United States and territories have more than doubled from 2004 to 2016 and account for 77% of all vector-bo…
View article: Whole-Genome Sequence of Rickettsia parkeri Strain Atlantic Rainforest, Isolated from a Colombian Tick
Whole-Genome Sequence of Rickettsia parkeri Strain Atlantic Rainforest, Isolated from a Colombian Tick Open
Rickettsia parkeri is classified as a member of the alphaproteobacterial microorganisms, genus Rickettsia . Here, we report the complete genome sequence of Rickettsia parkeri strain Atlantic Rainforest, which was isolated from an Amblyomma…
View article: A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain
A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain Open
Since R. parkeri is used at biosafety level 2, the greatest advantage of this inbred mouse model is the ability to investigate immunity and pathogenesis of rickettsiosis with all the tools available at biosafety level 2.
View article: A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest-like isolate
A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest-like isolate Open
Background The species of the Rickettsia genus is separated into four groups: the ancestral group, typhus group, transitional group and spotted fever group. Rickettsia parkeri, a spotted fever group Rickettsia, has been reported across the…
View article: Correction: CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection
Correction: CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection Open
[This corrects the article DOI: 10.1371/journal.pntd.0005763.].
View article: CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection
CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection Open
[This corrects the article DOI: 10.1371/journal.pntd.0005763.].
View article: Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection
Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection Open
These models parallel characteristics of human cases of scrub typhus, and will be used in concert to understand differences in severity which lead to lethality or host control of the infection and to address the explanation for short durat…
View article: An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection
An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection Open
Scrub typhus is a neglected tropical disease, caused by Orientia tsutsugamushi, a Gram-negative bacterium that is transmitted to mammalian hosts during feeding by Leptotrombidium mites and replicates predominantly within endothelial cells.…
View article: Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee
Human Infections by Multiple Spotted Fever Group Rickettsiae in Tennessee Open
Rocky Mountain spotted fever is the most common tick-borne disease in Tennessee. However, Rickettsia rickettsii has rarely been isolated from endemic ticks, suggesting rickettsioses may be caused by other species. A total of 56 human serum…
View article: IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice
IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice Open
Endothelial cells (EC) are the main target for Orientia tsutsugamushi infection and EC dysfunction is a hallmark of severe scrub typhus in patients. However, the molecular basis of EC dysfunction and its impact on infection outcome are poo…