Nicole Monroe
YOU?
Author Swipe
View article: 531. Clinical Evaluation of the BioFire® FilmArray® Gastrointestinal (GI) Panel for use with Rectal Swab Specimens in Cary-Blair Media
531. Clinical Evaluation of the BioFire® FilmArray® Gastrointestinal (GI) Panel for use with Rectal Swab Specimens in Cary-Blair Media Open
Background The BioFire® FilmArray® Gastrointestinal (GI) Panel provides results for 22 bacterial, viral, and protozoan pathogens responsible for GI infection in about an hour. This test is indicated for use with stool specimens in Cary-Bla…
View article: Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation
Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation Open
Many members of the AAA+ ATPase family function as hexamers that unfold their protein substrates. These AAA unfoldases include spastin, which plays a critical role in the architecture of eukaryotic cells by driving the remodeling and sever…
View article: The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets
The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets Open
The hexameric AAA ATPase Vps4 drives membrane fission by remodeling and disassembling ESCRT-III filaments. Building upon our earlier 4.3 Å resolution cryo-EM structure (Monroe et al., 2017), we now report a 3.2 Å structure of Vps4 bound to…
View article: Author response: The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets
Author response: The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets Open
View article: Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase Open
Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with it…
View article: Author response: Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
Author response: Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase Open
Article Figures and data Abstract eLife digest Introduction Results and discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Many important cellular m…
View article: Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines
Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines Open
View article: Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs)
Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs) Open