Nicole N. Haese
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View article: An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation
An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation Open
Introduction RNA sequencing (RNA-seq) can measure whole transcriptome gene expression from tissues or even individual cells, providing a powerful tool to study the immune response. Analysis of RNA-seq data involves mapping relatively short…
View article: Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model
Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model Open
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR)…
View article: Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection
Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection Open
Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use. Mayaro virus (MAYV) is a related emerging alphavirus with epidemic potential …
View article: Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection
Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection Open
Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use. Mayaro virus (MAYV) is a related emerging alphavirus with epidemic potential …
View article: Mayaro virus pathogenesis and immunity in rhesus macaques
Mayaro virus pathogenesis and immunity in rhesus macaques Open
Mayaro virus (MAYV) is a mosquito-transmitted alphavirus that causes debilitating and persistent arthritogenic disease. While MAYV was previously reported to infect non-human primates (NHP), characterization of MAYV pathogenesis is current…
View article: Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein
Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein Open
Infections with Chikungunya virus, a mosquito-borne alphavirus, cause an acute febrile syndrome often followed by chronic arthritis that persists for months to years post-infection. Neutralizing antibodies are the primary immune correlate …
View article: Differential Type 1 IFN Gene Expression in CD14+ Placenta Cells Elicited by Zika Virus Infection During Pregnancy
Differential Type 1 IFN Gene Expression in CD14+ Placenta Cells Elicited by Zika Virus Infection During Pregnancy Open
Zika virus (ZIKV) is an arthropod-borne Flavivirus that can also be transmitted vertically from infected mother to fetus. Infection of the fetus during pregnancy can lead to congenital malformations and severely impact fetal brain developm…
View article: Fetal Central Nervous System Derived Extracellular Vesicles: Potential for Non-invasive Tracking of Viral Mediated Fetal Brain Injury
Fetal Central Nervous System Derived Extracellular Vesicles: Potential for Non-invasive Tracking of Viral Mediated Fetal Brain Injury Open
Introduction: Extracellular vesicles derived from the fetal central nervous system (FCNSEs) can be purified from maternal serum or plasma using the protein Contactin-2/TAG1that is expressed almost exclusively by developing neurons in the h…
View article: Nonhuman Primate Models of Zika Virus Infection and Disease during Pregnancy
Nonhuman Primate Models of Zika Virus Infection and Disease during Pregnancy Open
Since the explosive outbreak of Zika virus in Brazil and South/Central America in 2015–2016, the frequency of infections has subsided, but Zika virus remains present in this region as well as other tropical and sub-tropical areas of the gl…
View article: Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus
Identification of Quinolinones as Antivirals against Venezuelan Equine Encephalitis Virus Open
Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a high-throughput cell-based screen, we identified a quinolinone compound that prot…
View article: Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors
Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors Open
A benzo[6]annulene, 4-(tert-butyl)-N-(3-methoxy-5,6,7,8-tetrahydronaphthalen-2-yl) benzamide (1a), was identified as an inhibitor against Chikungunya virus (CHIKV) with antiviral activity EC90 = 1.45 μM and …
View article: Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses
Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses Open
Mayaro virus (MAYV) is an alphavirus endemic to South and Central America associated with sporadic outbreaks in humans. MAYV infection causes severe joint and muscle pain that can persist for weeks to months. Currently, there are no approv…
View article: Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design
Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design Open
The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence. No small molecule drugs targeting CHIK…
View article: Rat Cytomegalovirus Virion-Associated Proteins R131 and R129 Are Necessary for Infection of Macrophages and Dendritic Cells
Rat Cytomegalovirus Virion-Associated Proteins R131 and R129 Are Necessary for Infection of Macrophages and Dendritic Cells Open
Cytomegalovirus (CMV) establishes persistent, latent infection in hosts, causing diseases in immunocompromised patients, transplant recipients, and neonates. CMV infection modifies the host chemokine axis by modulating chemokine and chemok…
View article: Macrophage depletion of CMV latently infected donor hearts ameliorates recipient accelerated chronic rejection
Macrophage depletion of CMV latently infected donor hearts ameliorates recipient accelerated chronic rejection Open
Cytomegalovirus (CMV) infection is linked to acceleration of solid organ transplant vascular sclerosis (TVS) and chronic rejection (CR). Donor latent CMV infection increases cardiac‐resident macrophages and T cells leading to increased inf…
View article: Blocking the IL-1 receptor reduces cardiac transplant ischemia and reperfusion injury and mitigates CMV-accelerated chronic rejection
Blocking the IL-1 receptor reduces cardiac transplant ischemia and reperfusion injury and mitigates CMV-accelerated chronic rejection Open
Ischemia-reperfusion injury (IRI) is an important risk factor for accelerated cardiac allograft rejection and graft dysfunction . Utilizing a rat heart isogeneic transplant model, we identified inflammatory pathways involved in IRI in orde…
View article: Vaccine-induced skewing of t cell responses protects against chikungunya virus disease
Vaccine-induced skewing of t cell responses protects against chikungunya virus disease Open
Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, th…
View article: Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus
Studies on Dibenzylamines as Inhibitors of Venezuelan Equine Encephalitis Virus Open
Alphaviruses are arthropod-transmitted members of the Togaviridae family that can cause severe disease in humans, including debilitating arthralgia and severe neurological complications. Currently, there are no approved vaccines or antivir…
View article: Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway
Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway Open
The type I interferon (IFN) system represents an essential innate immune response that renders cells resistant to virus growth via the molecular actions of IFNinduced effector proteins. IFN-mediated cellular states inhibit growth of numero…
View article: Animal Models of Chikungunya Virus Infection and Disease
Animal Models of Chikungunya Virus Infection and Disease Open
Chikungunya virus (CHIKV) is a reemerging alphavirus that causes acute febrile illness and severe joint pain in humans. Although acute symptoms often resolve within a few days, chronic joint and muscle pain can be long lasting. In the last…
View article: A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy
A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy Open
Zika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformatio…
View article: Small Molecule Inhibitors Targeting Chikungunya Virus
Small Molecule Inhibitors Targeting Chikungunya Virus Open
View article: Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease
Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease Open
Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, th…
View article: Risk of Zika microcephaly correlates with features of maternal antibodies
Risk of Zika microcephaly correlates with features of maternal antibodies Open
Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other f…
View article: Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology Open
View article: Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway
Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway Open
The type I interferon (IFN) system represents an essential innate immune response that renders cells resistant to virus growth via the molecular actions of IFN-induced effector proteins. IFN-mediated cellular states inhibit growth of numer…
View article: Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques
Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques Open
Chikungunya virus (CHIKV) is a mosquito-borne virus that causes a febrile syndrome in humans associated with acute and chronic debilitating joint and muscle pain. Currently no licensed vaccines or therapeutics are available to prevent or t…
View article: Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues Open
[This corrects the article DOI: 10.1371/journal.ppat.1006219.].
View article: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues Open
Zika virus (ZIKV), an emerging flavivirus, has recently spread explosively through the Western hemisphere. In addition to symptoms including fever, rash, arthralgia, and conjunctivitis, ZIKV infection of pregnant women can cause microcepha…
View article: Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months Open