Nicole Rübsamen
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View article: Merging Adaptive Designs with Dynamic Infectious Disease Models Allows Faster and more Accurate Diagnostic Test Accuracy Studies in the Case of an Epidemic
Merging Adaptive Designs with Dynamic Infectious Disease Models Allows Faster and more Accurate Diagnostic Test Accuracy Studies in the Case of an Epidemic Open
Background During epidemics with emerging infections, diagnostic tests directly inform model-based decision-making and thereby shape infection control strategies. However, diagnostic accuracy studies (DTA) assessing the validity of these t…
View article: A multi-analyst study on the influence of marital status on the incidence of cardiovascular disease
A multi-analyst study on the influence of marital status on the incidence of cardiovascular disease Open
Introduction Multi-analyst studies, in which several analysts use the same data to independently investigate identical research questions, are rarely done in public health. The present analysis was based on the research question: “Does mar…
View article: Statistical methods for the analysis of diagnostic test accuracy in clustered data settings - A protocol for a systematic review of methods
Statistical methods for the analysis of diagnostic test accuracy in clustered data settings - A protocol for a systematic review of methods Open
View article: A rule-based clinical decision support system for detection of acute kidney injury after pediatric cardiac surgery
A rule-based clinical decision support system for detection of acute kidney injury after pediatric cardiac surgery Open
We demonstrated that a CDSS is able to perform a complex AKI detection and staging process, including 11 criteria across three stages. For accurate automated AKI detection, standardized machine-readable data of high data quality are requir…
View article: Changes in social contact patterns in Germany during the SARS-CoV-2 pandemic – an analysis based on the COVIMOD study
Changes in social contact patterns in Germany during the SARS-CoV-2 pandemic – an analysis based on the COVIMOD study Open
View article: Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS
Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS Open
There is a substantial variation in susceptibility to ARIs in childhood, which is not explained by exposure factors.
View article: A unified framework for diagnostic test development and evaluation during outbreaks of emerging infections
A unified framework for diagnostic test development and evaluation during outbreaks of emerging infections Open
View article: Plasma immune signatures can predict rejection-free survival in the first year after pediatric liver transplantation
Plasma immune signatures can predict rejection-free survival in the first year after pediatric liver transplantation Open
View article: Corrigendum to “The impact of inaccurate assumptions about antibody test accuracy on the parametrisation and results of infectious disease models of epidemics” [Epidemics 46 (2024) 100741]
Corrigendum to “The impact of inaccurate assumptions about antibody test accuracy on the parametrisation and results of infectious disease models of epidemics” [Epidemics 46 (2024) 100741] Open
View article: Diagnostic test accuracy in longitudinal study settings: theoretical approaches with use cases from clinical practice
Diagnostic test accuracy in longitudinal study settings: theoretical approaches with use cases from clinical practice Open
View article: The impact of inaccurate assumptions about antibody test accuracy on the parametrisation and results of infectious disease models of epidemics
The impact of inaccurate assumptions about antibody test accuracy on the parametrisation and results of infectious disease models of epidemics Open
The parametrisation of infectious disease models is often done based on epidemiological studies that use diagnostic and serology tests to establish disease prevalence or seroprevalence in the population being modelled. During outbreaks of …
View article: Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head/neck squamous cell carcinoma (HNSCC): A systematic review and network meta-analysis
Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head/neck squamous cell carcinoma (HNSCC): A systematic review and network meta-analysis Open
View article: Diagnostic test accuracy in longitudinal study settings: Theoretical approaches with use cases from clinical practice
Diagnostic test accuracy in longitudinal study settings: Theoretical approaches with use cases from clinical practice Open
In this study we evaluate how to estimate diagnostic test accuracy (DTA) correctly in the presence of longitudinal patient data (i.e., repeated test applications per patient). We used a nonparametric approach to estimate sensitivity and sp…
View article: Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season: the IMMUNEBRIDGE project
Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season: the IMMUNEBRIDGE project Open
Purpose Despite the need to generate valid and reliable estimates of protection levels against SARS-CoV-2 infection and severe course of COVID-19 for the German population in summer 2022, there was a lack of systematically collected popula…
View article: Immune correlates against SARS-CoV-2 infection – results of population and hospital-based studies in the IMMUNEBRIDGE project in Germany, 2022
Immune correlates against SARS-CoV-2 infection – results of population and hospital-based studies in the IMMUNEBRIDGE project in Germany, 2022 Open
Einleitung In spring 2022, Germany lacked systematically collected population-based SARS-CoV-2 data allowing real-time assessment of protection levels against severe course of COVID-19. To fill this gap, the IMMUNEBRIDGE project, a joint c…
View article: SARS-CoV-2 sero-immunity and quality of life in children and adolescents in relation to infections and vaccinations: the IMMUNEBRIDGE KIDS cross-sectional study, 2022
SARS-CoV-2 sero-immunity and quality of life in children and adolescents in relation to infections and vaccinations: the IMMUNEBRIDGE KIDS cross-sectional study, 2022 Open
View article: A unified framework towards diagnostic test development and evaluation during outbreaks of emerging infections
A unified framework towards diagnostic test development and evaluation during outbreaks of emerging infections Open
Background Diagnostic tests play a crucial role during an epidemic or a pandemic, both for individual patient care, and as a tool in population-level non-pharmaceutical interventions. The development and evaluation of such tests during epi…
View article: Effect of risk status for severe COVID-19 on individual contact behaviour during the SARS-CoV-2 pandemic in 2020/2021—an analysis based on the German COVIMOD study
Effect of risk status for severe COVID-19 on individual contact behaviour during the SARS-CoV-2 pandemic in 2020/2021—an analysis based on the German COVIMOD study Open
Background One of the primary aims of contact restriction measures during the SARS-CoV-2 pandemic has been to protect people at increased risk of severe disease from the virus. Knowledge about the uptake of contact restriction measures in …
View article: Diagnosing Acute Cellular Rejection after Paediatric Liver Transplantation—Is There Room for Interleukin Profiles?
Diagnosing Acute Cellular Rejection after Paediatric Liver Transplantation—Is There Room for Interleukin Profiles? Open
Background: The current gold standard to diagnose T-cell-mediated acute rejection (TCMR) requires liver histology. Using data from the ChilSFree study on immune response after paediatric liver transplantation (pLT), we aimed to assess whet…
View article: Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis
Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis Open
Background and purpose The role of the gut microbiome in the pathogenesis of Parkinson disease (PD) is under intense investigation, and the results presented are still very heterogeneous. These discrepancies arise not only from the highly …
View article: Dynamics of Contact Behaviour by Self-Reported Covid-19 Vaccination and Infection Status During the Covid-19 Pandemic in Germany—An Analysis of Two Large Population-Based Studies
Dynamics of Contact Behaviour by Self-Reported Covid-19 Vaccination and Infection Status During the Covid-19 Pandemic in Germany—An Analysis of Two Large Population-Based Studies Open
View article: The Impact of Inaccurate Assumptions About Diagnostic Test Accuracy on the Parametrisation and Results of Infectious Disease Models of Epidemics
The Impact of Inaccurate Assumptions About Diagnostic Test Accuracy on the Parametrisation and Results of Infectious Disease Models of Epidemics Open
View article: Changes in Social Contact Patterns in Germany During the Sars-Cov-2 Pandemic – an Analysis Based on the Covimod Study
Changes in Social Contact Patterns in Germany During the Sars-Cov-2 Pandemic – an Analysis Based on the Covimod Study Open
View article: 2. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorläufigen Ergebnissen an das Modellierungsnetz für schwere Infektionskrankheiten
2. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorläufigen Ergebnissen an das Modellierungsnetz für schwere Infektionskrankheiten Open
Diese zweite Interimsanalyse stellt eine Datenzusammenführung von Daten verschiedener Studien (GUIDE, NAKO Gesundheitsstudie, MuSPAD, STAAB, paedSAXCOVID, Wü-KITa-CoV, Corkid, IMMUNEBRIDGE_ED) dar, die im Sommer 2022 von Juni bis Anfang Se…
View article: 2. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorläufigen Ergebnissen an das Modellierungsnetz für schwere Infektionskrankheiten
2. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorläufigen Ergebnissen an das Modellierungsnetz für schwere Infektionskrankheiten Open
Diese zweite Interimsanalyse stellt eine Datenzusammenführung von Daten verschiedener Studien (GUIDE, NAKO Gesundheitsstudie, MuSPAD, STAAB, paedSAXCOVID, Wü-KITa-CoV, Corkid, IMMUNEBRIDGE_ED) dar, die im Sommer 2022 von Juni bis Anfang Se…
View article: Prediction models for SIRS, sepsis and associated organ dysfunctions in paediatric intensive care: study protocol for a diagnostic test accuracy study
Prediction models for SIRS, sepsis and associated organ dysfunctions in paediatric intensive care: study protocol for a diagnostic test accuracy study Open
Introduction Systemic inflammatory response syndrome (SIRS), sepsis and associated organ dysfunctions are life-threating conditions occurring at paediatric intensive care units (PICUs). Early recognition and treatment within the first hour…
View article: High-sensitivity troponin I with or without ultra-sensitive copeptin for the instant rule-out of acute myocardial infarction
High-sensitivity troponin I with or without ultra-sensitive copeptin for the instant rule-out of acute myocardial infarction Open
Background The instant, single-sampling rule-out of acute myocardial infarction (AMI) is still an unmet clinical need. We aimed at testing and comparing diagnostic performance and prognostic value of two different single-sampling biomarker…
View article: Major depressive disorders increase the susceptibility to self-reported infections in two German cohort studies
Major depressive disorders increase the susceptibility to self-reported infections in two German cohort studies Open
Introduction In several claims-based studies, major depressive disorder (MDD) has been associated with increased risk of hospitalization due to acute infections. It remains unclear if this is a causal effect, and if it generalizes to an in…
View article: A Method to Combine Neurofilament Light Measurements From Blood Serum and Plasma in Clinical and Population-Based Studies
A Method to Combine Neurofilament Light Measurements From Blood Serum and Plasma in Clinical and Population-Based Studies Open
Introduction Neurofilament light (NfL) can be detected in blood of healthy individuals and at elevated levels in those with different neurological diseases. We investigated if the choice of biological matrix can affect results when using N…
View article: Sexual Contact Patterns in High-Income Countries—A Comparative Analysis Using Data From Germany, the United Kingdom, and the United States
Sexual Contact Patterns in High-Income Countries—A Comparative Analysis Using Data From Germany, the United Kingdom, and the United States Open
Sexual contact patterns determine the spread of sexually transmitted infections and are a central input parameter for mathematical models in this field. We evaluated the importance of country-specific sexual contact pattern parametrization…