Nicole Santamauro
YOU?
Author Swipe
View article: A Translational Neuroscience & Computational Evaluation of a D1R Partial Agonist for Schizophrenia (TRANSCENDS): Rationale and Study Design of a Brain-Based Clinical Trial
A Translational Neuroscience & Computational Evaluation of a D1R Partial Agonist for Schizophrenia (TRANSCENDS): Rationale and Study Design of a Brain-Based Clinical Trial Open
Despite decades of research, cognitive impairment remains a critical untreated symptom for many patients with schizophrenia. One way to accelerate the development of pro-cognitive therapies for schizophrenia is to evaluate compounds using …
View article: Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures Open
Background: Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine’s molecul…
View article: Author response: Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Author response: Ketamine induces multiple individually distinct whole-brain functional connectivity signatures Open
Full text Figures and data Peer review Side by side Abstract Editor's evaluation eLife digest Introduction Materials and methods Results Discussion Data availability References Article and author information Metrics Abstract Background: Ke…
View article: Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures Open
Background Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine’s molecula…
View article: Illness Phase as a Key Assessment and Intervention Window for Psychosis
Illness Phase as a Key Assessment and Intervention Window for Psychosis Open
The phenotype of schizophrenia, regardless of etiology, represents the most studied psychotic disorder with respect to neurobiology and distinct phases of illness. The early phase of illness represents a unique opportunity to provide effec…
View article: Reward and loss incentives improve spatial working memory by shaping trial-by-trial posterior frontoparietal signals
Reward and loss incentives improve spatial working memory by shaping trial-by-trial posterior frontoparietal signals Open
View article: Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia
Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia Open
Decades of research have highlighted the importance of optimal stimulation of cortical dopaminergic receptors, particularly the D1R receptor (D1R), for prefrontal-mediated cognition. This mechanism is particularly relevant to the cognitive…
View article: Effects of reward on spatial working memory in schizophrenia.
Effects of reward on spatial working memory in schizophrenia. Open
Reward processing and cognition are disrupted in schizophrenia (SCZ), yet how these processes interface is unknown. In SCZ, deficits in reward representation may affect motivated, goal-directed behaviors. To test this, we examined the effe…
View article: Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition
Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition Open