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View article: Clinical Course and Outcomes of Cardiogenic Shock in COVID-19 : Insights from COVID-19 Critical Care Consortium
Clinical Course and Outcomes of Cardiogenic Shock in COVID-19 : Insights from COVID-19 Critical Care Consortium Open
Aim: Cardiogenic shock (CS) is a life-threatening condition observed in patients with severe heart diseases. Although COVID-19 is known to cause cardiac complications, the epidemiology and outcomes of CS in COVID-19 patients have not been …
View article: The impact of a multi-component hospital avoidance programme in residential aged care homes: a stepped-wedge cluster randomised trial
The impact of a multi-component hospital avoidance programme in residential aged care homes: a stepped-wedge cluster randomised trial Open
Objectives To investigate if a multi-component hospital avoidance intervention would reduce hospital bed days in residential aged care (RAC) homes. Design Prospective stepped-wedge cluster randomised trial with usual care and intervention …
View article: A cost-consequence analysis of a nudge intervention to improve hospital care of older people at the end of life: results from a stepped-wedge cluster randomised trial
A cost-consequence analysis of a nudge intervention to improve hospital care of older people at the end of life: results from a stepped-wedge cluster randomised trial Open
Objectives The ‘Intervention for Appropriate Care and Treatment’ (InterACT) was a nudge intervention to identify hospital patients at risk of imminent death or deterioration and communicate this information to treating clinical teams. The …
View article: Health Economic Analysis Plan for the Hospital Acquired Pneumonia PrEveNtion (HAPPEN) study: A multi-centre randomised control trial exploring the effectiveness of improving the frequency and quality of oral care in reducing the incidence of pneumonia
Health Economic Analysis Plan for the Hospital Acquired Pneumonia PrEveNtion (HAPPEN) study: A multi-centre randomised control trial exploring the effectiveness of improving the frequency and quality of oral care in reducing the incidence of pneumonia Open
The Hospital-acquired Pneumonia Prevention (HAPPEN) study is a multi-site, stepped wedge cluster randomised trial evaluating the impacts of improving oral care among adult patients to reduce the incidence of non-ventilator, hospital-acquir…
View article: A State-wide Retrospective Cohort Study Examining Effects of Transfusing Old Blood Products in Vascular Surgical Patients
A State-wide Retrospective Cohort Study Examining Effects of Transfusing Old Blood Products in Vascular Surgical Patients Open
Introduction We investigated the effects of transfusing blood products close to the expiration date (i.e., ≥35 days packed red blood cells (PRBCs) and >3 days platelets (PLTs)) on vascular patients. Methods We retrospectively examined all …
View article: Hospital Acquired Pneumonia Prevention (HAPPEN) Study: Statistical Analysis Plan
Hospital Acquired Pneumonia Prevention (HAPPEN) Study: Statistical Analysis Plan Open
The Hospital-acquired Pneumonia Prevention (HAPPEN) study is a multi-site trial evaluating the clinical effectiveness of improving oral care among adult patients to reduce the incidence of non-ventilator, hospital-acquired pneumonia (HAP).…
View article: Implementing an intervention to facilitate early detection of deterioration in aged care residents: Process evaluation of the EDDIE+ trial
Implementing an intervention to facilitate early detection of deterioration in aged care residents: Process evaluation of the EDDIE+ trial Open
Background: EDDIE + was a stepped wedge cluster randomised controlled trial with an embedded process evaluation in 11 residential aged care (RAC) homes in Queensland, Australia. The intervention aimed to upskill RAC staff to identify and m…
View article: A Validation Study of the Paediatric Non‐Urgent Risk Assessment Management and Nurse Escort Assessment (<scp>PaNURAMA</scp>) Tool for Paediatric Inter‐Hospital Transfers
A Validation Study of the Paediatric Non‐Urgent Risk Assessment Management and Nurse Escort Assessment (<span>PaNURAMA</span>) Tool for Paediatric Inter‐Hospital Transfers Open
Objective Decision support tools improve risk assessment in critical paediatric inter‐hospital transfers (IHT), however, data on non‐critical transfers of unwell children is limited. This study assessed the validity and reliability of a no…
View article: Economic Evaluation of Enhanced Cleaning and Disinfection of Shared Medical Equipment
Economic Evaluation of Enhanced Cleaning and Disinfection of Shared Medical Equipment Open
Importance The economic value of cleaning and disinfection of shared medical equipment is currently unknown. Objective To evaluate whether or not better environmental cleaning and disinfection of shared medical equipment would be cost-effe…
View article: Sports Metaresearch: An Emerging Discipline of Sport Science and Medicine
Sports Metaresearch: An Emerging Discipline of Sport Science and Medicine Open
View article: Sick of pie charts for your uni, school or work projects? Here are 5 other options
Sick of pie charts for your uni, school or work projects? Here are 5 other options Open
View article: Implementing Guidelines for hypothermia prevention with Local adaptation to keep periOperative patients Warm (GLOW): protocol of a stepped-wedge cluster randomised hybrid type II effectiveness-implementation study
Implementing Guidelines for hypothermia prevention with Local adaptation to keep periOperative patients Warm (GLOW): protocol of a stepped-wedge cluster randomised hybrid type II effectiveness-implementation study Open
Introduction Perioperative hypothermia is a common and preventable complication of surgery. Systems level change that enables perioperative teams to integrate hypothermia prevention into practice in ways that are contextually appropriate i…
View article: The varying perceptions of a statistician’s value, from “critical” to “not needed for 99.9% of applications”: A national study of human research ethics committees
The varying perceptions of a statistician’s value, from “critical” to “not needed for 99.9% of applications”: A national study of human research ethics committees Open
Currently, much health and medical research is wasted due to inappropriate study design oranalysis. Study designs could be improved using an expert review from a qualified statistician.The ethical review process is an ideal stage for this …
View article: An ovine septic shock model of live bacterial infusion
An ovine septic shock model of live bacterial infusion Open
View article: Neurological Complications and Outcomes in Critically Ill Patients With COVID-19: Results From International Neurological Study Group From the COVID-19 Critical Care Consortium
Neurological Complications and Outcomes in Critically Ill Patients With COVID-19: Results From International Neurological Study Group From the COVID-19 Critical Care Consortium Open
Background In this COVID-19 Critical Care Consortium (CCCC) sub-study, we qualified neurological complications associated with SARS-CoV2 infection. Methods The CCCC is an international, multicenter study. Eligible patients were COVID-19 pa…
View article: Patterns and Perceptions of Standard Order Set Use Among Physicians Working Within a Multihospital System: Mixed Methods Study
Patterns and Perceptions of Standard Order Set Use Among Physicians Working Within a Multihospital System: Mixed Methods Study Open
Background Electronic standard order sets automate the ordering of specific treatment, testing, and investigative protocols by physicians. These tools may help reduce unwarranted clinical variation and improve health care efficiency. Despi…
View article: Sex differences in the outcome of critically Ill patients with COVID-19 - An international multicenter critical care consortium study
Sex differences in the outcome of critically Ill patients with COVID-19 - An international multicenter critical care consortium study Open
View article: Clinician perspectives and recommendations regarding design of clinical prediction models for deteriorating patients in acute care
Clinician perspectives and recommendations regarding design of clinical prediction models for deteriorating patients in acute care Open
Background Successful deployment of clinical prediction models for clinical deterioration relates not only to predictive performance but to integration into the decision making process. Models may demonstrate good discrimination and calibr…
View article: Impact of Hemoglobin Levels on Composite Cardiac Arrest or Stroke Outcome in Patients With Respiratory Failure Due to COVID-19
Impact of Hemoglobin Levels on Composite Cardiac Arrest or Stroke Outcome in Patients With Respiratory Failure Due to COVID-19 Open
OBJECTIVES: Anemia has been associated with an increased risk of both cardiac arrest and stroke, frequent complications of COVID-19. The effect of hemoglobin level at ICU admission on a composite outcome of cardiac arrest or stroke in an i…
View article: Effects of red blood cell transfusion on patients undergoing cardiac surgery in Queensland – a retrospective cohort study
Effects of red blood cell transfusion on patients undergoing cardiac surgery in Queensland – a retrospective cohort study Open
View article: Worldwide application and valuation of extracorporeal membrane oxygenation support during the COVID-19 pandemic (WAVES)
Worldwide application and valuation of extracorporeal membrane oxygenation support during the COVID-19 pandemic (WAVES) Open
Objective The outcomes of COVID-19 patients on venovenous extracorporeal membrane oxygenation (VV-ECMO) varied. We aim to investigate the variability concerning location and timeframe. We conducted a retrospective analysis of data from 351…
View article: Prioritising deteriorating patients using time-to-event analysis: prediction model development and internal–external validation
Prioritising deteriorating patients using time-to-event analysis: prediction model development and internal–external validation Open
Background Binary classification models are frequently used to predict clinical deterioration, however they ignore information on the timing of events. An alternative is to apply time-to-event models, augmenting clinical workflows by ranki…
View article: Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries
Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries Open
View article: Planned but ever published? A retrospective analysis of clinical prediction model studies registered on clinicaltrials.gov since 2000
Planned but ever published? A retrospective analysis of clinical prediction model studies registered on clinicaltrials.gov since 2000 Open
Published clinical prediction model studies are only a fraction of overall research efforts, with many studies planned but not completed or published. Improving the uptake of study preregistration and follow-up will increase the visibility…
View article: The effect of an improved ICU physical environment on outcomes and post-ICU recovery—a protocol
The effect of an improved ICU physical environment on outcomes and post-ICU recovery—a protocol Open
View article: Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors
Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors Open
Background The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload‐independent …
View article: The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study
The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices: A Prospective Observational Pilot Study Open
Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to …
View article: Impact of a prospective feedback loop aimed at reducing non-beneficial treatments in older people admitted to hospital and potentially nearing the end of life. A cluster stepped-wedge randomised controlled trial
Impact of a prospective feedback loop aimed at reducing non-beneficial treatments in older people admitted to hospital and potentially nearing the end of life. A cluster stepped-wedge randomised controlled trial Open
Objectives To investigate if a prospective feedback loop that flags older patients at risk of death can reduce non-beneficial treatment at end of life. Design Prospective stepped-wedge cluster randomised trial with usual care and intervent…
View article: Oral care practices and hospital-acquired pneumonia prevention: A national survey of Australian nurses
Oral care practices and hospital-acquired pneumonia prevention: A national survey of Australian nurses Open
Findings from this survey will be used in conjunction with consumer feedback, to help inform a planned multi-centre randomised trial, the Hospital Acquired Pneumonia PrEveNtion (HAPPEN) study, aimed at reducing the incidence of HAP. Findin…
View article: Hemorrhage and thrombosis in COVID-19-patients supported with extracorporeal membrane oxygenation: an international study based on the COVID-19 critical care consortium
Hemorrhage and thrombosis in COVID-19-patients supported with extracorporeal membrane oxygenation: an international study based on the COVID-19 critical care consortium Open