Nelson C. Lau
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View article: DOT1L/menin inhibitors target replication fork plasticity and create novel vulnerability to PARP inhibitor in MLL-rearranged AML
DOT1L/menin inhibitors target replication fork plasticity and create novel vulnerability to PARP inhibitor in MLL-rearranged AML Open
Epigenetic deregulation is a major driver for acute myeloid leukemia (AML) including those with Mixed-Lineage Leukemia gene-rearrangement (MLLr). Over the past decades, significant efforts have been made by others and us to identify and ta…
View article: Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility
Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility Open
A quarter of the human population is infected with Mycobacterium tuberculosis , but less than 10% of those infected develop pulmonary TB. We developed a genetically defined sst1-susceptible mouse model that uniquely reproduces a defining f…
View article: Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility
Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility Open
A quarter of human population is infected with Mycobacterium tuberculosis, but less than 10% of those infected develop pulmonary TB. We developed a genetically defined sst1-susceptible mouse model that uniquely reproduces a defining featur…
View article: Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility
Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility Open
A quarter of human population is infected with Mycobacterium tuberculosis, but less than 10% of those infected develop pulmonary TB. We developed a genetically defined sst1-susceptible mouse model that uniquely reproduces a defining featur…
View article: The transcription factor Traffic jam orchestrates the somatic piRNA pathway in Drosophila ovaries
The transcription factor Traffic jam orchestrates the somatic piRNA pathway in Drosophila ovaries Open
The PIWI-interacting RNA (piRNA) pathway is essential for transposable element (TE) silencing in animal gonads. While the transcriptional regulation of piRNA pathway components in germ cells has been documented in mice and flies, their con…
View article: Somatic Miwi2 modulates mitochondrial function in airway multiciliated cells and exacerbates influenza pathogenesis
Somatic Miwi2 modulates mitochondrial function in airway multiciliated cells and exacerbates influenza pathogenesis Open
MIWI2, a P element-induced wimpy testes (PIWI) argonaute protein known for suppressing retrotransposons during male gonadogenesis, has an unexplored role in mammalian somatic cells. We identify MIWI2 multiciliated (M2MC) cells as a rare su…
View article: Transposable element small and long RNAs in aging brains and implications in Huntington’s and Parkinson’s disease
Transposable element small and long RNAs in aging brains and implications in Huntington’s and Parkinson’s disease Open
Transposable Elements (TEs) are implicated in aging and neurodegenerative disorders, but the impact of brain TE RNA dynamics on these phenomena is not fully understood. Therefore, we quantified TE RNA changes in aging post-mortem human and…
View article: Transposable Element (TE) insertion predictions from RNAseq inputs and TE impact on RNA splicing and gene expression in Drosophila brain transcriptomes
Transposable Element (TE) insertion predictions from RNAseq inputs and TE impact on RNA splicing and gene expression in Drosophila brain transcriptomes Open
Recent studies have suggested that Transposable Elements (TEs) residing in introns frequently splice into and alter primary gene-coding transcripts. To re-examine the exonization frequency of TEs into protein-coding gene transcripts, we re…
View article: The transcription factor Traffic jam orchestrates the somatic piRNA pathway in <i>Drosophila</i> ovaries
The transcription factor Traffic jam orchestrates the somatic piRNA pathway in <i>Drosophila</i> ovaries Open
The PIWI-interacting RNA (piRNA) pathway is essential for transposable element (TE) silencing in animal gonads. While the transcriptional regulation of piRNA pathway components in germ cells has been documented in mice and flies, their con…
View article: Traffic Jam activates the<i>Flamenco</i>piRNA cluster locus and the Piwi pathway to ensure transposon silencing and<i>Drosophila</i>fertility
Traffic Jam activates the<i>Flamenco</i>piRNA cluster locus and the Piwi pathway to ensure transposon silencing and<i>Drosophila</i>fertility Open
Flamenco (Flam) is the most prominent piRNA cluster locus expressed in Drosophila ovarian follicle cells, and it is required for female fertility to silence gypsy/mdg4 transposons. To determine how Flam is regulated, we used promoter-bashi…
View article: Transposable Element (TE) insertion predictions from RNAseq inputs and TE impact on RNA splicing and gene expression in<i>Drosophila</i>brain transcriptomes
Transposable Element (TE) insertion predictions from RNAseq inputs and TE impact on RNA splicing and gene expression in<i>Drosophila</i>brain transcriptomes Open
Recent studies have suggested that Transposable Elements (TEs) residing in introns frequently splice into and alter primary gene coding transcripts. To re-examine the exonization of TEs into protein-coding gene transcripts, we re-analyzed …
View article: Global genomics of<i>Aedes aegypti</i>unveils widespread and novel infectious viruses capable of triggering a small RNA response
Global genomics of<i>Aedes aegypti</i>unveils widespread and novel infectious viruses capable of triggering a small RNA response Open
The mosquito Aedes aegypti is a prominent vector for arboviruses, but the breadth of mosquito viruses that infects this specie is not fully understood. In the broadest global survey to date of over 200 Ae. aegypti small RNA samples, we det…
View article: Transposon and Transgene Tribulations in Mosquitoes: A Perspective of piRNA Proportions
Transposon and Transgene Tribulations in Mosquitoes: A Perspective of piRNA Proportions Open
Mosquitoes, like Drosophila, are dipterans, the order of “true flies” characterized by a single set of two wings. Drosophila are prime model organisms for biomedical research, while mosquito researchers struggle to establish robust molecul…
View article: Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility
Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility Open
A quarter of human population is infected with Mycobacterium tuberculosis, but less than 10% of those infected develop pulmonary TB. We developed a genetically defined sst1-susceptible mouse model that uniquely reproduces a defining featur…
View article: Transcriptomic and small RNA response to Mayaro virus infection in Anopheles stephensi mosquitoes
Transcriptomic and small RNA response to Mayaro virus infection in Anopheles stephensi mosquitoes Open
Mayaro virus (MAYV) is an arboviral pathogen in the genus Alphavirus that is circulating in South America with potential to spread to naïve regions. MAYV is also one of the few viruses with the ability to be transmitted by mosquitoes in th…
View article: Dengue Virus-2 Infection Affects Fecundity and Elicits Specific Transcriptional Changes in the Ovaries of Aedes aegypti Mosquitoes
Dengue Virus-2 Infection Affects Fecundity and Elicits Specific Transcriptional Changes in the Ovaries of Aedes aegypti Mosquitoes Open
Dengue fever (DF), caused by the dengue virus (DENV), is the most burdensome arboviral disease in the world, with an estimated 400 million infections each year. The Aedes aegypti mosquito is the main vector of DENV and transmits several ot…
View article: Transposable element landscapes in aging Drosophila
Transposable element landscapes in aging Drosophila Open
Genetic mechanisms that repress transposable elements (TEs) in young animals decline during aging, as reflected by increased TE expression in aged animals. Does increased TE expression during aging lead to more genomic TE copies in older a…
View article: Transposable element landscapes in aging Drosophila
Transposable element landscapes in aging Drosophila Open
Genetic mechanisms that repress transposable elements (TEs) in young animals decline during aging, as reflected by increased TE expression in aged animals. Does increased TE expression during aging lead to more genomic TE copies in older a…
View article: DNA templates with blocked long 3ʹ end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci
DNA templates with blocked long 3ʹ end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci Open
Knock-in of large transgenes by Cas9-mediated homology-directed repair (HDR) is an extremely inefficient process. Although the use of single-stranded oligonucleotides (ssODN) as an HDR donor has improved the integration of smaller transgen…
View article: Transposable element landscape changes are buffered by RNA silencing in aging<i>Drosophila</i>
Transposable element landscape changes are buffered by RNA silencing in aging<i>Drosophila</i> Open
Genetic mechanisms that repress transposable elements (TEs) in young animals decline during aging, as reflected by increased TE expression in aged animals. Does increased TE expression during aging lead to more genomic TE copies in older a…
View article: A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons
A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons Open
Although mosquitoes are major transmission vectors for pathogenic arboviruses, viral infection has little impact on mosquito health. This immunity is caused in part by mosquito RNA interference (RNAi) pathways that generate antiviral small…
View article: Diverse Defenses: A Perspective Comparing Dipteran Piwi-piRNA Pathways
Diverse Defenses: A Perspective Comparing Dipteran Piwi-piRNA Pathways Open
Animals face the dual threat of virus infections hijacking cellular function and transposons proliferating in germline genomes. For insects, the deeply conserved RNA interference (RNAi) pathways and other chromatin regulators provide an im…
View article: An integrated mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons
An integrated mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons Open
Although mosquitoes are major transmission vectors for pathogenic arboviruses, viral infection has little impact on mosquito health. This immunity is due in part to mosquito RNA interference (RNAi) pathways that generate antiviral small in…
View article: Har-P, a short P-element variant, weaponizes P-transposase to severely impair Drosophila development
Har-P, a short P-element variant, weaponizes P-transposase to severely impair Drosophila development Open
Without transposon-silencing Piwi-interacting RNAs (piRNAs), transposition causes an ovarian atrophy syndrome in Drosophila called gonadal dysgenesis (GD). Harwich (Har) strains with P-elements cause severe GD in F1 daughters when Har fath…