Nicolò Filippi
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View article: Dipeptidyl Peptidase 9 in Human Leukocytes: Novel Inhibitors Induce Caspase‐1‐ and Gasdermin‐Dependent Cell Death
Dipeptidyl Peptidase 9 in Human Leukocytes: Novel Inhibitors Induce Caspase‐1‐ and Gasdermin‐Dependent Cell Death Open
Dipeptidyl peptidase 9 (DPP9) is an intracellular serine protease with key roles in the immune response. In human leukocytes, DPP9 interacts with caspase recruitment domain‐containing protein 8 (CARD8) to form an inhibitory complex that pr…
View article: Druglike, <sup>18</sup>F-labeled PET Tracers Targeting Fibroblast Activation Protein
Druglike, <sup>18</sup>F-labeled PET Tracers Targeting Fibroblast Activation Protein Open
Fibroblast activation protein (FAP) is a very reliable biomarker for tissue remodeling. FAP has so far mainly been studied in oncology, but there is growing interest in the enzyme in other diseases like fibrosis. Recently, FAP-targeting di…
View article: Active site-directed probes targeting dipeptidyl peptidases 8 and 9
Active site-directed probes targeting dipeptidyl peptidases 8 and 9 Open
View article: Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin
Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin Open
Dipeptidyl peptidase 9 (DPP9) is a proline-selective serine protease that plays a key role in NLRP1- and CARD8-mediated inflammatory cell death (pyroptosis). No selective inhibitors have hitherto been reported for the enzyme: all published…
View article: Active Site-Directed Probes Targeting Dipeptidyl Peptidases 8 and 9
Active Site-Directed Probes Targeting Dipeptidyl Peptidases 8 and 9 Open