Nicolò Riggi
YOU?
Author Swipe
View article: KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma Open
Ewing sarcoma is a highly aggressive tumor arising in bones and soft tissues, driven by the fusion oncoprotein EWSR1::FLI1. This aberrant transcription factor binds to GGAA microsatellites, causing epigenetic reprogramming through the form…
View article: TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism
TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism Open
Tlx3, a master regulator of the fate specification of excitatory neurons, is primarily known to function in post-mitotic cells. Although we have previously identified TLX3 expression in the proliferating granule neuron progenitors (GNPs) o…
View article: EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors Open
EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-…
View article: Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma Open
The development of targeted therapies offers new hope for patients affected by incurable cancer. However, multiple challenges persist, notably in controlling tumor cell plasticity in patients with refractory and metastatic illness. Neurobl…
View article: CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas
CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas Open
CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue tumor that occurs most frequently in young adults. The key oncogenic driver of this disease is the expression of the CIC-DUX4 fusion protein as a result of chromosomal …
View article: Pre-clinical spheroid models identify BMX as a therapeutic target for metastatic MYCN non-amplified neuroblastoma
Pre-clinical spheroid models identify BMX as a therapeutic target for metastatic MYCN non-amplified neuroblastoma Open
The development of targeted therapies has provided new hope for an increasing number of cancer patients affected by previously incurable diseases. The clinical success of this approach, however, is limited by numerous challenges, including…
View article: Pre-clinical spheroid models identify BMX as a therapeutic target for metastatic MYCN non-amplified neuroblastoma
Pre-clinical spheroid models identify BMX as a therapeutic target for metastatic MYCN non-amplified neuroblastoma Open
The development of targeted therapies has provided new hope for an increasing number of cancer patients affected by previously incurable diseases. The clinical success of this approach, however, is limited by numerous challenges, including…
View article: DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins
DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins Open
Intrinsically disordered regions (IDRs) in DNA-associated proteins are known to influence gene regulation, but their distribution and cooperative functions in genome-wide regulatory programs remain poorly understood. Here we describe DisP-…
View article: Supplementary Table 6 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 6 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 6
View article: Supplementary Figure 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 4
View article: Supplementary Table 9 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 9 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 9
View article: Supplementary Figure 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 2
View article: Supplementary Figure 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 2
View article: Supplementary Table 9 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 9 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 9
View article: Supplementary Figure 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 5
View article: Data from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Data from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Cancer evolution determines molecular and morphologic intratumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma, disease progression and prognosis are associated with the appearance of morphological…
View article: Supplementary Figure 3 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 3 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 3
View article: Supplementary Table 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 2
View article: Supplementary Figure 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 1
View article: Data from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Data from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Cancer evolution determines molecular and morphologic intratumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma, disease progression and prognosis are associated with the appearance of morphological…
View article: Supplementary Figure 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 5
View article: Supplementary Table 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 4
View article: Supplementary Table 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 1
View article: Supplementary Table 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 1
View article: Supplementary Table 6 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 6 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 6
View article: Supplementary Figure 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 4
View article: Supplementary Figure 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 1
View article: Supplementary Table 7 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 7 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 7
View article: Supplementary Table 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 5