Karsten Niehaus
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View article: Genomic and proteomic characterization of a newly isolated <i>Paenarthrobacter ilicis</i> strain and its plasmid-mediated xanthan degradation
Genomic and proteomic characterization of a newly isolated <i>Paenarthrobacter ilicis</i> strain and its plasmid-mediated xanthan degradation Open
Environmental soil samples enriched with xanthan gum led to the discovery and isolation of a novel strain of motile Paenarthrobacter ilicis in Bielefeld, Germany, which possesses a previously uncharacterized xanthan utilization gene region…
View article: Use of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to visualize and support interpretation of toxic effects of 4-hydroxyphenylpyruvate dioxygenase inhibitors in rat tissues
Use of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to visualize and support interpretation of toxic effects of 4-hydroxyphenylpyruvate dioxygenase inhibitors in rat tissues Open
4-Hydroxyphenylpyruvate dioxygenase inhibitors (HPPDi) are mainly used as herbicides and for therapeutic use in genetic diseases of tyrosine catabolism. Their primary mechanism of action is the inhibition of the second enzyme of tyrosine c…
View article: Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5
Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5 Open
Introduction Concerns about ecological degradation and reduced biodiversity have intensified the search for sustainable solutions in agriculture. The use of plant growth-promoting bacteria (PGPB) offers a promising alternative to enhance s…
View article: Time resolved cell painting enables rapid assessment of cell phenotypes
Time resolved cell painting enables rapid assessment of cell phenotypes Open
Cell Painting is an advanced imaging technique for drug discovery used to study cellular phenotypes by simultaneously labeling various organelles/structures and analyzing the resulting multidimensional phenotypic features through a sophist…
View article: Evaluation of 3D-Printed Microfluidic Structures for Use in AML-Specific Biomarker Detection of PML::RARA
Evaluation of 3D-Printed Microfluidic Structures for Use in AML-Specific Biomarker Detection of PML::RARA Open
An obstacle for many microfluidic developments is the fabrication of its structures, which is often complex, time-consuming, and expensive. Additive manufacturing can help to reduce these barriers. This study investigated whether the resul…
View article: Study of excess manganese stress response highlights the central role of manganese exporter Mnx for holding manganese homeostasis in the cyanobacterium Synechocystis sp. PCC 6803
Study of excess manganese stress response highlights the central role of manganese exporter Mnx for holding manganese homeostasis in the cyanobacterium Synechocystis sp. PCC 6803 Open
Cellular levels of the essential micronutrient manganese (Mn) need to be carefully balanced within narrow borders. In cyanobacteria, a sufficient Mn supply is critical for ensuring the function of the oxygen-evolving complex as the central…
View article: Mucosa-like differentiation of head and neck cancer cells is inducible and drives the epigenetic loss of cell malignancy
Mucosa-like differentiation of head and neck cancer cells is inducible and drives the epigenetic loss of cell malignancy Open
Head and neck squamous cell carcinoma (HNSCC) is a highly malignant disease with high death rates that have remained substantially unaltered for decades. Therefore, new treatment approaches are urgently needed. Human papillomavirus-negativ…
View article: Differential gene expression in leaves and roots of Hydrangea serrata treated with aluminium chloride
Differential gene expression in leaves and roots of Hydrangea serrata treated with aluminium chloride Open
Hydrangea serrata , also knowen as the Japanese tea hortensia, is known for its sweet taste and health properties of bevarages produced from this plant. The H. serrata 3,4-dihydroisocoumarins, hydrangenol and phyllodulcin harbour a variety…
View article: Study of excess manganese stress response highlights the central role of manganese exporter Mnx for holding manganese homeostasis in the cyanobacterium<i>Synechocystis sp.</i>PCC 6803
Study of excess manganese stress response highlights the central role of manganese exporter Mnx for holding manganese homeostasis in the cyanobacterium<i>Synechocystis sp.</i>PCC 6803 Open
Cellular levels of the essential micronutrient manganese (Mn) need to be carefully balanced within narrow boarders. In cyanobacteria, sufficient Mn supply is critical for assuring the function of the oxygen-evolving complex as central part…
View article: Sigma Factor Engineering in Actinoplanes sp. SE50/110: Expression of the Alternative Sigma Factor Gene ACSP50_0507 (σHAs) Enhances Acarbose Yield and Alters Cell Morphology
Sigma Factor Engineering in Actinoplanes sp. SE50/110: Expression of the Alternative Sigma Factor Gene ACSP50_0507 (σHAs) Enhances Acarbose Yield and Alters Cell Morphology Open
Sigma factors are transcriptional regulators that are part of complex regulatory networks for major cellular processes, as well as for growth phase-dependent regulation and stress response. Actinoplanes sp. SE50/110 is the natural producer…
View article: Comprehensive Proteome Profiling of a Xanthomonas campestris pv. Campestris B100 Culture Grown in Minimal Medium with a Specific Focus on Nutrient Consumption and Xanthan Biosynthesis
Comprehensive Proteome Profiling of a Xanthomonas campestris pv. Campestris B100 Culture Grown in Minimal Medium with a Specific Focus on Nutrient Consumption and Xanthan Biosynthesis Open
Xanthan, a bacterial polysaccharide, is widespread in industrial applications, particularly as a food additive. However, little is known about the process of xanthan synthesis on the proteome level, even though Xanthomonas campestris is fr…
View article: Inducible mucosa-like differentiation of head and neck cancer cells drives the epigenetically determined loss of cell malignancy
Inducible mucosa-like differentiation of head and neck cancer cells drives the epigenetically determined loss of cell malignancy Open
Background Human papillomavirus-negative head and neck squamous cell carcinoma (HNSCC) is a highly malignant disease with high death rates that have remained substantially unaltered for decades. Therefore, new treatment approaches are urge…
View article: Corrigendum: Development of a polyphagous leaf beetle on different host plant species and its detoxification of glucosinolates
Corrigendum: Development of a polyphagous leaf beetle on different host plant species and its detoxification of glucosinolates Open
Friedrichs J, Schweiger R, Geisler S, et al. Corrigendum: Development of a polyphagous leaf beetle on different host plant species and its detoxification of glucosinolates (vol 10, 960850, 2022). Frontiers in Ecology and Evolution . 2023;…
View article: Genome-Based Analysis of Virulence Factors and Biofilm Formation in Novel P. aeruginosa Strains Isolated from Household Appliances
Genome-Based Analysis of Virulence Factors and Biofilm Formation in Novel P. aeruginosa Strains Isolated from Household Appliances Open
In household washing machines, opportunistic pathogens such as Pseudomonas aeruginosa are present, which represent the household as a possible reservoir for clinical pathogens. Here, four novel P. aeruginosa strains, isolated from differen…
View article: RcgA and RcgR, Two Novel Proteins Involved in the Conjugative Transfer of Rhizobial Plasmids
RcgA and RcgR, Two Novel Proteins Involved in the Conjugative Transfer of Rhizobial Plasmids Open
Extrachromosomal DNA elements, such as plasmids, allow for the adaptation of bacteria to new environments by conferring new determinants. Via conjugation, plasmids can be transferred between members of the same bacterial species, different…
View article: Supplementary material for "RcgA and RcgR, two novel proteins involved in conjugative transfer of rhizobial plasmids"
Supplementary material for "RcgA and RcgR, two novel proteins involved in conjugative transfer of rhizobial plasmids" Open
Rhizobia are gram-negative bacteria able to establish a nitrogen-fixing symbiotic interaction with leguminous plants. Rhizobia usually harbor several plasmids in their genome which can be transferred to other organisms by conjugation. Two …
View article: Development of a polyphagous leaf beetle on different host plant species and its detoxification of glucosinolates
Development of a polyphagous leaf beetle on different host plant species and its detoxification of glucosinolates Open
Herbivores face a broad range of defences when feeding on plants. By mixing diets, polyphagous herbivores are assumed to benefit during their development by gaining a better nutritional balance and reducing the intake of toxic compounds fr…
View article: Impact of left atrial appendage fibrosis on atrial fibrillation in patients following coronary bypass surgery
Impact of left atrial appendage fibrosis on atrial fibrillation in patients following coronary bypass surgery Open
Objectives We aimed to assess the relationship of left atrial appendage (LAA) fibrosis with atrial fibrillation (AF) and postoperative events in patients receiving coronary artery bypass graft surgery (CABG). Background Increased atrial fi…
View article: Two Flagellar mutants of Xanthomonas campestris are characterized by enhanced xanthan production and higher xanthan viscosity
Two Flagellar mutants of Xanthomonas campestris are characterized by enhanced xanthan production and higher xanthan viscosity Open
Xanthomonas campestris strains are used world-wide for the production of the industrially important exopolysaccharide xanthan. The high industrial relevance of xanthan can be explained by its extraordinary qualities as rheological control …
View article: Analysis of Gum proteins involved in xanthan biosynthesis throughout multiple cell fractions in a “single-tube”
Analysis of Gum proteins involved in xanthan biosynthesis throughout multiple cell fractions in a “single-tube” Open
Xanthomonas is a phytopathogenic bacterium and of industrial interest due to its capability to produce xanthan, used as a thickener and emulsifier in the food and non-food industry. Until now, proteome analyses of Xcc lacking a detailed vi…
View article: Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort
Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort Open
The detection of strains from the middle east, supports the assumption that strains co-travel with the refugees and persist despite a transition of the host's living conditions. Whole genome data analysis does not permit to finally evaluat…
View article: Plant Transcriptome Reprograming and Bacterial Extracellular Metabolites Underlying Tomato Drought Resistance Triggered by a Beneficial Soil Bacteria
Plant Transcriptome Reprograming and Bacterial Extracellular Metabolites Underlying Tomato Drought Resistance Triggered by a Beneficial Soil Bacteria Open
Water deficit is one of the major constraints to crop production and food security worldwide. Some plant growth-promoting rhizobacteria (PGPR) strains are capable of increasing plant drought resistance. Knowledge about the mechanisms under…
View article: A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer
A new technological approach in diagnostic pathology: mass spectrometry imaging-based metabolomics for biomarker detection in urachal cancer Open
Urachal adenocarcinomas (UrC) are rare but aggressive. Despite being of profound therapeutic relevance, UrC cannot be differentiated by histomorphology alone from other adenocarcinomas of differential diagnostic importance. As no reliable …