Niek Brosens
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View article: M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue
M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue Open
View article: Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism
Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism Open
INTRODUCTION Early‐life stress (ES) increases the risk for Alzheimer's disease (AD). We and others have shown that ES aggravates amyloid‐beta (Aβ) pathology and promotes cognitive dysfunction in APP/PS1 mice, but underlying mechanisms rema…
View article: Shaping Memories via Stress: A Synaptic Engram Perspective
Shaping Memories via Stress: A Synaptic Engram Perspective Open
View article: Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice
Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice Open
Background: Exposure to stress early in life increases the susceptibility to Alzheimer’s disease (AD) pathology in aged AD mouse models. So far, the underlying mechanisms have remained elusive. Objective: To investigate 1) effects of early…
View article: Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity
Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity Open
Glucocorticoids are potent memory modulators that can modify behavior in an adaptive or maladaptive manner. Elevated glucocorticoid levels after learning promote memory consolidation at recent time points, but their effects on remote time …
View article: Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteins
Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteins Open
Epidemiological evidence indicates that early life stress (ES) exposure increases the risk for later-life diseases, such as Alzheimer’s disease (AD). Accordingly, we and others have shown that ES aggravates the development of, and response…
View article: Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population
Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population Open