Niels H. Secher
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View article: The effect of respiratory metaboreflex on cerebral haemodynamics during exercise
The effect of respiratory metaboreflex on cerebral haemodynamics during exercise Open
View article: Modulation of the human brain oxygen extraction fraction and metabolic rate in response to hyperoxia: the role of hypocapnia
Modulation of the human brain oxygen extraction fraction and metabolic rate in response to hyperoxia: the role of hypocapnia Open
Hyperoxia exposure reduces cerebral blood flow (CBF) and oxygen delivery (CDo 2 ). Hyperoxia also provokes hyperventilation, which leads to hypocapnia. Although hypocapnia may amplify hyperoxia-induced reductions in CBF and CDo 2 , its eff…
View article: Hemodynamics and Drinking in the Giraffe
Hemodynamics and Drinking in the Giraffe Open
Background The circulation of 4–6 m tall giraffes is markedly affected by gravity. To ensure cerebral perfusion, upright giraffes generate a blood pressure in excess of 200 mmHg. Before drinking, the head is lowered by 3–5 m, providing exc…
View article: The Impact of Weight-bearing Exercise, Non–Weight-bearing Exercise, and Cardiovascular Stress on Biochemical Markers of Cartilage Turnover in Patients With Mild to Moderate Knee Osteoarthritis – A Sequential, Cross-Over, Clinical Study
The Impact of Weight-bearing Exercise, Non–Weight-bearing Exercise, and Cardiovascular Stress on Biochemical Markers of Cartilage Turnover in Patients With Mild to Moderate Knee Osteoarthritis – A Sequential, Cross-Over, Clinical Study Open
Objective To investigate how running, cycling, and sedentary cardiovascular stress impact biomarkers of cartilage turnover acutely in subjects with knee osteoarthritis (OA). Design This was a sequential, cross-over, clinical study. Forty s…
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View article: Circulating Plasma Oxytocin Level Is Elevated by High-Intensity Interval Exercise in Men
Circulating Plasma Oxytocin Level Is Elevated by High-Intensity Interval Exercise in Men Open
Purpose We evaluated whether repeated high-intensity interval exercise (HIIE) influences plasma oxytocin (OT) concentration in healthy men, and, given that OT is mainly synthesized in the hypothalamus, we assessed the concentration differe…
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View article: Attenuated pulsatile transition to the cerebral vasculature during high‐intensity interval exercise in young healthy men
Attenuated pulsatile transition to the cerebral vasculature during high‐intensity interval exercise in young healthy men Open
High‐intensity interval exercise (HIIE) is recommended because it provides favourable haemodynamic stimulation, but excessive haemodynamic fluctuations may be an adverse impact on the brain. We tested whether the cerebral vasculature is pr…
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View article: Impact of polymorphism in the β2-receptor gene on the metabolic response to epinephrine after repeated hypoglycemia
Impact of polymorphism in the β2-receptor gene on the metabolic response to epinephrine after repeated hypoglycemia Open
The β2-receptor mediates the metabolic response to epinephrine. This study investigates the impact of the β2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypogl…
View article: Impact of Polymorphism in the β2-Receptor Gene on the Metabolic Response to Epinephrine After Repeated Hypoglycemia
Impact of Polymorphism in the β2-Receptor Gene on the Metabolic Response to Epinephrine After Repeated Hypoglycemia Open
The β2-receptor mediates the metabolic response to epinephrine. This study investigates the impact of the β2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Twe…
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View article: The effect of a mesenteric traction syndrome on internal carotid artery blood flow
The effect of a mesenteric traction syndrome on internal carotid artery blood flow Open
Purpose During abdominal surgery, manipulation of internal organs may induce a “mesenteric traction syndrome” (MTS) including a triad of flushing, hypotension, and tachycardia that lasts for approximately 30 min. We evaluated whether MTS a…
View article: Endothelial Cell Phenotypes Demonstrate Different Metabolic Patterns and Predict Mortality in Trauma Patients
Endothelial Cell Phenotypes Demonstrate Different Metabolic Patterns and Predict Mortality in Trauma Patients Open
In trauma patients, shock-induced endotheliopathy (SHINE) is associated with a poor prognosis. We have previously identified four metabolic phenotypes in a small cohort of trauma patients (N = 20) and displayed the intracellular metabolic …
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View article: GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans
GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans Open
Objective Growth differentiation factor (GDF)-15 is implicated in regulation of metabolism and circulating GDF15 increases in response to exercise. The source and regulation of the exercise-induced increase in GDF15 is, however not known. …
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View article: Mid‐regional plasma pro‐atrial natriuretic peptide and stroke volume responsiveness for detecting deviations in central blood volume following major abdominal surgery
Mid‐regional plasma pro‐atrial natriuretic peptide and stroke volume responsiveness for detecting deviations in central blood volume following major abdominal surgery Open
Background A reduced central blood volume is reflected by a decrease in mid‐regional plasma pro‐atrial natriuretic peptide (MR‐proANP), a stable precursor of ANP, and a volume deficit may also be assessed by the stroke volume (SV) response…
View article: Effect of adrenaline on serum mid‐regional pro‐atrial natriuretic peptide and central blood volume
Effect of adrenaline on serum mid‐regional pro‐atrial natriuretic peptide and central blood volume Open
New Findings What is the central question in this study? Atrial natriuretic peptide (ANP) is secreted in response to atrial wall distension and thus allows for evaluation, albeit indirect, of the central blood volume. Adrenaline has chrono…
View article: An Estimate of Plasma Volume Changes Following Moderate-High Intensity Running and Cycling Exercise and Adrenaline Infusion
An Estimate of Plasma Volume Changes Following Moderate-High Intensity Running and Cycling Exercise and Adrenaline Infusion Open
Introduction: Plasma volume (PV) changes in response to physical activity, possibly as a consequence of adrenergic activation. We estimated changes in PV in response to common exercise modalities; cycling and running as well as adrenaline …
View article: To identify normovolemia in humans: The stroke volume response to passive leg raising vs. head‐down tilt
To identify normovolemia in humans: The stroke volume response to passive leg raising vs. head‐down tilt Open
Volume responsiveness can be evaluated by tilting maneuvers such as head‐down tilt (HDT) and passive leg raising (PLR), but the two procedures use different references (HDT the supine position; PLR the semi‐recumbent position). We tested w…
View article: AB0984 CHANGES IN PLASMA VOLUME WHEN MEASURING BIOCHEMICAL MARKERS OF JOINT TISSUE TURNOVER IN RELATION TO ACUTE PHYSICAL ACTIVITY
AB0984 CHANGES IN PLASMA VOLUME WHEN MEASURING BIOCHEMICAL MARKERS OF JOINT TISSUE TURNOVER IN RELATION TO ACUTE PHYSICAL ACTIVITY Open
View article: Evaluation of Neurologic and Psychiatric Outcomes After Hospital Discharge Among Adult Survivors of Cardiac Arrest
Evaluation of Neurologic and Psychiatric Outcomes After Hospital Discharge Among Adult Survivors of Cardiac Arrest Open
In this cohort study, patients discharged after cardiac arrest had an increased rate of subsequent stroke, epilepsy, dementia, depression, and anxiety compared with patients with myocardial infarction and people from the general population…
View article: Editorial: Advances in Rowing Physiology
Editorial: Advances in Rowing Physiology Open
Almost 100 years ago, it was considered that “the rowing of a crew in a racing shell with sliding seats is a form of exercise in which a greater total energy expenditure is attainable, for periods of five to 20 min, than under any other co…
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View article: Impact of Polymorphism in the β2-Receptor Gene on Metabolic Responses to Repeated Hypoglycemia in Healthy Humans
Impact of Polymorphism in the β2-Receptor Gene on Metabolic Responses to Repeated Hypoglycemia in Healthy Humans Open
Context The Arg16 variant in the β2-receptor gene is associated with increased risk of severe hypoglycemia in subjects with type 1 diabetes mellitus. Objective We hypothesized that the Arg16 variant is associated with decreased metabolic a…
View article: Dose of Bicarbonate to Maintain Plasma pH During Maximal Ergometer Rowing and Consequence for Plasma Volume
Dose of Bicarbonate to Maintain Plasma pH During Maximal Ergometer Rowing and Consequence for Plasma Volume Open
Rowing performance may be enhanced by attenuated metabolic acidosis following bicarbonate (BIC) supplementation. This study evaluated the dose of BIC needed to eliminate the decrease in plasma pH during maximal ergometer rowing and assesse…